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摘要:
目的 评估自我管理模式在感染艾滋病病毒(human immunodeficiency virus,HIV)的男男同性恋人群中的实践效果,为制定该人群HIV/艾滋病(acquired immune deficiency syndrome,AIDS)综合管理策略提供依据。 方法 依托男男同性恋非政府组织(non-governmental organizations,NGOs)采用同伴推动抽样方法(respondent-driven sampling,RDS)招募研究对象,并随机分为干预组和对照组。干预组实行自我管理模式,建立自我管理小组,在慢性病自我管理(chronic disease self-management,CDSM)的理论基础上以小组为单位开展健康教育课程和同伴教育;对照组实行常规随访管理模式,即以疾控中心为主体开展的医学随访等相关活动;1年后开展效果评估。 结果 自我管理小组在健康感受、角色功能、生活质量、健康转换、心理健康5个指标的得分上有不同程度的提高。自我管理小组有焦虑症状的比例从38.6%下降到22.6%,经常使用安全套的比例从43.3%提高到47.3%,坚持服药的比例从68.2%提升到78.8%。 结论 自我管理模式可有效突破目前男男同性恋人群艾滋病管理的瓶颈,可以改善该人群的生存质量。 Abstract:Objective To evaluate practical effects of self-management model among HIV-infected men who have sex with men (MSM), and to provide evidence for the development of HIV/AIDS comprehensive management strategies for this population. Methods Respondent-driven sampling (RDS) sampling was used to recruit subjects with the help of the non-governmental organization. Selected MSM were randomly divided into intervention group and control group. The intervention group implemented a self-management model and established a self-management group to conduct health education courses and peer-education based on chronic disease self-management (CDSM) theory. The control group was organized by the center for diseases control and prevention (CDC) to carry out medical follow-up and other related activities. After one year, the evaluation survey was carried out, and the data was statistically analyzed using SPSS software. Results The CDSM team had different degrees of improvement in the scores of general health, role function, quality life, health transition and mental health sumonary scores. The proportion of self-management groups with anxiety symptoms decreased from 38.6% to 22.6%, the proportion of condom use increased from 43.3% to 47.3%, and the proportion of adherence to medication increased from 68.2% to 78.8%. Conclusion The self-management model can effectively break through the bottleneck of HIV/AIDS management for MSM and can improve quality of life of them. -
Key words:
- HIV /
- MSM /
- Self-management model
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表 1 生存质量各维度评分(x±s)
Table 1. Dimension scores of QOL(x±s)
条目 评分 干预组 对照组 P值 GH 60.35±16.90 60.48±16.18 60.21±17.62 0.874 PF 81.49±22.82 82.34±21.66 80.63±23.94 0.442 RF 89.76±26.80 92.14±24.89 87.38±28.44 0.069 SF 82.09±22.01 83.71±20.41 80.47±23.43 0.132 CF 77.75±18.98 79.85±16.78 75.64±20.78 0.023 PN 88.07±14.37 88.20±14.13 87.93±14.63 0.851 MH 65.28±16.86 66.95±16.18 63.60±17.06 0.042 VT 62.08±17.01 63.28±17.74 60.88±17.62 0.164 HD 75.02±20.50 77.00±19.16 73.04±21.61 0.048 QL 68.21±15.11 70.36±14.85 66.07±15.09 0.004 HT 68.57±24.00 69.40±23.74 67.74±24.29 0.477 PHSS 53.70±8.52 54.46±8.04 52.94±8.93 0.067 MHSS 49.94±8.79 51.06±8.17 48.82±9.26 0.009 表 2 干预组和对照组人口学特征[n(%)]
