全球乙型肝炎病毒基因型的分布现状

吴明山; 刘振球; 陈兴栋; 张铁军

doi:10.16462/j.cnki.zhjbkz.2020.02.018

全球乙型肝炎病毒基因型的分布现状

doi: 10.16462/j.cnki.zhjbkz.2020.02.018

200032 上海, 复旦大学公共卫生学院流行病学教研室复旦大学公共卫生安全教育部重点实验室

基金项目: 国家自然科学基金(81772170)

详细信息

通讯作者:
张铁军, E-mail:tjzhang@shmu.edu.cn

中图分类号: R735.7
计量
- 文章访问数: 1150
- HTML全文浏览量: 571
- PDF下载量: 298
- 被引次数: 0
出版历程
- 收稿日期: 2019-09-19
- 修回日期: 2019-12-15
- 刊出日期: 2020-02-10

Current situation on the global distribution of hepatitis B virus subtypes

Department of Epidemiology, School of Public Health, Fudan University, Ministry of Education Key Laboratory of Safety, Shanghai 200032, China

Funds: National Natural Science Foundation of China(81772170)

More Information

Corresponding author: ZHANG Tie-jun, E-mail:tjzhang@shmu.edu.cn

摘要

摘要: 乙型肝炎病毒(hepatitis B virus, HBV)感染是全球范围内一个重要的公共卫生问题, 是慢性肝炎、肝硬化及肝癌发生的主要原因。许多研究表明, HBV不同的基因型及其亚型, 其致病性存在差异, 从而影响感染者的疾病进程和治疗预后。迄今为止, 全球已经报道了10种HBV基因型及40多种HBV亚型, 这些亚型有其各自的分布特征, 本文对全球乙型肝炎病毒基因型的分布现状进行综述。
- 乙型肝炎病毒 /
- 基因型 /
- 分布
Abstract: Hepatitis B virus(HBV) infection is an important global public health concern and a major cause of chronic hepatitis, cirrhosis and liver cancer. Many studies have shown that different genotypes and subtypes have significant differences in pathogenicity, thus affecting the disease progression and prognosis of infected individuals. So far, a total of 10 HBV genotypes and more than 40 subtypes have been reported across the world, and these subtypes have shown distinct distribution characteristics. In the present review, we systematically summarized the current situation on the global distribution of HBV genotypes.
- Hepatitis B virus /
- Genotype /
- Distribution

HTML全文

表 1 不同基因型的地区分布

Table 1. Regional distribution of different genotypes

基因型	亚型	地区分布
A	A1	撒哈拉以南的非洲、亚洲
	A2	北欧、美国、日本
	A3~A7	西非
B	B1	日本
	B2~B5	东亚、中国、印尼、越南、菲律宾
	B6	阿拉斯加、加拿大北部、格陵兰
	B7~B9	印度尼西亚
C	C1~C3	中国、韩国、东南亚、泰国
	C4	澳大利亚
	C5~C16	菲律宾、越南、印度尼西亚
D	D1	中东、北非
	D2~D5	土耳其、黎巴嫩、塞尔维亚、巴西、南亚、肯尼亚、卢旺达
	D6~D10	欧洲、印度尼西亚、摩洛哥、突尼斯、印度
E	-	西非
F	F1~F4	中南美洲
G	-	法国、德国、美国
H	-	墨西哥、中美洲
I	-	越南、老挝及我国的云南
J	-	日本

下载: 导出CSV

参考文献(49)

