大连市成年人静息心率与代谢综合征的关系

陈泽琨; 王颖; 于雪; 窦宇琪; 马德福

doi:10.16462/j.cnki.zhjbkz.2021.06.009

大连市成年人静息心率与代谢综合征的关系

doi: 10.16462/j.cnki.zhjbkz.2021.06.009

100191 北京，北京大学医学部公共卫生学院社会医学与健康教育学系

基金项目:

国家自然科学基金 81573130

北京市自然科学基金 S160004

北京市自然科学基金 7172117

详细信息

通讯作者:
马德福，E-mail: madefu@bjmu.edu.cn

中图分类号: R589
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出版历程
- 收稿日期: 2020-09-07
- 修回日期: 2020-12-09
- 刊出日期: 2021-06-10

Association between resting heart rate and metabolic syndrome in adults in Dalian

Department of Social Medicine and Health Education, School of Public Health, Peking University Health Science Center, Beijing 100191, China

Funds:

National Natural Science Foundation of China 81573130

Beijing Municipal Natural Science Foundation S160004

Beijing Municipal Natural Science Foundation 7172117

More Information

Corresponding author: MA De-fu, E-mail: madefu@bjmu.edu.cn

摘要

摘要: 目的探究大连市成年人静息心率(resting heart rate, RHR)与代谢综合征(metabolic syndrome, MS)之间的关系。方法选取2015年1月1日-2017年12月31日在辽宁省大连市大连医科大学附属医院体检中心体检的人员作为研究对象，采用χ²检验对不同心率组间MS患病率进行比较。利用二元Logistic回归分析模型分析RHR与MS之间的关系。结果共纳入研究对象65 745例，其中男性36 356例，占比55.3%，女性29 389例，占比44.7%。Logistic回归分析模型分析结果表明，在校正年龄、身高、体重后，RHR每增加10次/min，全人群的MS患病风险会增加16%(OR=1.16, 95% CI: 1.13~1.20)。与RHR＜70次/min的研究对象相比，RHR≥90次/min的研究对象中男性(OR=1.51, 95% CI: 1.34~1.71)和女性(OR=1.89, 95% CI: 1.49~2.40)都有着更高的MS患病风险；此外，与正常BMI(＜24 kg/m²)、正常RHR(＜80次/min)的研究对象相比，高BMI且高RHR者中女性(OR=14.87, 95% CI: 11.18~19.77)和男性(OR=6.22, 95% CI: 5.40~7.17) 都有着更高的MS患病风险。结论本研究发现，随着RHR的加快，MS的患病率逐渐上升。此外，RHR和BMI结合应用可以增加RHR作为MS标志物的效力，RHR可以与BMI联合作为一个潜在的临床测量指标。
- 静息心率 /
- 代谢综合征 /
- 患病率
Abstract: Objective Investigate the intrinsic relationship between resting heart rate (RHR) and metabolic syndrome (MS). Methods In this study, people who had physical examination in the Physical Examination Center of Dalian Medical University Affiliated Hospital of Dalian City, Liaoning Province from January 1, 2015 to December 31, 2017 were selected as the study subjects. The prevalence of MS among groups with different heart rates was compared by chi-square test. Binary Logistic regression analysis model was used to analyze the relationship between RHR and MS. Results 65 745 subjects were included in the study, including 36 356 males (55.3%) and 29 389 females(44.7%). Logistic regression analysis showed that after adjusting for age, height and weight, the risk of MS increased by 16% for every 10 increase in RHR per minute (OR=1.16, 95% CI: 1.13-1.20). Compared with subjects with a RHR of < 70 bpm, subjects with a RHR of ≥90 bpm had higher odds of MS: 1.51(OR=1.51, 95% CI: 1.34-1.71) in males and 1.89 (OR=1.89, 95% CI: 1.49-2.40) in females. In addition, compared with subjects with normal body mass index (BMI) (< 24 kg/m²) and normal RHR (< 80 bpm), subjects with high BMI and high RHR had higher odds of MS: 14.87 (OR=14.87, 95% CI: 11.18-19.77) in females and 6.22(OR=6.22, 95% CI: 5.40-7.17) in males. Conclusion In this study, the prevalence of metabolic syndrome was found to increase with increased resting heart rate. In addition, combining RHR and BMI can increase the efficacy of RHR as a marker of metabolic syndrome, and RHR can be combined with BMI as a potential clinical measure indicator.
- Resting heart rate /
- Metabolic syndrome /
- Prevalence rate

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图 1 2015-2017年大连市成年人不同性别代谢综合征患病率(%)

Figure 1. Prevalence of metabolic syndrome by sex in Dalian adults from 2015 to 2017 (%)

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图 2 2015-2017年大连市成年人静息心率与BMI对代谢综合征的联合影响分析

Figure 2. Analysis of the combined effect of resting heart rate and BMI on metabolic syndrome in Dalian adults from 2015 to 2017

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表 1 2015-2017年大连市成年男性不同的RHR分组水平下的变量特征(x±s)

Table 1. Variable characteristics of adult males in Dalian under different RHR grouping levels from 2015 to 2017 (x±s)