Table 2. Demographic characteristics of intervention and control group [n(%)]
人口学特征 n(%) 干预组(n=210) 对照组(n=210) P值 年龄(岁) 0.213 15~ 36(8.6) 15(7.1) 21(10.0) 25~ 203(48.4) 97(46.2) 106(50.5) 35~ 87(20.7) 52(24.8) 35(16.7) 45~ 46(10.9) 25(11.9) 21(10.0) ≥55 48(11.4) 21(10.0) 27(12.8) 婚姻状况 0.112 未婚 248(59.1) 116(55.2) 132(62.9) 在婚 172(40.9) 94(44.8) 78(37.1) 个人月收入(元) 0.029 <2 000 60(14.3) 39(18.6) 21(10.0) 2 000~ 87(20.7) 48(22.8) 39(18.6) 4 000~ 99(23.6) 44(21.0) 55(26.2) ≥6 000 174(41.4) 79(37.6) 95(45.2) 文化程度 0.056 初中及以下 78(18.6) 49(23.3) 30(14.3) 高中或中专 69(16.5) 34(16.2) 35(16.7) 大专及以上 272(64.9) 127(60.5) 145(69.0) 户籍 0.694 是 234(55.7) 95(45.2) 91(43.3) 否 186(44.3) 115(54.8) 119(56.7) 表 3 基于QOL指标的CDSM效果评估
Table 3. Evaluation of CDSM effects based on QOL indicators
评价指标 分组 基线(x±s) 终末(x±s) 差值(95%CI) P值 前后 组间 GH I 60.48±16.18 64.90±17.94 4.42(1.46~7.38) 0.004 0.063 C 60.21±17.62 61.95±16.18 1.74(-1.26~4.74) 0.257 PF I 82.34±21.66 84.91±30.21 2.57(-4.03~5.54) 0.091 0.033 C 80.63±23.94 81.52±29.31 0.89(-2.11~3.89) 0.562 RF I 92.14±24.89 97.09±52.42 4.95(1.98~7.93) 0.001 0.134 C 87.38±28.44 94.71±42.28 7.33(4.32~10.33) < 0.001 SF I 83.71±20.41 80.96±29.22 -2.75(-5.72~0.22) 0.071 0.060 C 80.47±23.43 77.97±20.20 -2.50(-5.50~0.50) 0.104 CF I 79.85±16.78 76.63±22.40 -3.22(6.19~-2.45) 0.034 0.045 C 75.64±20.78 73.45±13.46 -2.19(-5.19~0.81) 0.154 PN I 88.20±14.13 86.45±18.23 -1.75(-4.72~1.22) 0.249 0.738 C 87.93±14.63 85.92±13.14 -2.01(-5.01~0.99) 0.191 MH I 66.95±16.18 65.36±17.56 -1.59(-4.56~1.38) 0.295 0.091 C 63.60±17.06 62.68±16.48 -0.92(-3.92~2.08) 0.549 VT I 63.28±17.74 62.65±19.39 -0.63(-3.60~2.34) 0.678 0.038 C 60.88±17.62 59.36±16.68 -1.52(-4.53~1.48) 0.322 HD I 77.00±19.16 75.05±22.72 -1.95(-4.92~1.02) 0.199 0.007 C 73.04±21.61 70.79±15.84 -2.25(-5.25~0.75) 0.143 QL I 70.36±14.85 79.82±20.80 9.46(6.48~12.43) < 0.001 < 0.001 C 66.07±15.09 71.82±15.86 5.75(2.74~8.75) < 0.001 HT I 69.40±23.74 74.85±24.92 5.45(2.48~8.42) < 0.001 < 0.001 C 67.74±24.29 67.85±24.04 0.11(-2.89~3.11) 0.943 PHSS I 54.46±8.04 55.55±9.41 1.49(-1.48~4.46) 0.327 0.210 C 52.94±8.93 53.56±6.48 0.62(-2.38~3.62) 0.686 MHSS I 51.06±8.17 59.95±10.33 8.89(5.92~11.86) < 0.001 < 0.001 C 48.82±9.26 51.25±7.49 2.43(-0.57~5.43) 0.114 注:I干预组,C对照组。 表 4 相关指标的CDSM效果评估[n(%)]
Table 4. CDSM effect evaluation based on related indicators [n(%)]