[1]	World Health Organization. Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection[M]. Geneva: World Health Organization, 2015.
[2]	Velkov S, Ott JJ, Protzer U, et al. The global hepatitis B virus genotype distribution approximated from available genotyping data[J]. Genes(Basel), 2018, 9(10): E495. DOI: 10.3390/genes9100495.
[3]	Schweitzer A, Horn J, Mikolajczyk RT, et al. Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013[J]. Lancet, 2015, 386(10003): 1546-1555. DOI: 10.1016/s0140-6736(15)61412-x.
[4]	Norder H, Courouce AM, Coursaget P, et al. Genetic diversity of hepatitis B virus strains derived worldwide: genotypes, subgenotypes, and HBsAg subtypes[J]. Intervirology. 2004, 47(6): 289-309. DOI: 10.1159/000080872.
[5]	Kramvis A. Genotypes and genetic variability of hepatitis B virus[J]. Intervirology, 2014, 57(3-4): 141-150. DOI: 10.1159/000360947.
[6]	Sousa DD, Silva CRS, Lima Junior WP, et al. Phylogenetic analysis and genotype distribution of hepatitis B virus(HBV)in Roraima, Brazil[J]. Rev Inst Med Trop Sao Paulo, 2018, 60: e35. DOI: 10.1590/S1678-9946201860035.
[7]	Sagnelli C, Ciccozzi M, Alessio L, et al. HBV molecular epidemiology and clinical condition of immigrants living in Italy[J]. Infection, 2018, 46(4): 523-531. DOI: 10.1007/s15010-018-1153-1.
[8]	Okamoto H, Tsuda F, Sakugawa H, et al. Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes[J]. J Gen Virol, 1988, 69(Pt 10): 2575-2583. DOI: 10.1099/0022-1317-69-10-2575.
[9]	Norder H, Courouce AM, Magnius LO. Complete genomes, phylogenetic relatedness, and structural proteins of six strains of the hepatitis B virus, four of which represent two new genotypes[J]. Virology, 1994, 198(2): 489-503. DOI: 10.1006/viro.1994.1060.
[10]	Stuyver L, De Gendt S, Van Geyt C, et al. A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness[J]. J Gen Virol, 2000, 81(Pt 1): 67-74. DOI: 10.1099/0022-1317-81-1-67.
[11]	Arauz-Ruiz P, Norder H, Robertson BH, et al. Genotype H: a new amerindian genotype of hepatitis B virus revealed in central America[J]. J Gen Virol, 2002, 83(Pt 8): 2059-2073. DOI: 10.1099/0022-1317-83-8-2059.
[12]	Tran TT, Trinh TN, Abe K. New complex recombinant genotype of hepatitis B virus identified in Vietnam[J]. J Virol, 2008, 82(11): 5657-5663. DOI: 10.1128/JVI.02556-07.
[13]	Tatematsu K, Tanaka Y, Kurbanov F, et al. A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype J[J]. J Virol, 2009, 83(20): 10538-10547. DOI: 10.1128/jvi.00462-09.
[14]	Hubschen JM, Mbah PO, Forbi JC, et al. Detection of a new subgenotype of hepatitis B virus genotype A in cameroon but not in neighbouring nigeria[J]. Clin Microbiol Infect, 2011, 17(1): 88-94. DOI: 10.1111/j.1469-0691.2010.03205.x.
[15]	Thedja MD, Muljono DH, Nurainy N, et al. Ethnogeographical structure of hepatitis B virus genotype distribution in indonesia and discovery of a new subgenotype, B9[J]. Arch Virol, 2011, 156(5): 855-868. DOI: 10.1007/s00705-011-0926-y.
[16]	Mulyanto, Pancawardani P, Depamede SN, et al. Identification of four novel subgenotypes(C13-C16)and two inter-genotypic recombinants(C12/G and C13/B3)of hepatitis B virus in Papua province, Indonesia[J]. Virus Res, 2012, 163(1): 129-140. DOI: 10.1016/j.virusres.2011.09.002.
[17]	Hundie GB, Stalin Raj V, Gebre Michael D, et al. A novel hepatitis B virus subgenotype D10 circulating in Ethiopia[J]. J Viral Hepat, 2017, 24(2): 163-173. DOI: 10.1111/jvh.12631.
[18]	Mojsiejczuk LN, Torres C, Fainboin HA, et al. Identification of a new clade of hepatitis B virus genotype F[J]. Infect Genet Evol, 2015, 34: 122-125. DOI: 10.1016/j.meegid.2015.06.007.
