2004-2016年中国女性生殖系统恶性肿瘤死亡趋势分析

魏长慧; 朱继存; 牛媛娜; 王璐; 贺君剑; 马婧; 孙长青

doi:10.16462/j.cnki.zhjbkz.2019.05.003

2004-2016年中国女性生殖系统恶性肿瘤死亡趋势分析

doi: 10.16462/j.cnki.zhjbkz.2019.05.003

1.
450001 郑州, 郑州大学公共卫生学院社会医学与卫生事业管理教研室
2.
450000 郑州, 郑州大学第二附属医院质量控制办公室
3.
450000 郑州, 郑州大学附属郑州中心医院门诊办公室
4.
450001 郑州, 郑州大学教育学院教育系

基金项目:

河南省科技攻关重点项目 192102310191

河南省高等学校重点科研项目 19A330005

详细信息

通讯作者:
孙长青, E-mail: suncq@zzu.edu.cn

中图分类号: R737.33
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出版历程
- 收稿日期: 2018-11-17
- 修回日期: 2019-03-01
- 刊出日期: 2019-05-10

Analysis of the mortality trend of female reproductive system cancer in China from 2004 to 2016

1.
Department of Social Medicine and Health Service Management, College of Public Health, Zhengzhou University, Zhengzhou 450001, China
2.
Quality Control Office, Second Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, China
3.
Outpatient Office, Affiliated Central Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, China
4.
Department of Education, College of Education, Zhengzhou University, Zhengzhou 450001, China

Funds:

Key Scientific and Technological Project of Henan Province 192102310191

Key Scientific Research Projects of Institutions of Higher Education in Henan Province 19A330005

More Information

Corresponding author: SUN Chang-qing, E-mail: suncq@zzu.edu.cn

摘要

摘要: 目的研究分析2004-2016年中国女性生殖系统恶性肿瘤的死亡率水平及其变化趋势，为癌症预防和控制措施的制定与实施提供科学依据。方法从全国疾病监测系统死因监测数据中选取宫颈癌、宫体癌、卵巢癌的死亡数据，分别计算不同时间的粗死亡率与标化死亡率，采用Joinpoint软件分析年度变化趋势。结果 2004-2016年，中国女性宫颈癌死亡率明显增加，2011年之后死亡趋势明显加快(annual percent change，APC=13.7%)，且中国女性宫颈癌死亡率农村高于城市(P < 0.05)；宫体癌死亡率相对稳定，2013年之后呈现出下降趋势(APC=-23.5%)；卵巢癌死亡率有所增加，但其死亡趋势无统计学意义。结论 2004-2016年，中国女性宫体癌死亡情况有所好转，宫颈癌死亡情况仍较为严重，且存在城乡差异。
- 生殖系统 /
- 恶性肿瘤 /
- 死亡率 /
- 趋势分析
Abstract: Objective To describe and analyze the level and variation trend of mortality of female genital malignancies in China from 2004 to 2016, so as to provide scientific evidence for the formulation and implementation of cancer prevention and control measures. Methods The mortality data of cervical cancer, corpus cancer and ovarian cancer were selected from the mortality monitoring data of the national disease monitoring system, the crude mortality and standardized mortality rates were calculated respectively, the annual change trend was analyzed by Joinpoint software. Results From 2004 to 2016, the mortality rate of cervical cancer in Chinese women increased significantly. The mortality trend obviously accelerated after 2011(annual percent change, APC=13.7%), and the mortality rate in rural areas was higher than that in urban areas. The mortality rate of corpus cancer was relatively stable, and showed a downward trend after 2013(APC=-23.5%). Ovarian cancer mortality rate slightly increased, but the death trend was not statistically significant. Conclusions From 2004 to 2016, the mortality of corpus cancer in Chinese women had improved, the mortality of cervical cancer was still relatively serious, and there were differences between urban and rural areas.
- Reproductive system /
- Malignant tumor /
- Mortality rate /
- Trend analysis

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图 1 中国女性宫颈癌死亡率变化情况(分年龄)

Figure 1. Changes of cervical cancer mortality in Chinese women(age)

下载: 全尺寸图片幻灯片

图 2 中国女性宫体癌死亡率变化情况(分年龄)

