吸烟对慢性阻塞性肺疾病及呼吸道症状的影响

查震球; 何玉琢; 徐伟; 陈叶纪; 刘心勇; 刘志荣; 叶冬青

doi:10.16462/j.cnki.zhjbkz.2020.01.010

吸烟对慢性阻塞性肺疾病及呼吸道症状的影响

doi: 10.16462/j.cnki.zhjbkz.2020.01.010

1.
230601 合肥, 安徽省疾病预防控制中心慢性非传染性疾病防治科
2.
245000 黄山, 黄山市疾病预防控制中心
3.
230032 合肥, 安徽医科大学公共卫生学院流行病与卫生统计学系

基金项目: 国家重点研发计划项目(2016YFC1303905);安徽省科技重大专项计划项目(201903a07020015)

详细信息

通讯作者:
刘志荣, E-mail:lzr@ahcdc.com.cn

叶冬青, E-mail:ydq@ahmu.edu.cn

中图分类号: R181.2;R562
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- 被引次数: 0
出版历程
- 收稿日期: 2019-07-19
- 修回日期: 2019-10-08
- 刊出日期: 2020-01-10

Effects of smoking on chronic obstructive pulmonary disease and respiratory symptoms

1.
Anhui Provincial Center for Disease Control and Prevention, Hefei 230601, China
2.
Huangshan Center for Disease Control and Prevention, Huangshan 245000, China
3.
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei 230032, China

Funds: National Key Research and Development Program(2016YFC1303905); Major Science and Technology Plan Project of Anhui Province(201903a07020015)

More Information

Corresponding author: LIU Zhi-rong, E-mail:lzr@ahcdc.com.cn; YE Dong-qing, E-mail:ydq@ahmu.edu.cn

摘要

摘要: 目的探讨吸烟对慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)及呼吸道症状的影响。方法利用多阶段分层整群随机抽样的方法在安徽5个COPD监测点抽取≥40岁调查对象, 并对其进行问卷调查、身体测量和肺功能检测。利用复杂抽样Logistic回归分析模型分析吸烟对COPD及呼吸道症状的影响。结果 ≥30包年的吸烟者在总人群中占13.9%(95% CI:10.3%~17.5%, P < 0.001), ≥40年的吸烟者在总人群中占8.5%(95% CI:6.7%~10.3%, P < 0.001)。吸烟者平均吸烟年数为32.4 (95% CI:31.2~33.5)年, 吸烟者日均吸烟量为21.1 (95% CI:19.6~22.7)支/天。调整混杂因素后, COPD和呼吸道症状的患病风险均随吸烟包年和吸烟年数的增加而呈上升趋势(均有P_trend < 0.001)。结论吸烟增加COPD及呼吸道症状的患病风险, 吸烟包年和吸烟年数越多, 慢阻肺和呼吸道症状的患病风险越大。
- 吸烟 /
- 慢性阻塞性肺疾病 /
- 呼吸道症状 /
- 横断面研究 /
- 流行病学
Abstract: Objective To investigate the effects of smoking on chronic obstructive pulmonary disease(COPD) and respiratory symptoms. Methods A multi-stage, stratified cluster sampling strategy was used to select participants aged 40 or older in 5 surveillance points of Anhui Province. Questionnaires, body measurements and spirometry were used to collect data. Based on complex sampling design, Logistic regression model was conducted to analyze the effects of smoking on COPD and respiratory symptoms. Results The smokers who had smoked for ≥30 pack-years accounted for 13.9%(95% CI:10.3%-17.5%, P < 0.001) of the total population. And the smokers who had smoked for ≥40 years accounted for 8.5%(95%CI:6.7%-10.3%, P < 0.001) of the total population. On average, one smoker had smoked for 32.4 years(95%CI:31.2-33.5). Average daily cigarette consumption of daily smokers was 21.1 cigarettes(95% CI:19.6-22.7). As shown by multiple-variables Logistic regression analyses, the risk of COPD and respiratory symptoms increased with the increment of smoking pack-years and duration(all P_trend < 0.001). Conclusions Smoking was associated with COPD and respiratory symptoms. The risk of developing COPD and respiratory symptoms was greater with the increment of smoking pack-years and duration.
- Smoking /
- Chronic obstructive pulmonary disease /
- Respiratory symptoms /
- Cross-sectional studies /
- Epidemiology