[19]	Kramvis A, Kew MC. Epidemiology of hepatitis B virus in Africa, its genotypes and clinical associations of genotypes[J]. Hepatol Res, 2007, 37(S1): S9-S19. DOI: 10.1111/j.1872-034X.2007.00098.x.
[20]	Lin SYC, Magalis BR, Salemi M, et al. Origin and dissemination of hepatitis B virus genotype C in east Asia revealed by phylodynamic analysis and historical correlates[J]. J Viral Hepat, 2019, 26(1): 145-154. DOI: 10.1111/jvh.13006.
[21]	Qian Z, Jianqiong W, Hongmei L, et al. Distribution and epidemiologic trends of HBV genotypes and subtypes in 14 countries neighboring China[J]. Hepatitis Monthly, 2015, 15(5): e24422. DOI: 10.5812/hepatmon.15(5)2015.24422.
[22]	Mahmood M, Anwar MA, Khanum A, et al. Distribution and clinical significance of hepatitis B virus genotypes in Pakistan[J]. BMC Gastroenterol, 2016, 16: 104. DOI: 10.1186/s12876-016-0513-5.
[23]	Asaad AM, Al-Ayed MS, Aleraky M, et al. Hepatitis B virus genotyping in chronic hepatitis B patients in southwestern Saudi Arabia[J]. Braz J Infect Dis, 2015, 19(5): 525-528. DOI: 10.1016/j.bjid.2015.03.007.
[24]	Ghany MG, Perrillo R, Li R, et al. Characteristics of adults in the hepatitis B research network in north America reflect their country of origin and hepatitis B virus genotype[J]. Clin Gastroenterol Hepatol, 2015, 13(1): 183-192. DOI: 10.1016/j.cgh.2014.06.028.
[25]	Lampe E, Mello FCA, do Espirito-Santo MP, et al. Nationwide overview of the distribution of hepatitis B virus genotypes in Brazil: a 1000-sample multicentre study[J]. J Gen Virol, 2017, 98(6): 1389-1398. DOI: 10.1099/jgv.0.000789.
[26]	Roman S, Jose-Abrego A, Fierro NA, et al. Hepatitis B virus infection in Latin America: A genomic medicine approach[J]. World J Gastroenterol, 2014, 20(23): 7181-7196. DOI: 10.3748/wjg.v20.i23.7181.
[27]	Li HM, Wang JQ, Wang R, et al. Hepatitis B virus genotypes and genome characteristics in China[J]. World J Gastroenterol. 2015, 21(21): 6684-6697. DOI: 10.3748/wjg.v21.i21.6684.
[28]	陈仁, 廖金瑶, 罗晓丹, 等.慢性乙肝患者HBsAg水平与HBV-DNA相关性研究[J].中华疾病控制杂志, 2016, 20(8): 856-859. DOI: 10.16462/j.cnki.zhjbkz.2016.08.025. Chen R, Liao JY, Luo XD, et al. Study on the relationship of the HBsAg levels and HBV-DNA in the chronic hepatitis B patients[J]. Chin J Dis Control Prev, 2016, 20(8): 856-859. DOI: 10.16462/j.cnki.zhjbkz.2016.08.025.
[29]	孙国栋, 王安辉, 王宇飞, 等.武威市某社区人群HBsAg携带者自发性再激活的流行病学特征[J].中华疾病控制杂志, 2017, 21(4): 332-335. DOI: 10.16462./j.cnki.zhjbkz.2017.04.003. Sun GD, Wang AH, Wang YF, et al. Epidemiological characteristics of the spontaneous reactivation of HBV carriers in community population in WuweiCity[J]. Chin J Dis Control Prev, 2017, 21(4): 332-335. DOI: 10.16462./j.cnki.zhjbkz.2017.04.003.
[30]	Wei DH, Liu HZ, Huang AM, et al. A new trend of genotype distribution of hepatitis B virus infection in southeast China(Fujian), 2006-2013[J]. Epidemiol Infect, 2015, 143(13): 2822-2826. DOI: 10.1017/S0950268815000059.
[31]	Ito K, Yotsuyanagi H, Sugiyama M, et al. Geographic distribution and characteristics of genotype A hepatitis B virus infection in acute and chronic hepatitis B patients in Japan[J]. J Gastroenterol Hepatol, 2016, 31(1): 180-189. DOI: 10.1111/jgh.13030.
[32]	Shen L, Yin W, Zheng H, et al. Molecular epidemiological study of hepatitis B virus genotypes in southwest, China[J]. J Med Virol, 2014, 86(8): 1307-1313. DOI: 10.1002/jmv.23965.
[33]	Bissinger AL, Fehrle C, Werner CR, et al. Epidemiology and genotyping of patients with chronic hepatitis B: genotype shifting observed in patients from central Europe[J]. Pol J Microbiol, 2015, 64(1): 15-21. http://smartsearch.nstl.gov.cn/paper_detail.html?id=35a742045665d8016ffcbfb62583a753
