血清中铜、锌、镍、镉、锰等微量元素对稽留流产影响的研究

谢利傲; 姚鉴玲; 朱天垣; 艾世伟; 党瑜慧; 李芝兰

doi:10.16462/j.cnki.zhjbkz.2020.04.023

血清中铜、锌、镍、镉、锰等微量元素对稽留流产影响的研究

doi: 10.16462/j.cnki.zhjbkz.2020.04.023

1.
730030 兰州, 兰州大学公共卫生学院
2.
743400 静宁, 静宁县妇幼保健院
3.
730030 兰州, 兰州市妇幼保健院腔镜中心

基金项目: 兰州市人才创新创业项目(2019-RC-38)

详细信息

通讯作者:
李芝兰, E-mail:lizhl@lzu.edu.cn

中图分类号: R714.21
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- 被引次数: 0
出版历程
- 收稿日期: 2019-11-14
- 修回日期: 2020-01-18
- 刊出日期: 2020-04-10

Study on the effect of trace elements such as copper, zinc, nickel, iron and manganese in serum on the missed abortion

1.
School of Public Health, Lanzhou University, Lanzhou 730030, China
2.
Jingning County Maternal and Child Care Hospital, Jingning 743400, China
3.
Cavity mirror Center, Lanzhou Maternity and Child Care Hospital, Lanzhou 730030, China

Funds: Lanzhou Talent Innovation and Entrepreneurship Project(2019-RC-38)

More Information

Corresponding author: LI Zhi-lan, E-mail:lizhl@lzu.edu.cn

摘要

摘要: 目的探讨孕早期血清中汞、锰、镍、铜、锌、砷、镉、铅水平对稽留流产的影响, 为稽留流产病因研究提供线索。方法选取同年龄段、同孕周的稽留流产患者及正常早孕者21对, 检测两组孕妇血清汞、锰、镍、铜、锌、砷、镉、铅水平。采用1:1配比Logistic回归分析模型分析稽留流产可能的影响因素。结果与正常早孕组相比, 稽留流产组血清镍(t=3.57, P=0.002)、铜(t=7.94, P < 0.001)、锌(t=3.60, P=0.002)、镉(t=4.74, P < 0.001)、砷(t=2.82, P=0.011)、铅(t=3.46, P=0.002)水平较高, 血清锰水平较低(t=-8.24, P < 0.001);二元多因素Logistic回归分析模型分析结果显示, 高血镍(OR=7.83, 95% CI:1.03~59.68, P=0.037)、高血镉(OR=3.51, 95% CI:2.53~4.87, P=0.004)为稽留流产的危险因素, 高血锰(OR=0.68, 95% CI:0.41~0.97, P=0.030)为保护性因素。结论孕妇血清中镍、镉、锰水平对稽留流产的发生有一定的影响, 其机理有待于进一步研究。
- 稽留流产 /
- 血清 /
- 微量元素 /
- 危险因素 /
- 保护因素
Abstract: Objective To investigate the effects of levels of mercury, manganese, nickel, copper, zinc, arsenic, cadmium, and lead in serum during early pregnancy on missed abortion, and to provide clues for the study of the cause of missed abortion. Methods Twenty-one pairs of aborted patients of the same age, with the same gestational age, and normal early pregnancy were selected, and the levels of serum mercury, manganese, nickel, copper, zinc, arsenic, cadmium, and lead in the two groups of pregnant women were detected. Multivariate Logistic regression was used to analyze the possible influencing factors of missed abortion. Results Compared with the normal early pregnancy group, the serum levels of nickel(t=3.57, P=0.002), copper(t=7.94, P < 0.001), zinc(t=3.60, P=0.002), cadmium(t=4.74, P < 0.001), arsenic(t=2.82, P=0.011), and lead(t=3.46, P=0.002) were higher in the missed abortion group, and the serum manganese levels were lower(t=-8.24, P < 0.001). The binary multivariate logistic regression showed that theOR values of high blood nickel and high blood cadmium were 7.83(95% CI: 1.03-59.68, P =0.037), 3.51(95% CI:2.53-4.87, P =0.004) and 0.68(95% CI:0.47-0.97, P =0.034). Conclusion The levels of Ni, Cd and Mn in pregnant women's serum have a certain effect on the occurrence of missed abortion, and its mechanism needs further study.
- Missed abortion /
- Serum /
- Trace elements /
- Risk factor /
- Protective factor

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图 1 两组孕妇血清中8项微量元素水平热图

Figure 1. Heat map of eight trace elements in serum of two group of pregnant women

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表 1 两组孕妇一般情况比较(x±s)

Table 1. Comparison of the general situation of two groups of pregnant women depression(x±s)

变量	稽留流产组		正常早孕组	t值	P值
年龄(岁)	30.33±6.61	30.62±7.07		-0.60	0.550
孕周(周)	8.00±1.14	8.00±1.14		-0.60	0.550

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表 2 两组孕妇体内血汞、锰、镍、铜、锌、镉、砷及铅水平比较(x±s)

Table 2. Comparison of blood mercury, manganese, nickel, copper, zinc, cadmium, arsenic and lead levels in two groups of pregnant women(x±s)

变量	稽留流产组	正常早孕组	t值	P值
汞(μg/L)	16.89±0.82	16.51±1.01	1.27	0.220
锰(mg/L)	3.55±0.38	10.48±3.75	-8.24	< 0.001
镍(mg/L)	11.57±2.29	9.90±0.71	3.57	0.002
铜(mg/L)	10.90±4.78	2.85±0.44	7.94	< 0.001
锌(mg/L)	16.48±4.34	10.70±4.62	3.60	0.002
砷(μg/L)	59.12±17.75	45.95±12.11	2.82	0.011
镉(μg/L)	101.03±49.64	45.11±15.98	4.74	< 0.001
铅(μg/L)	908.43±225.44	659.86±191.31	3.46	0.002

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表 3 影响稽留流产发生的微量元素的Logistic回归分析模型进行分析

Table 3. Analysis of trace elements affecting the occurrence of missed abortion by Logistic regression model

自变量	β值	S_x	Wald值	OR(95% CI)值	P值
锰	-0.39	0.19	4.43	0.68(0.47~0.97)	0.030
镍	2.06	1.04	3.94	7.83(1.03~59.68)	0.037
锌	-0.02	0.32	0.00	0.98(0.53~1.84)	0.956
砷	-1.74	1.52	0.01	0.01(0.00~1.24)	0.909
铅	0.67	7.79	0.01	1.96(0.00~8.39)	0.931
镉	97.96	34.24	8.19	3.51(2.53~4.87)	0.004

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