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表 1 调查对象基本特征

Table 1. Demographic characteristics of responders

项目	合计		吸烟者(n=1 011)	从不吸烟者(n=1 754)	χ²值	P值
项目	调查人数(人)	构成比[%(95%CI)]	构成比[%(95%CI)]	构成比[%(95%CI)]	χ²值	P值
城乡
城镇	1 668	62.5(38.0~86.9)	62.7(37.2~88.1)	62.4(38.3~86.4)	0.02	0.898
乡村	1 102	37.5(13.1~62.0)	37.3(11.9~62.8)	37.6(13.6~61.7)
年龄(岁)
40~	1 047	41.0(30.6~51.3)	37.7(30.3~45.2)	42.8(30.0~55.7)	13.25	0.001
50~	788	30.1(25.0~35.1)	27.4(21.4~33.4)	31.6(25.0~38.1)
≥60	935	29.0(18.5~39.5)	34.9(23.3~46.5)	25.6(15.1~36.1)
性别
男	1 362	48.1(42.2~54.0)	96.0(93.5~98.4)	20.9(13.5~28.3)	340.60	< 0.001
女	1 408	51.9(46.0~57.8)	4.0(1.6~6.5)	79.1(71.7~86.5)
教育水平
小学及以下	1 690	57.5(45.5~69.5)	46.1(36.9~55.4)	63.9(51.4~76.4)	67.98	< 0.001
初中毕业	774	29.2(25.4~33.0)	36.7(23.6~49.9)	25.0(21.5~28.4)
高中及以上	305	13.3(0.0~27.4)	17.1(0.0~35.2)	11.1(0.0~22.6)
儿童期严重呼吸系统感染
无	2 716	98.1(97.1~99.0)	97.8(95.5~100.0)	98.2(97.3~99.1)	0.25	0.618
有	53	1.9(1.0~2.9)	2.2(0.0~4.5)	1.8(0.9~2.7)
肺结核病史
无	2 723	98.5(97.5~99.6)	98.3(96.6~100.0)	98.6(97.6~99.6)	0.44	0.505
有	46	1.5(0.4~2.5)	1.7(0.0~3.4)	1.4(0.4~2.4)
呼吸病家族史
无	2 276	80.3(74.0~86.7)	77.1(70.5~83.6)	82.3(76.0~88.6)	26.23	< 0.001
有	493	19.7(13.3~26.0)	22.9(16.4~29.5)	17.7(11.4~24.0)
BMI (kg/m²)
< 18.5	42	1.5(0.0~3.3)	1.6(0.0~3.3)	1.4(0.0~3.3)	2.15	0.341
18.5~	1 173	41.7(31.1~52.4)	43.4(36.7~50.0)	40.8(27.4~54.2)
≥24.0	1 555	56.8(44.4~69.2)	55.1(46.9~63.2)	57.8(42.7~73.0)
职业粉尘和/或有害气体暴露
无	1 571	58.2(41.7~74.7)	52.2(34.5~70.0)	61.6(44.7~78.5)	5.74	0.017
有	1 198	41.8(25.3~58.3)	47.8(30.0~65.5)	38.4(21.5~55.3)
被动吸烟
无	1 360	43.1(19.8~66.3)	33.9(12.3~55.5)	48.3(22.6~74.0)	6.42	0.011
有	1 409	56.9(33.7~80.2)	66.1(44.5~87.7)	51.7(26.0~77.4)
室内空气污染
否	1 502	50.3(7.9~92.6)	48.4(11.6~85.3)	51.3(5.7~96.9)	0.57	0.449
是	1 267	49.7(7.4~92.1)	51.6(14.7~88.4)	48.7(3.1~94.3)
合计	2 770	100.0		36.3(27.5~45.1)		63.7(54.9~72.5)