[34]	Malagnino V, Salpini R, Maffongelli G, et al. High rates of chronic HBV genotype E infection in a group of migrants in Italy from west Africa: Virological characteristics associated with poor immune clearance[J]. PLoS One, 2018, 13(3): e0195045. DOI: 10.1371/journal.pone.0195045.
[35]	Panduro A, Maldonado-Gonzalez M, Fierro NA, et al. Distribution of HBV genotypes F and H in Mexico and central America[J]. Antivir Ther, 2013, 18(3 Pt B): 475-484. DOI: 10.3851/IMP2605.
[36]	Zhang Q, Liao Y, Chen J, et al. Epidemiology study of HBV genotypes and antiviral drug resistance in multi-ethnic regions from western China[J]. Sci Rep, 2015, 5: 17413. DOI: 10.1038/srep17413.
[37]	Datta S, Roychoudhury S, Ghosh A, et al. Distinct distribution pattern of hepatitis B virus genotype C and D in liver tissue and serum of dual genotype infected liver cirrhosis and hepatocellular carcinoma patients[J]. PLoS One, 2014, 9(7): e102573. DOI: 10.1371/journal.pone.0102573.
[38]	Lin CL, Kao JH. Natural history of acute and chronic hepatitis B: the role of HBV genotypes and mutants[J]. Best Pract Res Clin Gastroenterol, 2017, 31(3): 249-255. DOI: 10.1016/j.bpg.2017.04.010.
[39]	Osiowy C, Giles E, Trubnikov M, et al. Characterization of acute and chronic hepatitis B virus genotypes in Canada[J]. PLoS One, 2015, 10(9): e0136074. DOI: 10.1371/journal.pone.0136074.
[40]	Pezzano SC, Torres C, Fainboim HA, et al. Hepatitis B virus in buenos aires, argentina: genotypes, virological characteristics and clinical outcomes[J]. Clin Microbiol Infect, 2011, 17(2): 223-231. DOI: 10.1111/j.1469-0691.2010.03283.x.
[41]	Sarkar N, Pal A, Das D, et al. Virological characteristics of acute hepatitis B in eastern India: critical differences with chronic infection[J]. PLoS One, 2015, 10(11): e0141741. DOI: 10.1371/journal.pone.0141741.
[42]	Chen BF, Liu CJ, Jow GM, et al. Evolution of hepatitis B virus in an acute hepatitis B patient co-infected with genotypes B and C[J]. J Gen Virol, 2006, 87(Pt 1): 39-49. DOI: 10.1099/vir.0.81357-0.
[43]	Liao H, Li X, Liu Y, et al. Intergenotype recombinant analysis of full-length hepatitis B virus genomes from 516 chinese patients with different illness categories[J]. J Med Virol, 2017, 89(1): 139-145. DOI: 10.1002/jmv.24609.
[44]	Yang J, Chen X, Zhang H, et al. HBV genotype C strains with spontaneous ymdd mutations may be a risk factor for hepatocellular carcinoma[J]. J Med Virol, 2014, 86(6): 913-917. DOI: 10.1002/jmv.23895.
[45]	Wong GL, Chan HL, Yiu KK, et al. Meta-analysis: the association of hepatitis B virus genotypes and hepatocellular carcinoma[J]. Aliment Pharmacol Ther, 2013, 37(5): 517-526. DOI: 10.1111/apt.12207.
[46]	Ching LK, Gounder PP, Bulkow L, et al. Incidence of hepatocellular carcinoma according to hepatitis B virus genotype in Alaska native people[J]. Liver Int, 2016, 36(10): 1507-1515. DOI: 10.1111/liv.13129.
[47]	Wen J, Song C, Jiang D, et al. Hepatitis B virus genotype, mutations, human leukocyte antigen polymorphisms and their interactions in hepatocellular carcinoma: A multi-centre case-control study[J]. Sci Rep, 2015, 5: 16489. DOI: 10.1038/srep16489.
[48]	Tseng TC, Liu CJ, Hsu CY, et al. High level of hepatitis B core-related antigen associated with increased risk of hepatocellular carcinoma in patients with chronic HBV infection of intermediate viral load[J]. Gastroenterology, 2019, 157(6): 1518-1529. DOI: 10.1053/j.gastro.2019.08.028.
[49]	Atsama Amougou M, Marchio A, Bivigou-Mboumba B, et al. Enrichment in selected genotypes, basal core and precore mutations of hepatitis B virus in patients with hepatocellular carcinoma in Cameroon[J]. J Viral Hepat, 2019, 26(9): 1086-1093. DOI: 10.1111/jvh.13131.