Assessing the excess mortality related to short-term exposure to PM2.5 in Nanjing from 2013 to 2019
-
摘要:
目的 评估2013―2019年南京市大气细颗粒物(fine particulate matter, PM2.5)短期暴露对人群死亡的影响及其所致超额死亡人数。 方法 收集环保、气象、户籍人口和死因监测数据,采用广义相加模型分析PM2.5对人群死亡的影响,得到暴露-反应关系系数,估算因PM2.5短期暴露导致人群超额死亡人数。 结果 在2013―2019年,南京市大气PM2.5质量浓度增加,居民各系统疾病死亡风险随着升高(均有P < 0.05)。PM2.5短期暴露引发的人群非意外总死亡中超额死亡人数为8 479人,占人群非意外总死亡的3.21%;呼吸系统疾病、恶性肿瘤疾病、循环系统疾病、脑血管疾病和心血管疾病的超额死亡人数及其占所属疾病类型总死亡人数的比例分别为1 202人(4.32%)、1 424人(1.60%)、4 505人(3.94%)、2 613人(3.79%)和1 856人(4.14%)。 结论 2013―2019年南京市PM2.5质量浓度和其造成的居民超额死亡人数呈降低趋势,南京市大气污染防治健康收益良好。 Abstract:Objective To estimate impact of residents death and excess mortality induced by fine particulate matter (PM2.5) short-term exposure in Nanjing from 2013 to 2019. Methods Environmental data, meteorological data, population of community residents and death surveillance data in Nanjing was collected. Generalized additive model of time series analysis was used to analyze the effects of PM2.5 on risk of death, and estimated excess mortality related to PM2.5. Results The risk of residents death increased while the concentration of PM2.5 increased in Nanjing from 2013 to 2019. The number of excess mortality due to PM2.5, including non-accidental causes, respiratory diseases, cancer, circulatory diseases, cerebrovascular diseases, cardiovascular diseases was 8 479(3.21%), 1 202(4.32%), 1 424(1.60%), 4 505(3.94%), 2 613(3.79%) and 1 856(4.14%). Conclusion The excess mortality caused by PM2.5 was decreasing while the concentration of PM2.5 decreased in Nanjing from 2013 to 2019. The health benefits of air pollution prevention and control in Nanjing are good. -
Key words:
- Ambient fine particulate matter /
- Excess death /
- Health risk assessment
-
表 1 2013―2019年南京市大气污染物、气象因素和居民死亡情况
Table 1. Air pollutants, meteorological factors and number of residents death in Nanjing from 2013 to 2019
变量 Min P25 M P75 Max 大气污染物 PM2.5(μg/m3) 6.11 28.70 44.79 69.41 327.44 O3(μg/m3) 8.40 61.95 90.85 129.35 316.00 SO2(μg/m3) 4.00 9.93 15.11 23.60 139.00 NO2(μg/m3) 9.43 31.21 41.57 56.33 140.67 气象因素 日均温度(℃) -6.70 8.70 17.80 63.00 34.50 日均相对湿度(%) 28.00 24.30 73.00 83.00 100.00 健康效应指标(例/d) 非意外死亡 54 91 101 115 170 呼吸系统疾病死亡 0 8 10 14 31 恶性肿瘤疾病死亡 15 31 35 39 57 循环系统疾病死亡 20 37 44 51 98 脑血管疾病死亡 9 22 26 31 69 心血管疾病死亡 5 14 17 21 41 表 2 不同模型中南京市大气PM2.5浓度每增加10 μg/m3时日死亡数增加的超额危险度(%)
Table 2. Excess risk for every 10 μg/m3 increase in PM2.5 concentration by different pollutant model in Nanjing (%)