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表 2 调查对象的吸烟状况

Table 2. Smoking status of the respondents

项目	合计		城镇	乡村	P值
项目	调查人数(人)	%(95%CI)	%(95%CI)	%(95%CI)	P值
吸烟(包年)
0	1 754	64.9(55.3~74.5)	64.7(56.0~73.4)	65.3(53.3~77.3)	0.053
< 15	269	10.9(7.8~13.9)	12.2(7.5~16.8)	8.7(5.9~11.5)
< 30	297	10.3(6.1~14.5)	10.0(5.6~14.4)	10.8(7.2~14.4)
≥30	398	13.9(10.3~17.5)	13.1(11.4~14.9)	15.2(8.6~21.8)
吸烟年数(年)
0	1 754	65.2(56.2~74.2)	65.0(56.7~73.3)	65.5(54.3~76.8)	0.479
< 30	422	16.2(9.3~23.0)	16.1(8.6~23.7)	16.2(9.9~22.5)
< 40	276	10.2(8.0~12.3)	10.9(8.2~13.6)	8.9(6.4~11.5)
≥40	261	8.5(6.7~10.3)	8.0(6.7~9.2)	9.3(4.3~14.4)
吸烟者吸烟年数(年)^a	959	32.4(31.2~33.5)	32.2(29.7~34.6)	32.7(31.1~34.3)	0.702
每日吸烟者日均吸烟量(支/天)^a	905	21.1(19.6~22.7)	20.8(18.9~22.7)	21.6(20.2~23.1)	0.201
吸烟者开始吸烟年龄(岁)^a	960	21.1(18.9~23.4)	20.9(19.9~22.0)	21.4(16.6~26.2)	0.773
开始每日吸烟年龄(岁)^a	885	23.6(21.5~25.7)		23.6(21.9~25.3)		23.7(18.7~28.8)	0.952
注：^a括号外数据为相应变量的均数，括号内数据为95% CI。%(95% CI)为经抽样权重和无应答权重计算后的数值。

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表 3 不同吸烟状态者的COPD及呼吸道症状患病率[% (95% CI)]

Table 3. Prevalence of COPD and respiratory symptoms of different smoking status[% (95% CI)]

项目	COPD	轻度COPD	中重度COPD	有呼吸道症状
吸烟(包年)
0	5.6(3.0~8.2)	4.6(1.7~7.5)	1.0(0.4~1.6)	9.1(6.1~12.1)
< 15	12.5(4.5~20.4)	10.4(3.7~17.2)	2.0(0.0~4.9)	8.9(2.2~15.7)
< 30	12.1(5.4~18.9)	8.0(3.9~12.2)	4.1(0.5~7.7)	11.7(4.7~18.8)
≥30	26.6(17.6~35.6)	20.0(12.9~27.2)	6.6(2.3~10.8)	22.5(13.0~31.9)
趋势性χ²检验	76.42	35.57	132.69	101.51
P_trend值	< 0.001	< 0.001	< 0.001	< 0.001
吸烟年数(年)
0	5.6(3.0~8.2)	4.6(1.7~7.5)	1.0(0.4~1.6)	9.1(6.1~12.1)
< 30	8.0(5.4~10.6)	6.3(4.4~8.2)	1.7(0.1~3.2)	9.4(5.4~13.3)
< 40	17.1(10.5~23.7)	13.1(7.8~18.4)	4.0(0.0~8.9)	17.1(12.7~21.4)
≥40	38.3(24.9~51.7)	26.7(14.9~38.5)	11.6(6.9~16.3)	24.1(9.5~38.7)
趋势性χ²检验	95.70	31.15	76.07	25.53
P_trend值	< 0.001	< 0.001	< 0.001	< 0.001
注：%(95% CI)为经抽样权重和无应答权重计算后的数值。

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表 4 吸烟对COPD及呼吸道症状的影响

Table 4. Effects of smoking on COPD and respiratory symptoms

项目	COPD				呼吸道症状
	单因素		多因素^a		单因素		多因素^a
	OR(95%CI)值	P值	OR(95%CI)值	P值	OR(95%CI)值	P值	OR(95%CI)值	P值
吸烟(包年)
0	1.00		1.00		1.00		1.00
< 15	2.35(1.83~3.03)	< 0.001	1.55(1.12~2.14)	0.008	1.13(0.67~1.91)	0.638	1.21(0.81~1.81)	0.345
< 30	3.23(1.98~5.26)	< 0.001	2.16(1.39~3.36)	0.001	1.59(1.08~2.33)	0.019	1.87(1.16~3.01)	0.010
≥30	5.82(4.21~8.05)	< 0.001	2.57(1.96~3.37)	< 0.001	2.68(2.10~3.43)	< 0.001	2.18(1.33~3.58)	0.002
P_trend值	< 0.001		< 0.001		< 0.001		0.002
吸烟年数(年)
0	1.00		1.00		1.00		1.00
< 30	1.74(1.20~2.51)	0.003	1.41(1.07~1.85)	0.015	1.12(0.92~1.37)	0.248	1.43(0.92~2.22)	0.112
< 40	4.39(3.46~5.59)	< 0.001	2.30(1.89~2.80)	< 0.001	2.11(1.57~2.84)	< 0.001	2.00(1.45~2.77)	< 0.001
≥40	7.99(4.68~13.63)	< 0.001	2.76(1.64~4.64)	0.001	3.00(2.04~4.42)	< 0.001	2.08(1.30~3.32)	0.002
P_trend值	< 0.001			< 0.001			< 0.001		0.001
注：^a表示调整城乡、年龄、性别、教育水平、BMI、儿童期严重呼吸系统感染、肺结核病史、呼吸病家族史、职业粉尘和/或有害气体暴露、被动吸烟、室内空气污染。吸烟量、吸烟年数分别进行多因素分析。

