江苏省海门市1999-2016年成年女性乳腺癌发病及死亡趋势分析

钱俊华; 王莹莹; 杨艳蕾; 黄培新; 江峰; 王娜; 姜庆五

doi:10.16462/j.cnki.zhjbkz.2020.02.013

江苏省海门市1999-2016年成年女性乳腺癌发病及死亡趋势分析

doi: 10.16462/j.cnki.zhjbkz.2020.02.013

1.
226100 南通, 江苏省海门市疾病预防控制中心
2.
20032 上海, 复旦大学公共卫生学院流行病学教研室公共卫生安全教育部重点实验室

钱俊华和王莹莹为共同第一作者

详细信息

通讯作者:
杨艳蕾, Email:28989298@qq.com

中图分类号: R181.8
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出版历程
- 收稿日期: 2019-08-20
- 修回日期: 2019-11-07
- 刊出日期: 2020-02-10

Analysis on incidence and death trend of breast cancer in adult women from 1999 to 2016 in Haimen, Jiangsu Province

1.
Haimen City Center for Disease Control and Prevention, Nantong 226100, China
2.
Key Laboratory of Public Health Safety of Ministry of Education, Department of Epidemiology, School of Public Health, Fudan University, Shanghai 20032, China

QIAN Jun-hua and WANG Ying-ying contributed equally to this work

More Information

Corresponding author: YANG Yan-lei, Email:28989298@qq.com

摘要

摘要: 目的分析海门市1999-2016年成年女性乳腺癌发病及死亡率情况。方法利用海门市肿瘤登记报告系统中1999-2016年女性乳腺癌患者的发病及死亡资料, 计算粗发病率、粗死亡率、标化率、年龄别率、变化百分比(percent change, PC)和年度变化百分比(annual percentage change, APC)等指标。结果海门市1999-2016年成年女性乳腺癌新发病例2 977人, 粗发病率、中标发病率分别为39.29/10万、20.65/10万; APC分别为5.87%、4.71%。因乳腺癌死亡病例938人, 粗死亡率、中标死亡率分别为12.38/10万、6.07/10万; APC分别为3.87%、2.43%。乳腺癌年龄别发病率随年龄递增, 30~岁发病迅速攀升, 发病高峰出现在55~岁(65.05/10万)及70~岁(60.77/10万); 乳腺癌年龄别死亡率随年龄呈缓慢递增, 直至80岁出现死亡高峰(29.68/10万)。结论海门市乳腺癌发病率和死亡率总体呈现逐年上升趋势, 且随年龄增长而递增。世标发病率及世标死亡率均高于全省及全国水平。应加强本地区乳腺癌的防治工作。
- 乳腺癌 /
- 发病率 /
- 死亡率
Abstract: Objective To analyze the incidence and mortality of female breast cancer from 1999 to 2016 in Haimen City. Methods Data of female breast cancer from 1999 to 2016 in the Haimen Tumor Registry Reporting System were used to calculate the crude incidence and mortality, standardized incidence and mortality, age-specific incidence and mortality, percentage change of rate(PC) and annual percentage change of rate(APC). Results There were 2 977 cases from 1999 to 2016. The crude incidence and age-standardized incidence by Chinese standard population were 39.29/100 000 and 20.65/100 000, respectively; APC were 5.87% and 4.71%, respectively. There were 938 deaths, the crude mortality and standardized mortality by Chinese standard population were 12.38/100 000 and 6.07/100 000, respectively; APC were 3.87% and 2.43%, respectively. The incidence increased with age, with a sharp increase occuring in 30-years old and two peaks occuring in 55-years old(65.05/100 000) and 70-years old(60.77/100 000). The mortality gradually increased with age and the peak was at age 80(29.68/100 000). Conclusion The incidence and mortality of female breast cancer in Haimen City had a upward trend with year and age. The age-standardized incidence and mortality by world standard population were higher than provincial and national levels. The work for prevention and control of female breast cancer in this region should be strengthened.
- Breast cancer /
- Incidence /
- Mortality

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图 1 海门市1999-2016年成年女性乳腺癌发病趋势

Figure 1. The incidence trend of female breast cancer from 1999 to 2016 in Haimen City

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图 2 海门市1999-2016年成年女性乳腺癌死亡趋势

Figure 2. The mortality trend of female breast cancer from 1999 to 2016 in Haimen City

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图 3 海门市1999-2016年成年女性乳腺癌年龄别发病及死亡趋势

Figure 3. The age-specific incidence and mortality trend of female breast cancer from 1999 to 2016 in Haimen City

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表 1 海门市1999-2016年成年女性乳腺癌发病率及死亡率

Table 1. The incidence and mortality of female breast cancer from 1999 to 2016 in Haimen City

