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妇女孕前和孕期维生素D水平及影响因素

张玉,  武常倩,  马晓英,  喇雪娜,  张妍,  毛红芳,  蔡徐山,  吴守乐,  尹东晓,  蒋泓

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文章导航 > 中华疾病控制杂志  > 2020 >  24(1): 41-45
张玉, 武常倩, 马晓英, 喇雪娜, 张妍, 毛红芳, 蔡徐山, 吴守乐, 尹东晓, 蒋泓. 妇女孕前和孕期维生素D水平及影响因素[J]. 中华疾病控制杂志, 2020, 24(1): 41-45. doi: 10.16462/j.cnki.zhjbkz.2020.01.009
引用本文: 张玉, 武常倩, 马晓英, 喇雪娜, 张妍, 毛红芳, 蔡徐山, 吴守乐, 尹东晓, 蒋泓. 妇女孕前和孕期维生素D水平及影响因素[J]. 中华疾病控制杂志, 2020, 24(1): 41-45. doi: 10.16462/j.cnki.zhjbkz.2020.01.009
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ZHANG Yu, WU Chang-qian, MA Xiao-ying, LA Xue-na, ZHANG Yan, MAO Hong-fang, CAI Xu-shan, WU Shou-le, YIN Dong-xiao, JIANG Hong. Study on the levels and risk factors of Vitamin D from preconception to pregnancy[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(1): 41-45. doi: 10.16462/j.cnki.zhjbkz.2020.01.009
Citation: ZHANG Yu, WU Chang-qian, MA Xiao-ying, LA Xue-na, ZHANG Yan, MAO Hong-fang, CAI Xu-shan, WU Shou-le, YIN Dong-xiao, JIANG Hong. Study on the levels and risk factors of Vitamin D from preconception to pregnancy[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(1): 41-45. doi: 10.16462/j.cnki.zhjbkz.2020.01.009
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妇女孕前和孕期维生素D水平及影响因素

doi: 10.16462/j.cnki.zhjbkz.2020.01.009
  • 1.

    200032 上海, 复旦大学公共卫生学院妇幼与儿少卫生教研室国家卫生健康委员会卫生技术评估重点实验室

  • 2.

    201899 上海, 上海市嘉定区疾病预防控制中心

  • 3.

    201812 上海, 上海市嘉定区妇幼保健院

基金项目: 国家自然科学基金(81973057);上海市第四轮公共卫生三年行动计划重点学科建设资助(15GWZK0402);上海市高峰学科建设, 上海市高水平地方高校建设, 上海市自然科学基金(19ZR1405900)
详细信息
    通讯作者:

    蒋泓, E-mail:h_jiang@fudan.edu.cn

  • 中图分类号: R181.2

Study on the levels and risk factors of Vitamin D from preconception to pregnancy

  • 1.

    Department of Maternal, Child and Adolescent Healthy School of Public Healthy NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai 200032, China

  • 2.

    Jiading District Center for Disease Control and Prevention, Shanghai 201899, China

  • 3.

    Maternal and Child Health Care Hospital of Jiading District, Shanghai 201812, China

Funds: National Natural Science Foundation of China(81973057); The Fourth Round of Three-year Action Plan and Key Discipline Program on Public Health System Establishment of Shanghai(15GWZK0402); Peak Discipline Establishment of Shanghai、Shanghai High-level University Capacity Building and Discipline Development Project、Natural Science Foundation of Shanghai(19ZR1405900)
More Information

    摘要
  • 摘要:   目的   了解上海市嘉定区妇女孕前、孕中期和孕晚期体内维生素D(Vitamin D, VD)水平的现状, 探讨孕中期和孕晚期VD水平的影响因素。   方法   选取2016年9月至2018年12月在上海市嘉定区妇幼保健院参加孕前检查并随访到分娩的94名妇女为研究对象, 采用化学发光法检测孕前、中期和晚期血清中的VD水平, 共检测282份血清。   结果   94名妇女的孕前、孕中期和晚期的VD缺乏率分别为:40.4%、57.4%和48.9%。混合线性模型结果显示, 近1年内有过染发/烫发的妇女孕期血清VD水平较低(P < 0.05), 孕期经常喝牛奶和吃深海鱼的妇女在孕期VD水平较高(P < 0.05)。   结论   上海嘉定区妇女孕前和孕期VD缺乏普遍, 应该重视在孕前和孕期VD的补充。
    Abstract:   Objective   To investigate the levels of serum Vitamin D(VD) from preconception to pregnancy in Jiading district of Shanghai, and explore the risk factors of VD concentration deficiency in the second and third trimester of pregnancy.   Methods   A total of 94 women who planned to have antenatal care and delivery in Maternal and Child Health Hospital of Jiading district of Shanghai from September 2016 to December 2018 were recruited as the study participants. Chemiluminescent immunoassay(CLIA) was used to examine the concentration of women's serum VD from preconception to pregnancy. A total of 282 serum samples were detected.   Results   The prevalence of VD deficiency among 94 women from preconception to pregnancy were 40.4%, 57.4% and 48.9% respectively.   Results   of the mixed linear model showed that women who had dyed or permed hair within the past 1 year had significantly lower serum VD levels during pregnancy(P < 0.05), and women who often drank milk and ate deep-sea fish during pregnancy had higher VD levels during pregnancy(P < 0.05).   Conclusions   VD deficiency was common among women in Jiading district of Shanghai, and it should be emphasized to supplement VD before and during pregnancy.
    • HTML全文