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参考文献(25)

[1]	GOLD. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease(2019Report)[EB/OL]. (2018-11-14)[2019-3-12]. https://goldcopd.org/wp-content/uploads/2018/11/GOLD-2019-v1.7-FINAL-14Nov2018-WMS.pdf.
[2]	Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030[J]. PLoS Med, 2006, 3(11): e442. DOI:10.1371/journal.pmed.0030442" target="_blank">https://doi.org/ 10.1371/journal.pmed.0030442.
[3]	中国疾病预防控制中心慢性非传染性疾病预防控制中心.中国死因监测数据集(2016)[M].北京: 中国科学技术出版社, 2017. Chinese Center for Disease Control and Prevention. Chinese cause of death surveillance database(2016)[M]. Beijing: Science and technology of China press, 2017.
[4]	Fang L, Gao P, Bao H, et al. Chronic obstructive pulmonary disease in China: a nationwide prevalence study[J]. Lancet Respir Med, 2018, 6(6): 421-430. DOI:10.1016/S2213-2600(18)30103-6" target="_blank">https://doi.org/ 10.1016/S2213-2600(18)30103-6.
[5]	Zha Z, Leng R, Xu W, et al. Prevalence and risk factors of chronic obstructive pulmonary disease in Anhui Province, China: a population-based survey[J]. BMC Pulm Med, 2019, 19(1): 102. DOI: 10.1186/s12890-019-0864-0.
[6]	方利文, 包鹤龄, 王宝华, 等.中国居民慢性阻塞性肺疾病监测内容与方法概述[J].中华流行病学杂志, 2018, 39(5): 546-550. DOI: 10.3760/cma.j.issn.0254-6450.2018.05.002. Fang LW, Bao HL, Wang BH, et al. A summary of the methodology of the national chronic obstructive pulmonary disease surveillance in China[J]. Chin J Epidemiol, 2018, 39(5): 546-550. DOI: 10.3760/cma.j.issn.0254-6450.2018.05.002.
[7]	中华人民共和国卫生部疾病控制司.中国成人超重和肥胖症预防控制指南[M].北京: 人民卫生出版社, 2006. Department of Disease Control, Ministry of Health, People's Republic of China. Chinese adults overweight and obesity prevention and control guidelines[M]. Beijing: People's Medical Publishing House(PMPH), 2006.
[8]	王宝华, 丛舒, 包鹤龄, 等. 2014年中国40岁及以上人群粉尘和/或有害气体暴露及其防护情况分析[J].中华流行病学杂志, 2018, 39(5): 563-568. DOI: 10.3760/cma.j.issn.0254-6450.2018.05.005. Wang BH, Cong S, Bao HL, et al. Analysis on occupational exposure to dust and harmful gas and corresponding protection in adults aged 40 and older in China, 2014[J]. Chin J Epidemiol, 2018, 39(5): 563-568. DOI: 10.3760/cma.j.issn.0254-6450.2018.05.005.
[9]	Mahler DA, Wells CK. Evaluation of clinical methods for rating dyspnea[J]. Chest, 1988, 93(3): 580-586. DOI: 10.1378/chest.93.3.580.
[10]	Kohansal R, Martinez-Camblor P, Agustí A, et al. The natural history of chronic airflow obstruction revisited: an analysis of the Framingham offspring cohort[J]. Am J Respir Crit Care Med, 2009, 180(1): 3-10. DOI: 10.1164/rccm.200901-0047OC.
[11]	Zhong N, Wang C, Yao W, et al. Prevalence of chronic obstructive pulmonary disease in China: a large, population-based survey[J]. Am J Respir Crit Care Med, 2007, 176(8): 753-760. DOI: 10.1164/rccm.200612-1749OC.
[12]	Wang C, Xu J, Yang L, et al. Prevalence and risk factors of chronic obstructive pulmonary disease in China(the China Pulmonary Health[CPH]study): a national cross-sectional study[J]. Lancet, 2018, 391(10131): 1706-1717. DOI: 10.1016/s0140-6736(18)30841-9.