年份	平均人口数^a(人)	发病情况				死亡情况
年份	平均人口数^a(人)	发病数(人)	粗发病率(/10万)	中标发病率(/10万)	世标发病率(/10万)	死亡数(人)	粗死亡率(/10万)	中标死亡率(/10万)	世标死亡率(/10万)
1999	410 996	95	23.11	13.36	21.03	33	8.03	4.16	6.43
2000	410 704	105	25.57	14.60	22.33	35	8.52	4.50	6.62
2001	412 795	110	26.65	15.22	23.34	51	12.35	6.69	10.89
2002	414 758	99	23.87	13.65	20.83	42	10.13	5.74	8.97
2003	416 550	111	26.65	15.20	23.61	36	8.64	4.55	7.31
2004	418 379	144	34.42	18.71	29.63	41	9.80	5.10	7.78
2005	420 178	126	29.99	16.34	25.27	57	13.57	7.23	11.21
2006	421 839	135	32.00	16.53	25.65	40	9.48	5.19	8.01
2007	423 524	164	38.72	20.94	32.93	56	13.22	6.13	9.71
2008	425 071	171	40.23	21.82	33.43	48	11.29	5.54	8.69
2009	426 510	153	35.87	17.67	27.83	47	11.02	5.69	8.39
2010	427 848	221	51.65	27.48	42.47	58	13.56	6.22	9.98
2011	426 799	212	49.67	23.68	38.12	61	14.29	6.67	10.43
2012	425 860	207	48.61	24.98	39.18	69	16.20	6.97	11.07
2013	424 936	226	53.18	26.77	41.86	67	15.77	7.34	11.51
2014	424 038	229	54.00	27.17	42.37	58	13.68	6.36	10.03
2015	423 243	222	52.45	25.96	40.86	63	14.89	6.81	10.75
2016	423 726	247	58.29	27.58	44.19	76	17.94	7.51	12.12
合计	7 577 754	2 977	39.29	20.65	32.40	938	12.38	6.07	9.52
PC(%)	-	-	127.49	91.49	96.15	-	98.37	65.36	75.25
APC(%)	-	-	5.87	4.71	4.92	-	3.87	2.43	2.63
T值	-	-	14.229	10.432	10.791	-	6.280	4.187	4.063
P值	-	-	< 0.001	< 0.001	< 0.001	-	< 0.001	0.001	0.001
注:^a每年的平均人口数为20岁及以上女性人数。

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表 2 海门市1999-2016年成年女性乳腺癌年龄别发病率及死亡率

Table 2. The age-specific incidence and mortality of female breast cancer from 1999 to 2016 in Haimen City

年龄(岁)	平均人口数(人)	发病情况		死亡情况
年龄(岁)	平均人口数(人)	发病数(人)	发病率(/10万)	发病数(人)	发病率(/10万)
20~	495 219	8	1.62	1	0.20
25~	519 908	17	3.27	1	0.19
30~	686 098	61	8.89	18	2.62
35~	755 198	151	19.99	47	6.22
40~	871 186	326	37.42	84	9.64
45~	856 341	468	54.65	114	13.31
50~	717 096	418	58.29	105	14.64
55~	667 213	434	65.05	116	17.39
60~	534 718	333	62.28	98	18.33
65~	426 074	241	56.56	88	20.65
70~	360 364	219	60.77	84	23.31
75~	305 595	148	48.43	82	26.83
80~	215 631	106	49.16	64	29.68
≥85	167 113	47	28.12	36	21.54
合计	7 577 754	2977	39.29	938	12.38

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参考文献(14)

