中链饱和脂肪酸与口腔癌发病风险的关联性

苏珏; 李滟铌; 范毅; 王思杰; 徐明明; 周楠; 何其璇; 俞道煊; 吕吉荣; 陈青; 汪晶; 施斌; 邱宇; 林李嵩; 郑晓燕; 潘丽珍; 陈法; 汪靖; 何保昌; 刘凤琼

doi:10.16462/j.cnki.zhjbkz.2021.08.018

文章导航 > 中华疾病控制杂志 > 2021 > 25(8): 975-980

苏珏, 李滟铌, 范毅, 王思杰, 徐明明, 周楠, 何其璇, 俞道煊, 吕吉荣, 陈青, 汪晶, 施斌, 邱宇, 林李嵩, 郑晓燕, 潘丽珍, 陈法, 汪靖, 何保昌, 刘凤琼. 中链饱和脂肪酸与口腔癌发病风险的关联性[J]. 中华疾病控制杂志, 2021, 25(8): 975-980. doi: 10.16462/j.cnki.zhjbkz.2021.08.018

引用本文:

SU Jue, LI Yan-ni, FAN Yi, WANG Si-jie, XU Ming-ming, ZHOU Nan, HE Qi-xuan, YU Dao-xuan, LYU Ji-rong, CHEN Qing, WANG Jing, SHI Bin, QIU Yu, LIN Li-song, ZHENG Xiao-yan, PAN Li-zhen, CHEN Fa, WANG Jing, HE Bao-chang, LIU Feng-qiong. Relationship between medium-chain saturated fatty acids and risk of oral cancer[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(8): 975-980. doi: 10.16462/j.cnki.zhjbkz.2021.08.018

Citation:

SU Jue, LI Yan-ni, FAN Yi, WANG Si-jie, XU Ming-ming, ZHOU Nan, HE Qi-xuan, YU Dao-xuan, LYU Ji-rong, CHEN Qing, WANG Jing, SHI Bin, QIU Yu, LIN Li-song, ZHENG Xiao-yan, PAN Li-zhen, CHEN Fa, WANG Jing, HE Bao-chang, LIU Feng-qiong. Relationship between medium-chain saturated fatty acids and risk of oral cancer[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(8): 975-980. doi: 10.16462/j.cnki.zhjbkz.2021.08.018

引用本文:

Citation:

SU Jue, LI Yan-ni, FAN Yi, WANG Si-jie, XU Ming-ming, ZHOU Nan, HE Qi-xuan, YU Dao-xuan, LYU Ji-rong, CHEN Qing, WANG Jing, SHI Bin, QIU Yu, LIN Li-song, ZHENG Xiao-yan, PAN Li-zhen, CHEN Fa, WANG Jing, HE Bao-chang, LIU Feng-qiong. Relationship between medium-chain saturated fatty acids and risk of oral cancer[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(8): 975-980. doi: 10.16462/j.cnki.zhjbkz.2021.08.018

中链饱和脂肪酸与口腔癌发病风险的关联性

doi: 10.16462/j.cnki.zhjbkz.2021.08.018

1.
350108 福州，福建医科大学公共卫生学院流行病与卫生统计学系
2.
350108 福州，福建医科大学公共卫生学院实验中心
3.
350004 福州，福建医科大学附属第一医院口腔颌面外科

基金项目:

福建医科大学公共卫生学院大学生科研创新项目 202004

国家自然科学基金 81503171

详细信息

通讯作者:
刘凤琼, E-mail: lfq@fjmu.edu.cn

中图分类号: R739
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- 被引次数: 0
出版历程
- 收稿日期: 2020-08-20
- 修回日期: 2020-11-18
- 网络出版日期: 2021-08-24
- 刊出日期: 2021-08-10

Relationship between medium-chain saturated fatty acids and risk of oral cancer

1.
Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350108, China
2.
The Center of Experiment, School of Public Health, Fujian Medical University, Fuzhou 350108, China
3.
Department of Stomatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350004, China

Funds:

Innovative Research Program for Undergraduate of Public Health School of Fujian Medical University 202004

