Abstract: Objective To explore the relationship between diurnal temperature range (DTR) and daily admission number of schizophrenia. Methods The data of daily admission of schizophrenia and meteorological and pollutant data in the same period of 2014-2016 in Tongling City were collected. The poisson generalized linear regression and the distributed lag nonlinear model (DLNM) were used in combination to control the relative humidity, pollutants, seasonal and long-term trends and other factors, analysis of DTR on schizophrenia daily admission. Results When the DTR reached 10.2℃ (P₇₅), the number of admissions to schizophrenia increased (RR=1.058, 95% CI:1.030-1.088,P=0.026), and the risk increased continuously with the increase of DTR the day of exposure appears and would last until the 15th day. Results of gender, age and occupational stratification showed that males and those aged 20-39 were more susceptible to DTR. At larger DTR, farmers were at higher risk of admission than other occupational groups. Conclusions A large DTR can increase the admission of schizophrenia, and there is a lag of 0-15 days. Therefore, it is of great significance to take appropriate interventions to control the risk brought by the temperature drop when the DTR is large.