[1]	Siegel R, Ma J, Zou Z, et al. Cancer Statistics, 2014[J]. CA Cancer J Clin, 2014, 64(1): 9-29. DOI: 10.3322/caac.21208.
[2]	Naghavi M, Wang HD, Lozano R, et al. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013[J]. Lancet, 2015, 385(9963): 117-171. DOI: 10.1016/S0140-6736(14)61682-2.
[3]	王乐, 张玥, 石菊芳, 等.中国女性乳腺癌疾病负担分析[J].中华流行病学杂志, 2016, 37(7): 970-976. DOI: 10.3760/cma.j.issn.0254-6450.2016.07.013. Wang L, Zhang Y, Shi JF, et al. Disease burden of famale breast cancer in China[J]. Chin J Epidemiol, 2016, 37(7): 970-976. DOI: 10.3760/cma.j.issn.0254-6450.2016.07.013.
[4]	国家卫生健康委. 2018中国卫生健康统计年鉴[M].北京: 中国协和医科大学出版社, 2018. National Health Commission. 2018 China Health Statistical Digest[M]. Beijing: Beijing Union Medical University Press, 2018.
[5]	项永兵, 张薇, 高立峰, 等.恶性肿瘤发病率的时间趋势分析方法[J].中华流行病学杂志, 2004, 25(2): 173-177. DOI: 10.3760/j.issn:0254-6450.2004.02.022. Xiang YB, Zhang W, Gao LF, et al. Methods for time trend analysis of cancer incidence rates[J]. Chin J Epidemiol, 2004, 25(2): 173-177. DOI: 10.3760/j.issn:0254-6450.2004.02.022.
[6]	孙可欣, 郑荣寿, 顾秀瑛, 等. 2000-2014年中国肿瘤登记地区女性乳腺癌发病趋势及年龄变化情况分析[J].中华预防医学杂志, 2018, 52(6): 567-572. DOI: 10.3760/cma.j.issn.0253-9624.2018.06.003. Sun KX, Zheng RS, Gu XY, et al. Incidence trend and change in the age distribution of female breast cancer in cancer registration areas of China from 2000 to 2014[J]. Chin J Prevent Med, 2018, 52(6): 567-572. DOI: 10.3760/cma.j.issn.0253-9624.2018.06.003.
[7]	韩仁强, 武鸣, 罗鹏飞, 等. 2014年江苏省恶性肿瘤发病和死亡分析[J].肿瘤预防与治疗, 2018, 31(1): 24-31. DOI: 10.3969/j.issn.1674-0904.2018.01.005. Han RQ, Wu M, Luo PF, et al. Cancer Incidence and Mortality in Jiangsu Province[J]. J Cancer Control Treat, 2018, 31(1): 24-31. DOI: 10.3969/j.issn.1674-0904.2018.01.005.
[8]	张敏璐, 彭鹏, 吴春晓, 等. 2008-2012年中国肿瘤登记地区女性乳腺癌发病和死亡分析[J].中华肿瘤杂志, 2019, 41(4): 315-320. DOI: 10.3760/cma.j.issn.0253-3766.2019.04.013. Zhang ML, Peng P, Wu CX, et al. Report of breast cancer incidence and mortality in China registry regions[J]. Chin J Oncol, 2019, 41(4): 315-320. DOI: 10.3760/cma.j.issn.0253-3766.2019.04.013.
[9]	徐燕, 黄玉华, 史爱玉, 等.上海市崇明县1998-2013年女性乳腺癌发病率和死亡率趋势分析[J].上海预防医学, 2017, 29(2): 105-108. DOI: 10.3969/j.issn.1004-9231.2017.02.005. Xu Y, Huang YH, Shi AY, et al. Analysis on the trend for the morbidity and mortality of female breast cancer in Chongming County of Shanghai from 1998 to 2013[J]. Shanghai J Prevent Med, 2017, 29(2): 105-108. DOI: 10.3969/j.issn.1004-9231.2017.02.005.
[10]	陈万青, 郑荣寿.中国女性乳腺癌发病死亡和生存状况[J].中国肿瘤临床, 2015, 42(13): 668-674. DOI: 10.3969/j.issn.1000-8179.20150571. Chen WQ, Zheng RS. Incidence, mortality and survival analysis of breast cancer in China[J]. Chin J Clin Oncol, 2015, 42(13): 668-674. DOI: 10.3969/j.issn.1000-8179.20150571.
[11]	Hartmann LC, Radisky DC, Frost MH, et al. Understanding the Premalignant Potential of Atypical Hyperplasia through Its Natural History: A Longitudinal Cohort Study[J]. Cancer Prev Res(Phila), 2014, 7(2): 211-217. DOI: 10.1158/1940-6207.CAPR-13-0222.
[12]	倪倬健, 王寒松, 陈燕熙. 1989年-2008年海门市女性乳腺癌死亡趋势分析[J].江苏预防医学, 2009, 20(4): 1-3. DOI: 10.3969/j.issn.1006-9070.2009.04.001. Ni ZJ, Wang HS, Chen YX. The trend analysis of mortality with female breast cancer during 1989-2008, Haimen city[J]. Jiangsu J Prev Med, 2009, 20(4): 1-3. DOI: 10.3969/j.issn.1006-9070.2009.04.001.
[13]	周薇, 张志将, 毕勇毅, 等.中国女性1987-2014年乳腺癌死亡趋势的Joinpoint回归分析[J].中南大学学报(医学版), 2018, 43(2): 210-215. DOI: 10.11817/j.issn.1672-7347.2018.02.018. Zhou W, Zhang ZJ, Bi YY, et al. Joinpoint regression analysis for the mortality trend of breast cancer in Chinese female from 1987 to 2014[J]. J Central South Univ(Med Ed), 2018, 43(2): 210-215. DOI: 10.11817/j.issn.1672-7347.2018.02.018.
[14]	何明艳, 朱碧琪, 钟媛, 等. 2005-2013年中国女性乳腺癌发病及死亡趋势分析[J].中华疾病控制杂志, 2019, 23(1): 10-14. DOI: 10.16462/j.cnki.zhjbkz.2019.01.003. He MY, Zhu BQ, Zhong Y, et al. Analysis of the incidence and mortality trend of breast cancer in Chinese women from 2005 to 2013[J]. Chin J Dis Control Prev, 2019, 23(1): 10-14. DOI: 10.16462/j.cnki.zhjbkz.2019.01.003.