评价指标 干预组[n(%)] P值 对照组[n(%)] P值 基线 终末a 基线 终末a 抑郁 0.381 0.370 正常 178(84.7) 149(80.1) 166(79.0) 147(85.0) 轻度 26(12.4) 33(17.7) 32(15.2) 16(9.2) 中度 5(2.4) 4(2.2) 11(5.2) 9(5.2) 重度 1(0.5) 0(0.0) 1(0.5) 1(0.6) SAS 0.002 0.433 正常 129(61.4) 144(77.4) 148(70.5) 126(72.8) 轻度 72(34.3) 39(21.0) 50(23.8) 43(24.9) 中度 9(4.3) 2(1.1) 9(4.3) 3(1.7) 重度 0(0.0) 1(0.5) 3(1.4) 1(0.6) 安全套使用 0.034 0.044 从不 29(13.8) 11(5.9) 30(14.3) 12(6.9) 偶尔 90(42.9) 87(46.8) 79(37.6) 62(35.8) 经常 91(43.3) 88(47.3) 101(48.1) 99(57.2) 治疗依从性 0.046 0.016 能坚持按时服药 101(68.2) 108(78.8) 104(63.0) 121(75.6) 不能坚持 47(31.8) 29(21.2) 61(37.0) 39(24.2) 注:a干预组(N=186),对照组(N=173)。 -
[1] 胡晓松, 赵燕, 吴尊友. 云南省文山州HIV感染者抗病毒治疗脱失影响因素的定性研究[J]. 中华疾病控制杂志, 2018, 22(08): 822-825. DOI: 10.16462/j.cnki.zhjbkz.2018.08.014.Hu XS, Zhao Y, Wu ZY. Qualitative study of factors associated with antiretroviral therapy drop-out among HIV-infected patients in Wenshan prefecture, Yunnan Province[J]. Chin J Dis Control Prev, 2018, 22(08): 822-825. DOI: 10.16462/j.cnki.zhjbkz.2018.08.014. [2] 朱志伟, 范引光, 冯献湘, 等. 柳州市女性HIV/AIDS抗病毒治疗后CD4变化情况及其影响因素研究[J]. 中华疾病控制杂志, 2018, 22(5): 445-449. DOI: 10.16462/j.cnki.zhjbkz.2018.05.004.Zhu ZW, Fan YG, Feng XX, et al. Influencing factors of CD4+ T-cell counts change among HIV/AIDS patients after highly active antiretroviral treatment in Liuzhou[J]. Chin J Dis Control Prev, 2018, 22(5): 445-449. DOI: 10.16462/j.cnki.zhjbkz.2018.05.004. [3] 王莹莹, 杨海涛, 王永红, 等. 石家庄市358例艾滋病患者抗逆转录病毒治疗后生存分析及危险因素研究[J]. 中华疾病控制杂志, 2018, 22(3): 258-261. DOI: 10.16462/j.cnki.zhjbkz.2018.03.011.Wang YY, Yang HT, Wang YH, et al. Survival rate and risk factors of mortality among 358 adult HIV/AIDS patients receiving highly active antiretroviral therapy in Shijiazhuang[J]. Chin J Dis Control Prev, 2018, 22(3): 258-261. DOI: 10.16462/j.cnki.zhjbkz.2018.03.011. [4] 徐鹏, 张大鹏, 马福昌, 等. 卫生系统内艾滋病防治工作的主要问题、原因及解决思路[J]. 中国卫生政策研究, 2014, 7(10): 68-72. DOI: 10.3969/j.issn.1674-2982.2014.10.013.Xu P, Zhang DP, Ma FC, et al. Main issues, causes and strategies for AIDS prevention and control in health care systems[J]. Chinese Journal of Health policy, 2014, 7(10): 68-72. DOI: 10.3969/j.issn.1674-2982.2014.10.013. [5] 赵烨, 马颖, 陈任, 等. 我国艾滋病防治政策分析[J]. 中国卫生事业管理, 2015, 10(2): 114-117. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWSG201502012.htmZhao Y, Ma Y, Chen R, et al. The policy analysis of HIV/AIDS prevention and control[J]. Chinese Health Service Management, 2015, 10(2): 114-117. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWSG201502012.htm [6] 吴尊友. 我国实现艾滋病防治策略三个90%的进展与挑战[J]. 中华疾病控制杂志, 2016, 20(12): 1187-1189. DOI: 10.16462/j.cnki.zhjbkz.2016.12.001.Wu ZY. The progress and challenges of promoting HIV/AIDS 90-90-90 strategies in China[J]. Chin J Dis Control Prev, 2016, 20(12): 1187-1189. DOI: 10.16462/j.cnki.zhjbkz.2016.12.001. [7] 黄凌, 杨晴, 胡强, 等. 