2015-2018年淄博市肾综合征出血热流行特征和宿主动物监测

王玲; 张艳; 张玲; 刘芳盈; 孙涛; 姜晓林; 王志强; 王显军

doi:10.16462/j.cnki.zhjbkz.2020.02.022

2015-2018年淄博市肾综合征出血热流行特征和宿主动物监测

doi: 10.16462/j.cnki.zhjbkz.2020.02.022

王玲¹,
张艳¹,
张玲¹,
刘芳盈¹,
孙涛¹,
姜晓林²,
王志强²,
王显军^2, ,

1.
255026 淄博, 淄博市疾病预防控制中心
2.
250014 济南, 山东省疾病预防控制中心

基金项目: 国家科技重大专项(2017ZX10104001-005-001)

详细信息

通讯作者:
王显军, E-mail:xjwang62@163.com

中图分类号: R512.8
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- 被引次数: 0
出版历程
- 收稿日期: 2019-07-23
- 修回日期: 2019-12-15
- 刊出日期: 2020-02-10

Analysis of epidemiological characteristics and surveillance result of host animal on hemorrhagic fever with renal syndrome in Zibo City from 2015 to 2018

1.
Center for Disease Control and Prevention, Zibo 250026, China
2.
Shandong Center for Disease Control and Prevention, Jinan 250014, China

Funds: National Science and Technology Major Project(2017ZX10104001-005-001)

More Information

Corresponding author: WANG Xian-jun, E-mail:xjwang62@163.com

摘要

摘要: 目的分析淄博市2015-2018年肾综合征出血热(hemorrhagic fever with renal syndrome, HFRS)的流行特征、宿主分布及其携带病毒的情况, 为防控工作提供依据。方法运用描述性流行病学方法对全市疫情资料和宿主动物监测数据进行统计分析。结果 2015-2018年全市报告肾综合征出血热315例, 死亡1例, 平均发病率为1.69/10万, 病死率0.32%。病例主要集中在淄川区和沂源县, 占全市总病例数的67.62%。以中老年农民为主, 45~69岁年龄组占总病例数的62.86%。发病时间主要集中在3-5月和10-12月。全市平均鼠密度为3.04%, 鼠带病毒率为3.87%, 居民区以褐家鼠为优势鼠种, 野外以黑线姬鼠为优势鼠种, 褐家鼠和黑线姬鼠带毒率分别为6.48%和0.75%, 两种鼠带毒率差异有统计学意义(χ²=6.694, P=0.01)。结论淄博市HFRS发病呈下降趋势, 但疫情高发区(县)的鼠密度和鼠带病毒率维持在较高水平, 存在HFRS爆发流行的风险, 应继续加强重点地区的疫苗接种, 落实防鼠灭鼠及健康教育等综合措施。
- 肾综合征出血热 /
- 流行特征 /
- 监测
Abstract: Objective To analyze the epidemic characteristics of hemorrhagic fever with renal syndrome(HFRS), the distribution and virus-carrying status of host animals in Zibo City from 2015 to 2018, so as to provide references for prevention and control. Methods Descriptive epidemiological study was conducted on the incidence data of HFRS collected in Zibo City from 2015 to 2018. Results A total of 315 cases including one death were reported in Zibo, with the average incidence of 1.69/100000 and the fatality rate of 0.32%. The cases were distributed mainly in Zichuan District and Yiyuan Coutry, which accounting for 67.62%. The main groups of cases were middle-aged and elderly farmers, and people aged 45-69 accounted for 62.86% of total cases. Two peak seasons were observed in spring(March-May) and autumn-winter(October-December). The average rat density and virus-carrying rate were 3.04% and 3.87% respectively rattus norvegicus was the dominant species of rodents in the residential area, while in the field, apodemus agrarius was the dominant species.The virus-carrying rates of rattus norvegicus and apodemus agrarius were 6.48% and 0.75% respectively, which had significant difference in these two group(χ²=6.694, P=0.01). Conclusions The incidence rate of HFRS was declining in Zibo City, while the rat density and the virus-carrying rate were still high in the areas with high incidence, which indicating the outbreak risk of HFRS was existed.It is necessary to strengthen immunization, rodent control and health education in high-endemic areas.
- Hemorrhagic fever with renal syndrome /
- Epidemic characteristics /
- Monitor

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图 1 淄博市2015-2018年HFRS地区分布

Figure 1. Spatial distribution of HRFS in Zibo, 2015-2018

下载: 全尺寸图片幻灯片

图 2 淄博市2015年-2018年HFRS时间分布

Figure 2. Monthy distribution of HFRS in Zibo, 2015-2018

下载: 全尺寸图片幻灯片

图 3 淄博市部分汉坦病毒株L片段的系统发育树

Figure 3. Phylogenetic tree based on the L segments of Hantaan virus from todents in Zibo City

下载: 全尺寸图片幻灯片

表 1 2015-2018年淄博市HFRS发病情况

Table 1. Incidence of HFRS in Zibo, 2015-2018

年份	发病数(例)	发病率(/10万)	死亡数	病死率(%)
2015	84	1.82	1	1.19
2016	65	1.40	0	0.00
2017	93	1.98	0	0.00
2018	73	1.55	0	0.00
合计	315	1.69	1	0.32

