河北省2008-2017年手足口病流行和病原特征分析

朱宝增; 赵文娜; 刘莹莹; 于秋丽; 苏通; 谢赟; 李琦

doi:10.16462/j.cnki.zhjbkz.2019.03.023

河北省2008-2017年手足口病流行和病原特征分析

doi: 10.16462/j.cnki.zhjbkz.2019.03.023

1.
063000 唐山, 华北理工大学公共卫生学院
2.
050021 石家庄, 河北省疾病预防控制中心病毒病防治所

基金项目:

“十三五”国家科技重大专项课题 2018ZX1071300

河北省科技计划项目 172777111D

详细信息

通讯作者:
李琦, E-mail: liqinew@aliyun.com

中图分类号: R181.2
计量
- 文章访问数: 324
- HTML全文浏览量: 127
- PDF下载量: 28
- 被引次数: 0
出版历程
- 收稿日期: 2018-10-08
- 修回日期: 2018-12-26
- 刊出日期: 2019-03-10

Epidemiologic characteristics and pathogen surveillance of hand, foot and mouth disease in Hebei province from 2008 to 2017

1.
Public Health School, North China University of Science and Technology, Tangshan 063000, China
2.
Hebei provincial Center for Disease Control and Prevention, Shijiazhuang 050021, China

摘要

摘要: 目的分析2008-2017年河北省手足口病（hand-foot-mouth disease，HFMD）的流行病学及病原特征，为HFMD的防控提供科学依据。方法收集2008-2017年HFMD疫情资料和实验室检测结果，进行描述流行病学分析。结果 2008-2017年河北省累计报告HFMD病例690 368例，重症4 939例，死亡208例，年均发病率为95.53/10万。2009年，轻型病例报告病例数最多，而重症和死亡则是2010年。报告发病人数呈隔年增加但总体减少的趋势。2008年、2009年和2012年4~6月份间形成春夏季发病主高峰，2010年、2011年和2013-2017年5~7月份出现春夏主高峰，主峰值落在的月份呈向后延迟趋势。男女的性别比是1.59：1，死亡病例以散居儿童和幼托儿童为主。其它肠道病毒、肠道病毒71型（human enterovirus 71，EV-A71）和柯萨奇病毒A组16型（coxasckievirus A16，CV-A16）交替成为普通病例的主要病原，不同病例类型的病原构成不同且差异有统计学意义（χ²=2 274.17，P<0.001）。结论报告死亡和重症病例数呈大幅减少趋势，应适时调整防控重点，提高对HFMD轻型病例的重视，进一步加强对其他肠道病原谱的监测。
- 手足口病 /
- 流行病学特征 /
- 病原学 /
- 其它肠道病毒
Abstract: Objective To analyze the epidemiological and pathogenic characteristics of hand-foot-mouth disease (HFMD) in Hebei Province from 2008 to 2017, so as to provide scientific evidence for prevention and control of HFMD. Methods The epidemic data and laboratory detection data of HFMD from 2008 to 2017 were collected and analyzed by descriptive epidemiology. Results From 2008 to 2017, a total of 690 368 cases of hand, foot and mouth disease, including 4 939 severe cases and 208 deaths were reported in Hebei Province, with an average annual incidence of 95.53/100 000. The largest number of reported light cases were 2009, while severe cases and deaths were in 2010. The number of reported cases increased every other year but decreased in general. In 2008, 2009 and 2012, the main peak of the onset of spring and summer was formed from April to June. In 2010, 2011 and 2013-2017, the main peak of the onset of spring and summer was from May to July. Main peak value in spring and summer showed a backward delayed trend. The sex ratio between men and women was 1.59:1.The majority of deaths case were scattered children and preschool case. Other enteroviruses, human enterovirus 71, (EV-A71) and coxasckievirus A16, (CV-A16) alternately became the main pathogens of common cases. The pathogenic composition of different cases was different and the difference was statistically significant (χ²=2274.17, P<0.001). Conclusion The number of reported deaths and severe cases has decreased significantly. It is necessary to adjust the focus of prevention and control, pay more attention to the mild cases of FHMD, and further strengthen the monitoring of other enteroviruses pathogenic spectrum.
- Hand, foot and mouth disease /
- Epidemiologic characteristics /
- Pathogen /
- other enteroviruses

HTML全文

图 1 2008-2017年河北省HFMD发病病例、重症病例及死亡病例年分布

Figure 1. HFMD cases, severe cases and death cases by year in Hebei from 2008 to 2017

下载: 全尺寸图片幻灯片

图 2 2008-2017年河北省HFMD发病病例、重症病例及死亡病例月分布

Figure 2. HFMD cases, severe cases and death cases by month in Hebei from 2008 to 2017

下载: 全尺寸图片幻灯片

图 3 2008-2017年河北省HFMD不同病例类型病原构成情况

Figure 3. Pathogenic spectrum of HFMD in Hebei from 2008 to 2017

下载: 全尺寸图片幻灯片

表 1 2008-2017年河北省HFMD发病、重症及死亡情况

Table 1. HFMD cases severe cases and death cases in Hebei, 2008-2017

年份	病例数(人)	发病率(1/10万)	重症病例数(人)	重症率(1/100)	死亡病例数(人)	死亡率(1/10万)	病死率(1/100)
2008	29 563	42.58	135	0.46	14	0.02	0.05
2009	110 148	157.61	931	0.85	28	0.04	0.03
2010	95 830	136.23	1 732	1.81	84	0.12	0.09
2011	71 864	100.03	550	0.77	19	0.03	0.03
2012	82 690	114.23	756	0.91	15	0.02	0.02
2013	56 737	77.98	215	0.38	24	0.03	0.04
2014	85 271	116.30	332	0.39	15	0.02	0.02
2015	52 422	71.00	58	0.11	0	0.00	0.00
2016	60 753	81.84	160	0.26	5	0.01	0.01
2017	45 090	60.40	70	0.16	4	0.01	0.01
合计	690 368	95.53	4 939	0.72	208	0.03	0.03

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