[13]	Bhatt SP, Kim YI, Harrington KF, et al. Smoking duration alone provides stronger risk estimates of chronic obstructive pulmonary disease than pack-years[J]. Thorax, 2018, 73(5): 414-421. DOI: 10.1136/thoraxjnl-2017-210722.
[14]	Wennergren G, Ekerljung L, Alm B, et al. Alarmingly high prevalence of smoking and symptoms of bronchitis in young women in Sweden: a population-based questionnaire study[J]. Prim Care Respir J, 2013, 22(2): 214-220. DOI: 10.4104/pcrj.2013.00043.
[15]	Langhammer A, Johnsen R, Holmen J, et al. Cigarette smoking gives more respiratory symptoms among women than among men[J]. J Epidemiol Community Health, 2000, 54(12): 917-922. DOI: 10.1136/jech.54.12.917.
[16]	Langhammer A, Johnsen R, Gulsvik A, et al. Sex differences in lung vulnerability to tobacco smoking[J]. European Respiratory Journal, 2003, 21(6): 1017-1023. DOI: 10.1183/09031936.03.00053202.
[17]	Liu Y, Pleasants RA, Croft JB, et al. Smoking duration, respiratory symptoms, and COPD in adults aged ≥45 years with a smoking history[J]. Int J Chron Obstruct Pulmon Dis, 2015, 10: 1409-1406. DOI: 10.2147/copd.s82259.
[18]	Lindström M, Kotaniemi J, Jönsson E, et al. Smoking, respiratory symptoms, and diseases: a comparative study between northern Sweden and northern Finland: report from the FinEsS study[J]. Chest, 2001, 119(3): 852-861. DOI: 10.1378/chest.119.3.852.
[19]	Urrutia I, Capelastegui A, Quintana JM, et al. Smoking habit, respiratory symptoms and lung function in young adults[J]. Eur J Public Health, 2005, 15(2): 160-165. DOI: 10.1093/eurpub/cki113.
[20]	Willemse BW, Postma DS, Timens W, et al. The impact of smoking cessation on respiratory symptoms, lung function, airway hyperresponsiveness and inflammation[J]. European Respiratory Journal, 2004, 23(3): 464-476. DOI: 10.1183/09031936.04.00012704.
[21]	Pride NB. Smoking cessation: effects on symptoms, spirometry and future trends in COPD[J]. Thorax, 2001, 56(2): 7-10.
[22]	Krzyzanowski M, Robbins DR, Lebowitz MD. Smoking cessation and changes in respiratory symptoms in two populations followed for 13 years[J]. Int J Epidemiol, 1993, 22(4): 666-673. DOI: 10.1093/ije/22.4.666.
[23]	Anthonisen NR, Connett JE, Murray RP. Smoking and lung function of lung health study participants after 11 Years[J]. Am J Respir Crit Care Med, 2002, 166(5): 675-679. DOI: 10.1164/rccm.2112096.
[24]	Shahab L, Jarvis MJ, Britton J, et al. Prevalence, diagnosis and relation to tobacco dependence of chronic obstructive pulmonary disease in a nationally representative population sample[J]. Thorax, 2006, 61(12): 1043-1047. DOI: 10.1136/thx.2006.064410.
[25]	国务院办公厅.中国防治慢性病中长期规划(2017-2025年)[EB/OL]. (2017-2-14)[2018-12-30]. http://www.gov.cn/zhengce/content/2017-02/14/content_5167886.htm#. General Office of the State Council.Chinese long-term planning for the prevention and treatment of chronic diseases (2017-2025)[EB/OL].(2017-2-14)[2018-12-30].http://www.gov.cn/zhengce/content/2017-02/14/content_5167886.htm#.