National Natural Science Foundation of China 81503171

More Information

Corresponding author: LIU Feng-qiong, E-mail: lfq@fjmu.edu.cn

摘要

摘要: 目的探讨膳食中链饱和脂肪酸与口腔癌发病的关联。方法本病例对照研究以面访式问卷的形式调查2013年11月14日至2019年3月21日在福建医科大学附属第一医院口腔颌面外科确诊的225例新发口腔癌患者及527例健康对照。以对照组中能量校正后的各类脂肪酸每日摄入量的中位数进行分组，进行非条件Logistic回归分析模型分析、分层分析及相乘交互作用分析。结果高水平组的总中链饱和脂肪酸、辛酸、癸酸、十一烷酸及月桂酸等与口腔癌的发病风险呈正相关，其调整后的OR值及其95% CI值分别为3.19(95% CI: 2.17~4.69)、2.54(95% CI: 1.75~3.69)、2.56(95% CI: 1.76~3.71)、5.00(95% CI: 3.27~7.64)和3.09(95% CI: 2.10~4.54)。在不吸烟者中，辛酸和癸酸与口腔癌发生风险呈正相关，且无论是否饮酒，其均能增加口腔癌的发病风险；各亚组均发现高总中链饱和脂肪酸、十一烷酸及月桂酸摄入量与口腔癌发生风险呈正相关。此外，中链饱和脂肪酸与吸烟、饮酒存在相乘交互作用。结论较高水平的膳食中链饱和脂肪酸可能会增加口腔癌的发病风险。
- 口腔癌 /
- 膳食中链饱和脂肪酸 /
- 危险因素 /
- 吸烟 /
- 饮酒
Abstract: Objective To investigate the association between dietary medium-chain saturated fatty acids and the risk of oral cancer. Methods A case-control study was conducted in 225 patients with diagnosed oral cancer and 527 controls. All participants were recruited from the First Affiliated Hospital of Fujian Medical University from November 14, 2013 to March 21, 2019. The median daily intake of all kinds of fatty acids after energy correction in the control group was divided into groups. Unconditional Logistic regression analysis stratified analysis and multiplicative interaction analysis were performed, stratified analysis and multiplicative interaction analysis were performed to investigate the relationship between medium chain saturated fatty acids and the risk of oral cancer. Results Compared with the low-level group, the total medium-chain saturated fatty acids, octanoic acid, decanoic acid, undecanoic acid and lauric acid in the high-level group may increase the risk of oral cancer. The adjusted OR and 95% CI were 3.19 (95% CI: 2.17-4.69), 2.54 (95% CI: 1.75-3.69)、2.56 (95% CI: 1.76-3.71)、5.00 (95% CI: 3.27-7.64) and 3.09 (95% CI: 2.10-4.54), respectively. Stratified analysis showed that octanoic acid and decanoic acid were risk factors of oral cancer among non-smokers, and they may also increased the risk of oral cancer regardless of drinking status. There was a positive correlation between the daily intake of total medium-chain saturated fatty acids, undecanoic acid and lauric acid and the risk for oral cancer regardless of smoking and drinking status. In addition, there were multiplicative interactions between medium-chain saturated fatty acids and smoking or drinking status. Conclusion A higher level of dietary medium-chain saturated fatty acids may increase the risk of oral cancer.
- Oral cancer /
- Dietary medium chain saturated fatty acid /
- Risk factor /
- Smoking /
- Drinking

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图 1 病例组和对照组中链饱和脂肪酸每日摄入量的比较

Figure 1. Comparison of daily intake of medium-chain saturated fatty acids between case and control groups

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表 1 病例组与对照组的一般人口学特征比较[n(%)]

Table 1. Comparison of general characteristics between the case group and the control group [n(%)]

特征	病例组	对照组	χ²值	P值
年龄(岁)			72.494	< 0.001
< 60	108(48.00)	417(79.13)
≥60	117(52.00)	110(20.87)
性别			2.690	0.101
男	121(53.78)	249(47.25)
女	104(46.22)	278(52.75)
文化程度			17.217	< 0.001
文盲	16(7.11)	41(7.78)
小学及初中	153(68.00)	275(52.18)
高中及以上	56(24.89)	211(40.04)
婚姻状况			5.697	0.017
已婚	205(91.11)	446(84.63)
未婚及其他	20(8.89)	81(15.37)
职业			7.178	< 0.001
农民	84(37.33)	145(27.51)
其他	141(62.67)	382(72.49)
居住地			3.522	0.061
农村	135(60.00)	277(52.56)
城市	90(40.00)	250(47.44)
BMI(kg/m²)			7.974	0.019
< 18.5	20(8.89)	40(7.59)
18.5~ < 24.0	150(66.67)	303(57.50)
≥24.0	55(24.44)	184(34.91)
吸烟			4.979	0.026
无	137(60.89)	365(69.26)
有	88(39.11)	162(30.74)
饮酒			17.572	< 0.001
无	148(65.78)	422(80.08)
有	77(34.22)	105(19.92)
肿瘤家族史			1.064	0.302
无	191(84.89)	462(87.67)
有	34(15.11)	65(12.33)
注：表中数据收集于福建省2013年11月14日至2019年3月21日。

