Abstract: Objective To analyze the correlation between the degree of internet dependence and the state of mental health of medical college students. Methods The internet dependence of college students was investigated by internet addiction scale, and the mental health of college students was investigated by symptom checklist 90 (SCL-90). The differences between different groups of college students' internet dependence and mental health state were analyzed. And the relationship between internet dependence and mental health was studied. Results The internet addiction rate of college students reached 16.72%. There were differences in the degree of internet dependence among different genders, and the differences of abstinence among the factors were statistically significant (χ²=4.487,P=0.034). There were significant differences in tolerance, abstinence and time management among the internet dependence factors of different grades (all P<0.05). There were significant differences in mental health status among different genders and grades of college students (all P<0.05).There was a positive multiple linear regression relationship between compulsive, salience and interpersonal health academic of internet dependence factors and SCL-90 score (all P<0.05). Conclusions There is a correlation between internet dependence and mental health, and internet addiction may aggravate the mental health of college students.