孤啡肽与孕期并发症的交互作用对产后抑郁症影响

陈璐; 张研婷; 胡金萍; 拓明花; 牛建梅; 尚玉秀

doi:10.16462/j.cnki.zhjbkz.2020.07.014

孤啡肽与孕期并发症的交互作用对产后抑郁症影响

doi: 10.16462/j.cnki.zhjbkz.2020.07.014

1.
750004 银川, 宁夏医科大学公共卫生与管理学院流行病与卫生统计学系
2.
750001 银川, 宁夏银川市妇幼保健院医院感染管理科
3.
750001 银川, 宁夏银川市妇幼保健院医院妇产科
4.
751700 中卫, 宁夏中卫市中医院妇产科
5.
750001 银川, 宁夏回族自治区人民医院健康管理中心临床营养科

基金项目:

宁夏自然科学基金资助项目 2019AAC03087

详细信息

通讯作者:
尚玉秀, E-mail:shangyx1018@163.com

中图分类号: R749.4
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- 文章访问数: 264
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- PDF下载量: 32
- 被引次数: 0
出版历程
- 收稿日期: 2019-10-30
- 修回日期: 2020-02-20
- 刊出日期: 2020-07-10

The effect of interaction between orphanin FQ and pregnancy complications on postpartum depression

1.
Department of Epidemiology and Health Statistics, School of Public Health and Management, NingXia Medical University, Yinchuan 750004, China
2.
Hospital Infection Management Division, the Maternal and Child Health Hospital of Ningxia city, Yinchuan 750001, China
3.
Department of Gynecology and Obstetrics, the Maternal and Child Health Hospital of Ningxia city, Yinchuan 750001, China
4.
Department of Gynecology and Obstetrics, the Traditional Chinese Medicine Hospital of Zhongwei city in Ningxia, Zhongwei 751700, China
5.
Department of Health Management Center Clinical Nutrition, Region People's Hospital, Ningxia Hui Au-tonomous, Yinchuan 750001, China

Funds:

Ningxia Natural Science Fund Project 2019AAC03087

More Information

Corresponding author: SHANG Yu-xiu, E-mail:shangyx1018@163.com

摘要

摘要: 目的探讨血清孤啡肽（orphanin FQ，OFQ）与孕期并发症及其交互作用对产后抑郁症（postpartum depression，PPD）影响。方法收集银川市与中卫市两所医院200名待产孕妇，应用酶联免疫分析法（enzyme-linked immuno sorbent assay，ELISA）测定血清OFQ水平，采用自行设计的问卷调查家庭因素及孕期并发症，采用爱丁堡产后抑郁量表（Edinburg postnatal depression scale，EPDS）评估产后42 d抑郁状况。结果产后抑郁症组血清OFQ水平48.52（37.56，57.13）pg/ml高于对照组18.37（16.63，25.35）pg/ml，差异有统计学意义（Z=-6.761，P< 0.001）。婆媳关系较差（P=0.014）、有孕期并发症（χ²=6.505，P=0.011）的产妇抑郁检出率高。非条件Logistic回归分析模型分析显示，血清OFQ（OR=21.464，95% CI：6.859~67.167，P< 0.001）与孕期并发症（OR=3.600，95% CI：1.013~12.794，P=0.048）为PPD的危险因素，交互作用模型分析显示血清OFQ与孕期并发症之间存在交互作用（OR=2.229，P=0.021）。结论血清OFQ与孕期并发症是PPD的危险因素，两者同时存在时可增加PPD发生的危险性。
- 产后抑郁 /
- 孤啡肽 /
- 孕期并发症 /
- 交互作用
Abstract: Objective To discuss the effect of orphanin FQ (OFQ) and pregnancy complications and their interaction on postpartum depression (PPD). Methods A total of 200 pregnant women were selected from the Yinchuan Maternal and Child Health Hospital and the Zhongwei Traditional Chinese Medicine Hospital. The OFQ level, family factors, pregnancy complications and 42 days postpartum depression were evaluated by enzyme-linked immunosorbent assay, self-designed questionnaire, and the Edinburg Postnatal Depression Scale. Results The OFQ level 48.52 (37.56, 57.13) pg/ml in the postpartum depression group was higher than that in the control group 18.37 (16.63, 25.35) pg/ml, and the difference was statistically significant (Z=-6.761, P < 0.001). The prevalence rate of postpartum depression with poor relationship between mother-in-law and daughter-in-law (P=0.014) and pregnancy complications (χ²=6.505, P=0.011) were higher than that in normal female. Unconditional logistic regression analysis showed that OFQ (OR=21.464, 95% CI:6.859-67.167, P< 0.001) and pregnancy complications (OR=3.600, 95% CI:1.013-12.794, P=0.048) was risk factors of PPD. Interaction model analysis showed an interaction between OFQ and pregnancy complications (OR=2.229, P=0.021). Conclusion OFQ and pregnancy complications are risk factors for PPD.
- Postpartum depression /
- Orphanin FQ /
- Pregnancy complications /
- Interaction