  • 表  1  94名妇女的基本情况

    Table  1.   Characteristics of women (n=94)

    变量 n(%) 变量 n(%)
    孕前年龄(岁) 孕期维生素补充
    < 28 44(46.8) 是 72(76.6)
    ≥28 50(53.2) 否 22(23.4)
    孕前BMI(kg/m2) 钙/铁/锌剂补充
    偏瘦 < 18.5 16(17.0) 是 76(80.9)
    正常18.5~ 68(72.3) 否 18(19.1)
    超重≥24.0 10(10.6) 孕期叶酸补充
    户籍所在地 是 72(76.6)
    上海 55(58.9) 否 22(33.4)
    非上海 39(41.1) 孕期新鲜蔬菜摄入(次/每周)
    文化程度 ≥4 92(97.9)
    大学以下 28(29.8) < 4 2(2.1)
    大学及以上 66(70.2) 孕期牛奶摄入(次/每周)
    家庭人均年收入(万元) ≥4 54(57.4)
    < 10 37(39.4) < 4 40(42.6)
    ≥10 57(60.6) 孕期畜肉摄入(次/每周)
    孕前饮酒 ≥4 58(61.7)
    是 14(14.9) < 4 36(38.3)
    否 80(85.1) 孕期深海鱼摄入(次/每周)
    孕前被动吸烟 ≥4 14(14.9)
    是 30(31.9) < 4 80(85.1)
    否 64(68.1) 孕期虾蟹贝类摄入(次/每周)
    近1年内烫/染发 ≥4 77(81.9)
    是 34(36.2) < 4 17(18.1)
    否 60(63.8) 孕期蛋类摄入(次/每周)
    孕期鱼肝油补充 ≥4 70(74.5)
    是 52(55.3) < 4 24(25.5)
    否 42(44.7)
    下载: 导出CSV

    表  2  妇女孕前、孕中期和孕晚期维生素D水平的分布[n(%)]

    Table  2.   Concentrations of VD in women's serum from preconception to third trimester [n(%)]

    时期 总体M(P25, P75) VD水平分组
    充足 不足 缺乏
    孕前 20.97(17.55, 24.58) 8(8.5) 48(51.1) 38(40.4)
    孕中期 18.68(15.99, 23.27) 6(6.4) 34(36.2) 54(57.4)
    孕晚期 20.37(14.85, 26.16) 11(11.7) 37(39.4) 46(48.9)
    F/χ2值 5.998a 4.907b
    P值 0.050 0.086
    注:ab采用Kruskal-Wallis H检验。
    下载: 导出CSV

    表  3  妇女孕中期和孕晚期VD水平影响因素的混合线性模型分析

    Table  3.   The analysis on influencing factors of Vitamin D concentration during the second and third trimester by mixed linear model

    分组 β值 95%CI值 Sx t值 P值
    孕期
        中期 Ref.
        晚期 1.22 -0.25~2.69 0.74 1.65 0.103
        孕前VD浓度 0.07 -0.05~0.20 0.06 1.15 0.255
    孕前年龄(岁)
         < 28 Ref.
        ≥28 0.67 -1.48~2.82 1.08 0.62 0.536
    孕前BMI
         < 18.5 0.75 -1.97~3.47 1.37 0.55 0.586
        18.5~ Ref.
        ≥24.0 -1.91 -5.17~1.34 1.64 -1.17 0.246
    文化程度
        大学以下 Ref.
        大学及以上 -0.80 -3.19~1.59 1.20 -0.67 0.505
    家庭人均年收入(万元)
         < 10 Ref.
        ≥10 1.79 -0.52~4.10 1.16 1.54 0.127
    近1年内烫发/染发
        是 -2.68 -4.89~-0.48 1.11 -2.43 0.018a
        否 Ref.
    孕期鱼肝油补充
        是 1.57 -0.64~3.78 1.11 1.41 0.162
        否 Ref.
    孕期维生素补充
        是 -0.48 -3.61~2.66 1.57 -0.30 0.764
        否 Ref.
    钙/铁/锌剂补充
        是 0.97 -1.91~3.84 1.44 0.67 0.505
        否 Ref.
    孕期叶酸补充
        是 2.03 -1.09~5.15 1.57 1.30 0.199
        否 Ref.
    孕期新鲜蔬菜摄入
    (次/每周)
        ≥4 5.20 -1.83~12.24 3.53 1.47 0.145
         < 4 Ref.
    孕期牛奶摄入(次/每周)
        ≥4 2.59 0.47~4.71 1.07 2.43 0.017a
         < 4 Ref.
    孕期畜肉摄入(次/每周)
        ≥4 -1.19 -3.55~1.17 1.19 -1.01 0.317
         < 4 Ref.
    孕期深海鱼摄入(次/每周)
        ≥4 6.62 0.26~12.99 3.20 2.07 0.042a
         < 4 Ref.
    孕期虾蟹贝类摄入(次/每周)
        ≥4 -4.89 -10.85~1.06 2.99 -1.64 0.106
         < 4 Ref.
    孕期蛋类摄入(次/每周)
        ≥4 1.85 -0.53~4.24 1.20 1.55 0.126
         < 4 Ref.
    注：a表示P<0.05。
    下载: 导出CSV
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