Figure 2. Changes of corpus cancer mortality in Chinese women(age)

下载: 全尺寸图片幻灯片

图 3 中国女性卵巢癌死亡率变化情况(分年龄)

Figure 3. Changes of ovarian cancer mortality in Chinese women(age)

下载: 全尺寸图片幻灯片

图 4 中国女性生殖系统恶性肿瘤死亡率变化情况

Figure 4. Changes of mortality rate of female reproductive system cancer in China

下载: 全尺寸图片幻灯片

图 5 三大恶性肿瘤死亡趋势变化

Figure 5. The death trend of cervical cancer, corpus cancer and ovarian cancer

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图 6 城市女性三大恶性肿瘤死亡趋势变化

Figure 6. The death trend of cervical cancer, corpus cancer and ovarian cancer in urban women

下载: 全尺寸图片幻灯片

图 7 农村女性三大恶性肿瘤死亡趋势变化

Figure 7. The death trend of cervical cancer, corpus cancer and ovarian cancer in rural women

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表 1 2004-2016年中国女性生殖系统恶性肿瘤死亡情况

Table 1. Death rate of female reproductive system cancer in China from 2004 to 2016

年份	宫颈癌(n=32 948)			宫体癌(n=24 046)			卵巢癌(n=15 808)
年份	死亡人数(人)	粗死亡率(1/10万)	中标率(1/10万)	死亡人数(人)	粗死亡率(1/10万)	中标率(1/10万)	死亡人数(人)	粗死亡率(1/10万)	中标率(1/10万)
2004	976	2.81	3.20	1 510	4.34	4.92	507	1.46	1.64
2005	1 019	2.92	3.30	1 511	4.33	4.92	501	1.43	1.64
2006	765	2.37	2.64	1 036	3.21	3.56	460	1.42	1.60
2007	1 027	2.94	3.20	1 244	3.56	3.91	576	1.65	1.81
2008	961	2.66	2.78	1 384	3.83	4.03	623	1.72	1.82
2009	1 067	2.90	2.92	1 371	3.73	3.75	682	1.86	1.88
2010	1 117	2.89	2.86	1 483	3.84	3.80	736	1.91	1.87
2011	1 082	2.85	2.68	1 361	3.58	3.35	677	1.78	1.65
2012	1 118	2.95	2.71	1 347	3.56	3.24	728	1.92	1.76
2013	3 648	3.27	2.87	4 027	3.61	3.13	2 089	1.87	1.62
2014	6 103	4.91	4.26	2 839	2.28	1.94	2 458	1.98	1.71
2015	6 721	5.30	4.59	2 552	2.01	1.73	2 642	2.08	1.80
2016	7 344	5.65	4.79	2 381	1.83	1.52	3 129	2.41	2.02

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表 2 2004-2016年中国女性生殖系统恶性肿瘤死亡趋势变化

Table 2. The changes of the death trend of cancer in the reproductive system of Chinese women from 2004 to 2016

分类	肿瘤类型	时间区段		APC(%)	下限	上限
监测范围	宫颈癌	2004	2011	-2.9	-10.1	4.8
		2011	2016	13.7^a	6.5	21.4
	宫体癌	2004	2013	-5.1^a	-7.3	-2.9
		2013	2016	-23.5^a	-34.0	-11.4
	卵巢癌	2004	2008	3.3	-2.0	8.8
		2008	2016	-0.4	-3.3	2.5
城市	宫颈癌	2004	2011	-0.9	-8.7	7.6
		2011	2016	12.0^a	4.1	20.4
	宫体癌	2004	2013	-4.8^a	-7.1	-2.5
		2013	2016	-17.1^a	-27.9	-4.8
	卵巢癌	2004	2014	-1.9^a	-3.5	-0.2
		2014	2016	7.1	-5.8	21.8
农村	宫颈癌	2004	2011	-3.8	-10.9	3.9
		2011	2016	14.0^a	7.2	21.2
	宫体癌	2004	2012	-3.7^a	-7.1	-0.1
		2012	2016	-22.2^a	-30.0	-13.6
	卵巢癌	2004	2012	1.6	-0.7	4.0
		2012	2016	9.0^a	6.5	11.5
注：^a：代表计算得到的APC值具有统计学意义，P＜0.05。

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