特征	静息心率(次/min)				F值	P值
特征	＜70 (n=19 232)	70~＜80 (n=11 280)	80~＜90 (n=4 259)	≥90 (n=1 585)	F值	P值
年龄(岁)	47.76±14.13	47.16±14.29	46.91±14.40	47.06±15.07	7.081	＜0.001
体格指标
身高(cm)	173.32±6.21	173.44±6.23	173.44±6.13	173.21±6.40	1.453	0.369
体重(kg)	75.74±10.38	76.14±10.55	76.12±10.66	75.66±10.99	4.390	0.019
BMI(kg/m²)	25.19±3.02	25.30±3.13	25.29±3.22	25.20±3.26	3.388	0.031
腰围(cm)	88.48±8.23	89.01±8.39	89.16±8.65	89.11±8.74	14.511	＜0.001
SBP(mm Hg)	129.71±15.22	131.16±15.09	132.37±15.13	134.32±15.49	77.653	＜0.001
DBP(mm Hg)	78.51±10.41	79.77±10.35	80.55±10.39	81.43±10.36	87.443	＜0.001
实验室检查(mmol/L)
UA	388.18±81.48	391.25±82.60	390.86±85.62	391.17±86.98	3.816	0.007
FBG	5.92±1.51	6.03±1.68	6.14±1.84	6.25±1.96	39.909	＜0.001
TC	4.95±0.92	4.99±0.94	4.99±0.93	5.08±1.05	12.427	＜0.001
TG	1.74±1.38	1.88±1.58	1.92±1.56	2.05±2.56	39.925	＜0.001
HDL-C	1.21±0.29	1.20±0.28	1.20±0.29	1.21±0.31	4.113	0.002

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表 2 2015-2017年大连市成年女性不同的静息心率分组水平下的变量特征(x±s)

Table 2. Variable characteristics of adult famales in Dalian under different RHR grouping levels from 2015 to 2017 (x±s)

特征	静息心率(次/min)				F值	P值
特征	＜70 (n=14 551)	70~＜80 (n=9 787)	80~＜90 (n=3 701)	≥90 (n=1 350)	F值	P值
年龄(岁)	44.79±13.81	43.61±14.01	42.86±14.11	43.45±15.02	26.641	＜0.001
体格指标
身高(cm)	162.60±5.84	162.60±5.79	162.54±5.81	162.64±5.95	0.125	0.880
体重(kg)	61.34±8.84	61.32±8.95	61.44±9.01	61.82±9.60	1.382	0.371
BMI(kg/m²)	23.21±3.19	23.20±3.23	23.25±3.20	23.37±3.39	1.266	0.317
腰围(cm)	79.61±8.73	79.57±8.77	79.61±8.66	80.50±9.16	4.582	0.002
SBP(mm Hg)	122.36±16.48	123.24±16.08	124.47±16.14	126.92±16.42	43.798	＜0.001
DBP(mm Hg)	72.30±10.03	73.48±10.00	74.32±9.88	75.58±10.22	81.957	＜0.001
实验室检查(mmol/L)
UA	280.06±62.90	279.37±63.24	281.18±66.24	281.55±65.94	0.988	0.395
FBG	5.46±1.04	5.50±1.10	5.57±1.28	5.71±1.41	28.527	＜0.001
TC	4.99±0.98	4.97±0.99	4.94±0.97	5.01±0.98	3.626	0.006
TG	1.24±0.81	1.27±0.84	1.31±0.81	1.31±0.78	10.105	＜0.001
HDL-C	1.47±0.32	1.47±0.32	1.46±0.31	1.47±0.31	3.043	0.050

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表 3 2015-2017年大连市成年人不同RHR分组对代谢综合征患病风险的影响模型分析结果[OR(95% CI)]

Table 3. Model analysis of the influence of different RHR groups on metabolic syndrome risk factors in Dalian adults from 2015 to 2017 [OR (95% CI)]

静息心率(次/min)	总体组		男性组		女性组
静息心率(次/min)	模型1	模型2	模型1	模型2	模型1	模型2
< 70	1.00	1.00	1.00	1.00	1.00	1.00
70~＜80	1.13(1.08~1.19) ^a	1.19(1.13~1.25) ^a	1.23(1.17~1.30) ^a	1.22(1.15~1.30) ^a	1.08(0.95~1.22)	1.13(0.99~1.29)
80~＜90	1.27(1.19~1.35) ^a	1.36(1.27~1.46) ^a	1.37(1.27~1.48) ^a	1.38(1.27~1.49) ^a	1.32(1.12~1.55) ^a	1.45(1.21~1.73) ^a
≥90	1.42(1.29~1.57) ^a	1.55(1.39~1.72) ^a	1.46(1.30~1.64) ^a	1.51(1.34~1.71) ^a	1.86(1.49~2.31) ^a	1.89(1.49~2.40) ^a
每增加10	1.13(1.10~1.15) ^a	1.16(1.13~1.20) ^a	1.16(1.13~1.19) ^a	1.17(1.13~1.20) ^a	1.19(1.12~1.26) ^a	1.22(1.14~1.30) ^a
注：^a P＜0.05。

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