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表 1 不同社会人口学特征及家庭因素之间抑郁检出率比较

Table 1. Comparison of depression detection rates between different sociodemographic characteristics and family factors

变量	总人数	抑郁人数(n)	检出率(%)	χ²值	P值
年龄(岁)				1.659	0.198
≤30	122	22	18.0
>30	72	8	11.1
民族				0.000	>0.050
汉族	169	26	15.4
其他	25	4	16.0
人均月收入（元）			2.936	0.230
< 3 000	61	12	19.7
3 000~	76	13	17.1
>5 000	57	5	8.8
居住地				0.140	0.708
城市	172	26	15.1
农村	22	4	18.2
文化程度				0.617	0.892
初中及以下	37	7	18.9
高中	37	6	16.2
大专	54	7	13.0
本科及以上	66	10	15.2
夫妻关系				-	> 0.050
较好	186	29	15.6
一般	7	1	14.3
较差	1	0	0.0
婆媳关系				-	0.014
较好	173	24	13.9
一般	17	3	17.6
较差	4	3	75.0
孕期并发症				6.505	0.011
有	31	10	32.3
无	163	20	12.3
负性生活事件				2.089	0.148
有	26	7	26.9
无	168	23	13.7
合计	194	30	15.5
注：“-”为Fisher确切法计算。

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表 2 PPD影响因素的非条件Logistic回归分析模型分析结果

Table 2. Analysis results of unconditional Logistic regression analysis of influencing factors of PPD

变量	β值	S_x	Wald /χ²值	OR(95% CI)值	P < 值
年龄(岁)	-0.006	0.058	0.010	0.994(0.888~1.114)	0.922
民族	0.880	0.818	1.159	2.412(0.486~11.975)	0.282
居住地	1.278	0.940	1.849	3.590(0.569~22.653)	0.174
婚姻状况	-1.746	1.838	0.903	0.174(0.005~6.396)	0.342
血清OFQ	3.066	0.582	27.755	21.464(6.859~67.167)	< 0.001
夫妻关系	-3.348	1.992	2.823	0.035(0.001~1.746)	0.093
婆媳关系	1.957	0.934	4.395	7.079(1.136~44.115)	0.036
孕期并发症	1.281	0.647	3.920	3.600(1.013~12.794)	0.048
负性生活事件	1.180	0.781	2.284	3.256(0.704~15.045)	0.131

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表 3 血清OFQ与家庭因素交互作用的非条件Logistic回归分析模型分析

Table 3. Analysis results of unconditional Logistic regression analysis of the interaction between OFQ and family factors

变量	β值	S_x	Wald /χ²值	OR(95% CI)值	P < 值
夫妻关系	0.193	0.355	0.294	1.212(0.604~2.432)	0.588
婆媳关系	0.286	0.251	1.297	4.688(1.467~14.988)	0.255
孕期并发症	0.802	0.346	5.364	2.229(1.131~4.393)	0.021
负性生活事件	0.513	0.476	1.161	1.670(0.657~4.242)	0.281

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变量	总人数	抑郁人数(n)	检出率(%)	χ²值	P值
年龄(岁)				1.659	0.198
≤30	122	22	18.0
>30	72	8	11.1
民族				0.000	>0.050
汉族	169	26	15.4
其他	25	4	16.0
人均月收入（元）			2.936	0.230
< 3 000	61	12	19.7
3 000~	76	13	17.1
>5 000	57	5	8.8
居住地				0.140	0.708
城市	172	26	15.1
农村	22	4	18.2
文化程度				0.617	0.892
初中及以下	37	7	18.9
高中	37	6	16.2
大专	54	7	13.0
本科及以上	66	10	15.2
夫妻关系				-	> 0.050
较好	186	29	15.6
一般	7	1	14.3
较差	1	0	0.0
婆媳关系				-	0.014
较好	173	24	13.9
一般	17	3	17.6
较差	4	3	75.0
孕期并发症				6.505	0.011
有	31	10	32.3
无	163	20	12.3
负性生活事件				2.089	0.148
有	26	7	26.9
无	168	23	13.7
合计	194	30	15.5
注：“-”为Fisher确切法计算。

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文章访问数: 264
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孤啡肽与孕期并发症的交互作用对产后抑郁症影响

doi: 10.16462/j.cnki.zhjbkz.2020.07.014

通讯作者:
尚玉秀, E-mail:shangyx1018@163.com

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The effect of interaction between orphanin FQ and pregnancy complications on postpartum depression

Corresponding author: SHANG Yu-xiu, E-mail:shangyx1018@163.com

计量

目录

留言板

孤啡肽与孕期并发症的交互作用对产后抑郁症影响

doi: 10.16462/j.cnki.zhjbkz.2020.07.014

通讯作者: 尚玉秀, E-mail:shangyx1018@163.com

计量

出版历程

The effect of interaction between orphanin FQ and pregnancy complications on postpartum depression

Corresponding author: SHANG Yu-xiu, E-mail:shangyx1018@163.com

计量

出版历程

目录

通讯作者:
尚玉秀, E-mail:shangyx1018@163.com