Abstract: Objective To analyze the epidemic trends in malignant tumor incidence rates from 2011 to 2014 in Chizhou, Maanshan and Tongling areas of Anhui province. Methods Data from cancer registry system of Anhui and Medical reimbursement system were encoded according to ICD-10 classification. Crude rate, age standardized rate (ASR) and constituent rate were calculated by sex, age group and year. Results From 2011 to 2014, the annual crude incidence of malignant tumor was 243.88/100 000 per (male 299.85/100 000, female 185.94/100 000) and ASR was 170.81/100 000 (male 201.41/100 000, female 135.82/100 000). The incidence of cancer peaked among residents aged 80-years and declined sharply after 90 years old. The top three malignant tumor were gastric cancer, lung cancer and esophageal cancer. During the four years, cancer spectrum showed slight change with lower incidence of cerebral, nasopharyngeal cancer and higher incidence of bladder, thyroid cancer. Conclusions The incidence of malignant cancer in areas along the Yangtze River of Anhui Province presented upward trend. Digestive system cancers were still the major causes which threatened people's life and health. Targeted strategies should be taken to improve current situation.