江西省艾滋病随访管理下沉工作现况分析与探讨[J]. 中华疾病控制杂志, 2017, 21(12): 1298-1300. DOI: 10.16462/j.cnki.zhjbkz.2017.12.026.Huang L, Yang Q, Hu Q, et al. Analysis on the situation of the AIDS follow-up management of HIV/AIDS in Jiangxi Province[J]. Chin J Dis Control Prev, 2017, 21(12): 1298-1300. DOI: 10.16462/j.cnki.zhjbkz.2017.12.026. [8] Barlow J, Wright C, Sheasby J, et al. Self-management approaches for people with chronic conditions: a review[J]. Patient Educ Couns, 2002, 48(2): 177-187. doi: 10.1016/S0738-3991(02)00032-0 [9] Doulton TW, Farmer CK, Stevens PE. Self-management in chronic disease: clear benefits for blood pressure control in CKD[J]. Am J Kidney Dis, 2015, 66(1): 12-14. DOI: 10.1053/j.ajkd.2015.01.006. [10] Cannon D, Buys N, Sriram KB, et al. The effects of chronic obstructive pulmonary disease self-management interventions on improvement of quality of life in COPD patients: a meta-analysis[J]. Respir Med, 2016, 121(12): 81-90. DOI:10.1016/j.rmed.2016.11.005.Epub 2016 Nov 3. [11] Liu J, Qu B, Zhu Y, et al. The influence of social support on quality of life of men who have sex with men in China: a preliminary study[J]. PLoS One, 2015, 10(5): e0127644. DOI: 10.1371/journal.pone.0127644. [12] 陈冬华, 周仁义, 王晋生, 等. 山西省农村地区艾滋病病毒感染者生活质量研究[J]. 中华疾病控制杂志, 2010, 14(2): 138-141. http://zhjbkz.ahmu.edu.cn/article/id/JBKZ201002013Chen DH, Zhou RY, Wang JS, et al. Study on quality of life among people living with HIV/AIDS in rural areas in Shanxi Province[J]. Chin J Dis Control Prev, 2010, 14(2): 138-141. http://zhjbkz.ahmu.edu.cn/article/id/JBKZ201002013 [13] Zhu Y, Liu J, Qu B, et al. Relationship between quality of life and unprotected anal intercourse among Chinese men who have sex with men: a cross-sectional study[J]. BMC Public Health, 2016, 16: 382. DOI: 10.1186/s12889-016-3076-z. [14] 李欢龙, 刘丹丹, 陈昌可, 等. 艾滋病防治"富阳模式"探索[J]. 中国健康教育, 2015, 31(10): 997-999. DOI: 10.16168/j.cnki.issn.1002-9982.2015.10.024.Li HL, Liu DD, Chen CK, et al. Implementation of "Fuyang model" on AIDS prevention and cure[J]. Chinese Journal of Health Education, 2015, 31(10): 997-999. DOI: 10.16168/j.cnki.issn.1002-9982.2015.10.024. [15] 梁辉, 陈任, 王丹妮, 等. 基于中国全球基金艾滋病项目的社区组织管理模式探讨[J]. 中国卫生事业管理, 2016, 31(1): 4-6. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWSG201601004.htmLiang H, Chen R, Wang DN, et al. Discussing on the community-based organization management model based on China global fund AIDS program[J]. Chinese Health Service Management, 2016, 31(1): 4-6. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWSG201601004.htm