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表 2 中链饱和脂肪酸与口腔癌关联的非条件Logistic回归分析模型分析

Table 2. The unconditional Logistic regression analysis of medium-chain saturated fatty acids on oral cancer

变量(mg/d)	OR(95% CI)值	P值	OR(95% CI)值^a	P值
总中链饱和脂肪酸
≤29.40	1.00		1.00
>29.40	3.34(2.34~4.76)	< 0.001	3.19(2.17~4.69)	< 0.001
C6∶0
≤3.71	1.00		1.00
>3.71	0.80(0.58~1.09)	0.156	0.79(0.56~1.11)	0.170
C8∶0
≤6.06	1.00		1.00
>6.06	2.80(1.99~3.95)	< 0.001	2.54(1.75~3.69)	< 0.001
C10∶0
≤7.46	1.00		1.00
>7.46	2.68(1.91~3.76)	< 0.001	2.56(1.76~3.71)	< 0.001
C11∶0
≤4.75	1.00		1.00
>4.75	5.10(3.45~7.55)	< 0.001	5.00(3.27~7.64)	< 0.001
C12∶0
≤7.54	1.00		1.00
>7.54	3.23(2.27~4.60)	< 0.001	3.09(2.10~4.54)	< 0.001
注：^a调整年龄、性别、文化程度、婚姻状况、职业、居住地、BMI、肿瘤家族史、饮酒。

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表 3 中链饱和脂肪酸与口腔癌的分层分析

Table 3. Stratified analysis on the association between medium-chain saturated fatty acids and the risk of oral cancer

变量(mg/d)	调整OR(95% CI)值^a		调整OR(95% CI)值^b
变量(mg/d)	吸烟	不吸烟	饮酒	不饮酒
总中链饱和脂肪酸
≤29.40	1.00	1.00	1.00	1.00
>29.40	1.90(1.03~3.53)	4.72(2.76~8.07)	3.23(1.58~6.59)	3.28(2.04~5.28)
C6∶0
≤3.71	1.00	1.00	1.00	1.00
>3.71	0.89(0.49~1.64)	0.73(0.48~1.12)	0.89(0.44~1.77)	0.74(0.50~1.11)
C8∶0
≤6.06	1.00	1.00	1.00	1.00
>6.06	1.63(0.88~3.02)	3.53(2.14~5.84)	2.06(1.04~4.10)	2.79(1.76~4.43)
C10∶0
≤7.46	1.00	1.00	1.00	1.00
>7.46	1.56(0.84~2.89)	3.75(2.27~6.22)	2.29(1.15~4.56)	2.73(1.73~4.32)
C11∶0
≤4.75	1.00	1.00	1.00	1.00
>4.75	3.47(1.79~6.72)	7.50(4.06~13.85)	4.02(1.93~8.36)	6.11(3.50~10.68)
C12∶0
≤7.54	1.00	1.00	1.00	1.00
>7.54	2.15(1.15~4.04)	4.03(2.41~6.75)	2.53(1.26~5.08)	3.41(2.11~5.51)
注：^a调整年龄、性别、文化程度、婚姻状况、职业、居住地、BMI、肿瘤家族史、饮酒；^b调整年龄、性别、文化程度、婚姻状况、职业、居住地、BMI、肿瘤家族史、吸烟。

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表 4 中链饱和脂肪酸与吸烟、饮酒的交互作用[n(%)]

Table 4. Analysis of the interaction between medium-chain saturated fatty acids and smoking and drinking [n(%)]