下载: 导出CSV

表 2 淄博2015-2018年鼠密度及构成

Table 2. Density and species composition of rodents in Zibo, 2015-2018

年份	居民区									野外
年份	布夹数	捕鼠数	鼠密度(%)	褐家鼠	小家鼠	黑线姬鼠	鼩鼱	社鼠	大仓鼠	布夹数	捕鼠数	鼠密度(%)	黑线姬鼠	褐家鼠	小家鼠	田鼠	鼩鼱	社鼠	黑线仓鼠	大仓鼠
2015	1 305	95	7.28	92	0	0	1	2	0	848	34	4.01	27	4	1	1	1	0	0	0
2016	2 065	72	3.49	67	4	0	0	0	1	1 231	54	4.39	32	9	2	0	3	4	1	3
2017	2 015	42	2.08	23	12	0	1	6	0	1 810	38	2.10	29	6	2	0	1	0	0	0
2018	2 731	52	1.90	46	4	2	0	0	0	2 753	62	2.25	46	7	3	0	0	0	1	5
合计	8 116	261	3.22	228	20	2	2	8	1	6 642	188	2.83	134	26	8	1	5	4	2	8

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表 3 淄博市2015-2018年出血热鼠带毒率监测结果

Table 3. The virus-carrying rate of rodents in Zibo, 2015-2018

鼠种类	居民区			野外			合计
鼠种类	标本数	阳性数	阳性率(%)	标本数	阳性数	阳性率(%)	标本数	阳性数	阳性率(%)
褐家鼠	221	15	6.79	26	1	3.85	247	16	6.48
黑线姬鼠	2	0	0.00	132	1	0.76	134	1	0.75
小家鼠	19	0	0.00	8	0	0.00	27	0	0.00
鼩鼱	2	0	0.00	5	0	0.00	7	0	0.00
社鼠	8	0	0.00	4	0	0.00	12	0	0.00
大仓鼠	1	0	0.00	8	0	0.00	9	0	0.00
田鼠	-	-	-	1	0	0.00	1	0	0.00
黑线仓鼠	-	-	-	2	0	0.00	2	0	0.00
合计	253	15	5.93	186	2	1.08	439	17	3.87

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参考文献(8)

[1]	张蓉, 妖苹苹, 徐芳, 等.浙江省2013年肾综合征出血热流行特征及监测分析[J].中国媒介生物学及控制杂志, 2015, 26(1): 37-40. DOI: 10.11853/j.issn.1003.4692.2015.01.009. Zhang R, Yao PP, Xu F, et al. Analysis of epidemiological characteristics and surveillance of hemorrhagic fever with renal syndrome in Zhejiang Province, China, 2013[J]. Chin J Vector Biol & Control, 2015, 26(1): 37-40. DOI: 10.11853/j.issn.1003.4692.2015.01.009.
[2]	Klempa B, Fichet-Calvet E, Lecompte E, et al. Hantavirus in African wood mouse, Guinea[J]. Emerg Infect Dis, 2006, 12(4): 838-840. DOI: 10.3201/eid1205.051487.
[3]	Wang L, Wang T, Cui F, et al. Hemorrhagic fever with renal syndrome, Zibo City, China, 2006-2014[J]. Emerg Infect Dis, 2016, 22(2): 274-276. DOI: 10.3201/eid/2202.151516.
[4]	刘怡芳, 吕杰, 董晓春, 等. 2000-2011年天津市肾综合征出血热流行特征分析[J].疾病监测, 2012, 27(4): 277-279. DOI: 10.3784/j.issn.1003-9961.2012.4.008. Liu YF, Lv J, Dong XC et al. Epidemiology of hemorrhagic fever with renal syndrome in Tianjin, 2000-2011[J]. Disease Surveillance, 2012, 27(4): 277-279. DOI: 10.3784/j.issn.1003-9961.2012.4.008.
[5]	Knust B, Rollin PE. Twenty-year summary of surveillance for human hantavirus infections, United States[J]. Emerg Infect Dis, 2013, 19(12): 1934-1937. DOI: 10.3201/eid1912.131217.
[6]	田丽丽, 黎新宇, 张秀春. 2005-2011年北京市肾综合征出血热病例的流行特征[J].中华疾病控制杂志, 2013, 17(5): 407-409. http://www.cqvip.com/QK/80677A/20135/45805957.html Tian LL, Li XY, Zhang XC, et al. Epidemiologic features analysis of hemorrhagic fever with renal syndrome in Beijing City from 2005 to 2011[J]. Chin J Dis Control Prev, 2013, 17(5): 407-409. http://www.cqvip.com/QK/80677A/20135/45805957.html
[7]	白晶晶, 王晓南, 刘力, 等. 2001-2015年湖北省肾综合征出血热流行病学特征分析[J].现代预防医学, 2016, 43(20): 3655-3660. http://d.wanfangdata.com.cn/Periodical/xdyfyx201620003 Bai JJ, Wang XN, Liu L, et al. Analysis on epidemiological characteristics of hemorrhagic fever with renal syndrome in Hubei, China during 2001-2015[J]. Modern Preventive Medicine, 2016, 43(20): 3655-3660. http://d.wanfangdata.com.cn/Periodical/xdyfyx201620003
[8]	郑媛, 周步宇, 朱妮, 等.陕西省2006-2017年肾综合征出血热流行特征及疫苗接种策略探讨[J].中华疾病控制杂志, 2018, 22(10): 1073-1075. DOI: 10.16462/j.cnki.zhjbkz.2018.10.022. Zheng Y, Zhou BY, Zhu N, et al. Epidemiological characteristics and the strategy of vaccination on hemorrhagic fever with renal syndrome in Shaanxi Province, from 2006 to 2017[J]. Chin J Dis Control Prev, 2018, 22(10): 1073-1075. DOI: 10.16462/j.cnki.zhjbkz.2018.10.022.