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项目	合计		吸烟者(n=1 011)	从不吸烟者(n=1 754)	χ²值	P值
项目	调查人数(人)	构成比[%(95%CI)]	构成比[%(95%CI)]	构成比[%(95%CI)]	χ²值	P值
城乡
城镇	1 668	62.5(38.0~86.9)	62.7(37.2~88.1)	62.4(38.3~86.4)	0.02	0.898
乡村	1 102	37.5(13.1~62.0)	37.3(11.9~62.8)	37.6(13.6~61.7)
年龄(岁)
40~	1 047	41.0(30.6~51.3)	37.7(30.3~45.2)	42.8(30.0~55.7)	13.25	0.001
50~	788	30.1(25.0~35.1)	27.4(21.4~33.4)	31.6(25.0~38.1)
≥60	935	29.0(18.5~39.5)	34.9(23.3~46.5)	25.6(15.1~36.1)
性别
男	1 362	48.1(42.2~54.0)	96.0(93.5~98.4)	20.9(13.5~28.3)	340.60	< 0.001
女	1 408	51.9(46.0~57.8)	4.0(1.6~6.5)	79.1(71.7~86.5)
教育水平
小学及以下	1 690	57.5(45.5~69.5)	46.1(36.9~55.4)	63.9(51.4~76.4)	67.98	< 0.001
初中毕业	774	29.2(25.4~33.0)	36.7(23.6~49.9)	25.0(21.5~28.4)
高中及以上	305	13.3(0.0~27.4)	17.1(0.0~35.2)	11.1(0.0~22.6)
儿童期严重呼吸系统感染
无	2 716	98.1(97.1~99.0)	97.8(95.5~100.0)	98.2(97.3~99.1)	0.25	0.618
有	53	1.9(1.0~2.9)	2.2(0.0~4.5)	1.8(0.9~2.7)
肺结核病史
无	2 723	98.5(97.5~99.6)	98.3(96.6~100.0)	98.6(97.6~99.6)	0.44	0.505
有	46	1.5(0.4~2.5)	1.7(0.0~3.4)	1.4(0.4~2.4)
呼吸病家族史
无	2 276	80.3(74.0~86.7)	77.1(70.5~83.6)	82.3(76.0~88.6)	26.23	< 0.001
有	493	19.7(13.3~26.0)	22.9(16.4~29.5)	17.7(11.4~24.0)
BMI (kg/m²)
< 18.5	42	1.5(0.0~3.3)	1.6(0.0~3.3)	1.4(0.0~3.3)	2.15	0.341
18.5~	1 173	41.7(31.1~52.4)	43.4(36.7~50.0)	40.8(27.4~54.2)
≥24.0	1 555	56.8(44.4~69.2)	55.1(46.9~63.2)	57.8(42.7~73.0)
职业粉尘和/或有害气体暴露
无	1 571	58.2(41.7~74.7)	52.2(34.5~70.0)	61.6(44.7~78.5)	5.74	0.017
有	1 198	41.8(25.3~58.3)	47.8(30.0~65.5)	38.4(21.5~55.3)
被动吸烟
无	1 360	43.1(19.8~66.3)	33.9(12.3~55.5)	48.3(22.6~74.0)	6.42	0.011
有	1 409	56.9(33.7~80.2)	66.1(44.5~87.7)	51.7(26.0~77.4)
室内空气污染
否	1 502	50.3(7.9~92.6)	48.4(11.6~85.3)	51.3(5.7~96.9)	0.57	0.449
是	1 267	49.7(7.4~92.1)	51.6(14.7~88.4)	48.7(3.1~94.3)
合计	2 770	100.0		36.3(27.5~45.1)		63.7(54.9~72.5)

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吸烟对慢性阻塞性肺疾病及呼吸道症状的影响

doi: 10.16462/j.cnki.zhjbkz.2020.01.010

通讯作者:
刘志荣, E-mail:lzr@ahcdc.com.cn

叶冬青, E-mail:ydq@ahmu.edu.cn

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Effects of smoking on chronic obstructive pulmonary disease and respiratory symptoms

Corresponding author: LIU Zhi-rong, E-mail:lzr@ahcdc.com.cn; YE Dong-qing, E-mail:ydq@ahmu.edu.cn

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吸烟对慢性阻塞性肺疾病及呼吸道症状的影响

doi: 10.16462/j.cnki.zhjbkz.2020.01.010

通讯作者: 刘志荣, E-mail:lzr@ahcdc.com.cn 叶冬青, E-mail:ydq@ahmu.edu.cn

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Effects of smoking on chronic obstructive pulmonary disease and respiratory symptoms

Corresponding author: LIU Zhi-rong, E-mail:lzr@ahcdc.com.cn; YE Dong-qing, E-mail:ydq@ahmu.edu.cn

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出版历程

目录

通讯作者:
刘志荣, E-mail:lzr@ahcdc.com.cn

叶冬青, E-mail:ydq@ahmu.edu.cn