变量(mg/d)		病例组	对照组	OR(95% CI)值
总中链饱和脂肪酸	吸烟^a
≤29.40	无	21(9.33)	176(33.40)	1.00
≤29.40	有	31(13.78)	88(16.70)	1.62(0.78~3.35)
>29.40	无	116(51.56)	189(35.86)	4.83(2.81~8.28)
>29.40	有	57(25.33)	74(14.04)	3.01(1.51~6.01)
总中链饱和脂肪酸×吸烟				1.48(0.91~2.40)
总中链饱和脂肪酸	饮酒^b
≤29.40	无	28(12.44)	202(38.33)	1.00
≤29.40	有	24(10.67)	62(11.76)	2.57(1.30~5.10)
>29.40	无	120(53.33)	220(41.75)	3.27(2.03~5.26)
>29.40	有	53(23.56)	43(8.16)	7.81(4.14~14.72)
总中链饱和脂肪酸×饮酒				3.50(2.11~5.83)
C6∶0	吸烟^a
≤3.71	无	78(34.67)	184(34.91)	1.00
≤3.71	有	47(20.89)	79(14.99)	0.81(0.44~1.50)
>3.71	无	59(26.22)	181(34.35)	0.73(0.48~1.12)
>3.71	有	41(18.22)	83(15.75)	0.73(0.38~1.37)
C6∶0×吸烟				0.88(0.53~1.45)
C6∶0	饮酒^b
≤3.71	无	85(37.78)	214(40.60)	1.00
≤3.71	有	40(17.78)	49(9.30)	2.04(1.14~3.63)
>3.71	无	63(28.00)	208(39.47)	0.74(0.49~1.11)
>3.71	有	37(16.44)	56(10.63)	1.88(1.06~3.35)
C6∶0×饮酒				1.67(0.99~2.81)
C8∶0	吸烟^a
≤6.06	无	26(11.56)	174(33.02)	1.00
≤6.06	有	33(14.67)	89(16.89)	1.45(0.72~2.90)
>6.06	无	111(49.33)	191(36.24)	3.55(2.14~5.88)
>6.06	有	55(24.44)	73(13.85)	2.29(1.17~4.49)
C8∶0×吸烟				1.32(0.80~2.15)
C8∶0	饮酒^b
≤6.06	无	32(14.22)	203(38.51)	1.00
≤6.06	有	27(12.00)	60(11.39)	2.90(1.50~5.59)
C8∶0	饮酒^b
>6.06	无	116(51.56)	219(41.56)	2.83(1.79~4.49)
>6.06	有	50(22.22)	45(8.54)	5.88(3.16~10.97)
C8∶0×饮酒				2.74(1.65~4.55)
C10∶0	吸烟^a
≤7.46	无	26(11.55)	176(33.40)	1.00
≤7.46	有	35(15.56)	87(16.51)	1.54(0.77~3.07)
>7.46	无	111(49.33)	189(35.86)	3.81(2.29~6.32)
>7.46	有	53(23.56)	75(14.23)	2.26(1.15~4.41)
C10∶0×吸烟				1.25(0.76~2.04)
C10∶0	饮酒^b
≤7.46	无	33(14.67)	203(38.51)	1.00
≤7.46	有	28(12.44)	60(11.39)	2.80(1.46~5.37)
>7.46	无	115(51.11)	219(41.56)	2.79(1.76~4.41)
>7.46	有	49(21.78)	45(8.54)	6.01(3.22~11.20)
C10∶0×饮酒				2.85(1.71~4.73)
C11∶0	吸烟^a
≤4.75	无	14(6.22)	174(33.02)	1.00
≤4.75	有	23(10.22)	90(17.08)	1.75(0.77~3.98)
>4.75	无	123(54.67)	191(36.24)	7.72(4.16~14.36)
>4.75	有	65(28.89)	72(13.66)	5.32(2.51~11.29)
C11∶0×吸烟				2.00(1.23~3.25)
C11∶0	饮酒^b
≤4.75	无	17(7.56)	203(38.52)	1.00
≤4.75	有	20(8.89)	61(11.57)	3.87(1.79~8.39)
>4.75	无	131(58.22)	219(41.56)	6.26(3.58~10.96)
>4.75	有	57(25.33)	44(8.35)	13.50(6.71~27.15)
C11∶0×饮酒				3.61(2.19~5.94)
C12∶0	吸烟^a
≤7.54	无	24(10.67)	176(33.40)	1.00
≤7.54	有	29(12.89)	87(16.51)	1.35(0.66~2.79)
>7.54	无	113(50.22)	189(35.86)	4.14(2.47~6.95)
>7.54	有	59(26.22)	75(14.23)	2.78(1.42~5.45)
C12∶0×吸烟				1.55(0.95~2.52)
C12∶0	饮酒^b
≤7.54	无	28(12.44)	204(38.70)	1.00
≤7.54	有	25(11.11)	59(11.20)	2.98(1.51~5.90)
>7.54	无	120(53.33)	218(41.37)	3.45(2.14~5.57)
>7.54	有	52(23.12)	46(8.73)	7.45(3.95~14.06)
C12∶0×饮酒				3.09(1.87~5.11)
注：^a调整年龄、性别、文化程度、婚姻状况、职业、居住地、BMI、肿瘤家族史、饮酒；^b调整年龄、性别、文化程度、婚姻状况、职业、居住地、BMI、肿瘤家族史、吸烟。

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