污染物 自由度 非意外死亡 呼吸系统疾病死亡 恶性肿瘤疾病死亡 循环系统疾病死亡 脑血管疾病死亡 心血管疾病死亡 ER (95% CI)值 ER (95% CI)值 ER (95% CI)值 ER (95% CI)值 ER (95% CI)值 ER (95% CI)值 PM2.5 6 0.92 0.75~1.08 1.17 0.76~1.59 0.47 0.24~0.70 1.14 0.91~1.37 1.15 0.86~1.43 1.10 0.78~1.43 PM2.5 7 1.05 0.87~1.23 1.29 0.83~1.76 0.54 0.28~0.79 1.28 1.03~1.54 1.25 0.93~1.57 1.33 0.97~1.68 PM2.5 8 1.05 0.87~1.23 1.30 0.84~1.76 0.54 0.28~0.79 1.27 1.01~1.52 1.25 0.93~1.57 1.32 0.97~1.68 PM2.5+O3 7 0.57 0.44~0.69 0.79 0.46~1.13 0.27 0.11~0.44 0.67 0.49~0.85 0.67 0.45~0.88 0.67 0.42~0.92 PM2.5+SO2 7 0.97 0.82~1.12 1.27 0.89~1.65 0.47 0.26~0.68 1.18 0.97~1.39 1.14 0.87~1.40 1.25 0.95~1.54 PM2.5+NO2 7 0.84 0.71~0.96 1.01 0.68~1.35 0.46 0.27~0.64 1.03 0.85~1.21 1.06 0.83~1.28 1.00 0.74~1.26 表 3 2013―2019年南京市大气PM2.5污染造成的超额死亡人数
Table 3. Excess mortality caused by ambient PM2.5 in Nanjing from 2013 to 2019
年份 非意外总超额死亡人数 呼吸系统疾病超额死亡人数 恶性肿瘤疾病超额死亡人数 循环系统疾病超额死亡人数 脑血管疾病超额死亡人数 心血管疾病超额死亡人数 WHO标准 中国标准 WHO标准 中国标准 WHO标准 中国标准 WHO标准 中国标准 WHO标准 中国标准 WHO标准 中国标准 2013 1 965 749 294 117 330 120 1 052 410 591 226 454 181 2014 1 754 514 270 84 305 86 895 267 509 152 380 113 2015 1 302 332 190 50 225 56 679 176 394 99 280 76 2016 1 072 219 143 31 178 35 582 122 349 72 228 48 2017 799 116 102 18 131 18 431 62 254 36 173 26 2018 857 180 111 26 139 27 462 99 274 59 183 39 2019 730 85 92 12 116 13 404 47 242 28 158 19 合计 8 479 2 195 1 202 338 1 424 355 4 505 1183 2 613 672 1 856 502 -
[1] Cohen AJ, Brauer M, Burnett R, et al. Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015[J]. Lancet, 2017, 389(10082): 1907-1918. DOI: 10.1016/S0140-6736(17)30505-6. [2] Lelieveld J, Evans JS, Fnais M, et al. The contribution of outdoor air pollution sources to premature mortality on a global scale[J]. Nature, 2015, 525(7569): 367-371. DOI: 10.1038/nature15371. [3] GBD 2019 Risk Factors Collaborators. Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019[J]. Lancet, 2020, 396: 1223-1249. DOI: 10.1016/S0140-6736(20)30752-2. [4] Ostro B, Spadaro JV, Gumy S, et al. Assessing the recent estimates of the global burden of disease for ambient air pollution: Methodological changes and implications for low- and middle-income countries[J]. Environ Res, 2018, 166: 713-725. DOI: 10.1016/j.envres.2018.03.001. [5] 孙金金, 黄琳, 龚康佳, 等. 2014―2019年北京和南京地区PM2.5和臭氧浓度相关性研究[J]. 南京信息工程大学学报(自然科学版), 2020, 12(6): 656-664. DOI: 10.13878/j.cnki.jnuist.2020.06.002.Sun JJ, Huang L, Gong KJ, et al. Correlation between surface PM2.5 and ozone during 2014-2019 in Beijing and Nanjing[J]. Journal of Nanjing University of Information Science and Technology (Natural Science Edition), 2020, 12(6): 656-664. DOI: 10.13878/j.cnki.jnuist.2020.06.002. [6] 路凤, 李亚伟, 李成橙, 等. 时间序列分析在空气污染与健康领域的应用及其R软件实现[J]. 中国卫生统计, 2018, 35(4): 622-625. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGWT201804041.htmLu F, Li YW, Li CC, et al. Application of time series analysis in air pollution and health and its R software implementation[J]. Chin J Health Statistics, 2018, 35(4): 622-625. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGWT201804041.htm [7] Kan H, London SJ, Chen G, et al. Season, sex, age, and education as modifiers of the effects of outdoor air pollution on daily mortality in Shanghai, China: The Public Health and Air Pollution in Asia (PAPA) Study[J]. Environ Health Perspect, 2008, 116(9): 1183-1188. DOI: 10.1289/ehp.10851. [8] 中华人民共和国卫生健康委员会. 大气污染人群健康风险评估技术规范: WS/T 666-2019[S]. 北京: 中国标准出版社, 2019.National Health Commission of the People's Republic of China, Technical specifications for health risk assessment of ambient air pollution: WS/T 666-2019[S]. Beijing: Standards Press of China, 2019. [9] 国务院. 大气污染防治行动计划[EB/OL]. (2013-09-12)[2021-03-15]. http://www.gov.cn/jrzg/2013-09/12/content_2486918.htm.State Council. Air Pollution Prevention and Control Action Plan[EB/OL]. (2013-09-12)[2021-03-15]. http://www.gov.cn/jrzg/2013-09/12/content_2486918.htm. [10] 南京市生态环境局. 南京市"十三五"生态环境保护规划[EB/OL]. (2017-06-21)[2021-03-15]. http://hbj.nanjing.gov.cn/njshjbhj/201810/t20181020_459954.html.Nanjing Ecological Environment Bureau. Nanjing "13th Five-Year" Ecological Environment Protection Plan[EB/OL]. (2017-06-21)[2021-03-15]. http://hbj.nanjing.gov.cn/njshjbhj/201810/t20181020_459954.html. [11] 薛涛, 刘俊, 张强, 等. 2013~2017年中国PM2.5污染的快速改善及其健康效益[J]. 中国科学: 地球科学, 2020, 50(4): 441-452. DOI: 10.1360/SSTe-2019-0245.Xue T, Liu J, Zhang Q, et al. Rapid improvement of PM2.5 pollution and associated health benefits in China during 2013-2017[J]. Scientia Sinica Terrae, 2020, 50(4): 441-452. DOI: 10.1360/SSTe-2019-0245. [12] 胡辛楠, 王荀, 徐新云, 等. 深圳和太原PM2.5金属元素分析与致癌风险评价[J]. 中华疾病控制杂志, 2019, 23(11): 1420-1424. DOI: 10.16462/j.cnki.zhjbkz.2019.11.024.Hu XN, Wang X, Xu XY, et al. Metal elements analysis and risk assessment of carcinogenicity on PM2.5 samples collected from Shenzhen and Taiyuan[J]. Chin J Dis Control Prev, 2019, 23(11): 1420-1424. DOI: 10.16462/j.cnki.zhjbkz.2019.11.024. [13] 熊丽林. PM2.5诱导的炎性反应对心血管内皮的损伤及分子机制研究[D]. 南京: 东南大学, 2019.Xiong LL. Research of Injury and molecular mechanism of inflammatory response lnduced by PM2.5 on cardiovascular endothelium[D]. Nanjing: Southeast University, 2019. [14] 陈鑫, 王临池, 郭倩岚, 等. 苏州市大气PM2.5浓度与心脑血管疾病死亡的时间序列分析[J]. 中华疾病控制杂志, 2019, 23(6): 661-666. DOI: 10.16462/j.cnki.zhjbkz.2019.06.009.Chen X, Wang LC, Guo QL, et al. Association between PM2.5 pollution in ambient air and cardio-cerebrovascular mortality in Suzhou in 2016: a time series analysis[J]. Chin J Dis Control Prev, 2019, 23(6): 661-666. DOI: 10.16462/j.cnki.zhjbkz.2019.06.009. [15] Pini L, Giordani J, Gardini G, et al. Emergency department admission and hospitalization for COPD exacerbation and particulate matter short-term exposure in Brescia, a highly polluted town in northern Italy[J]. Respir Med, 2021, 179: 106334. DOI: 10.1016/j.rmed.2021.106334. [16] 陈琦, 孙宏, 陈晓东, 等. 南京市臭氧短期暴露人群急性健康效应研究[J]. 江苏预防医学, 2017, 28(4): 366-368. DOI: 10.13668/j.issn.1006-9070.2017.04.02.Chen Q, Sun H, Chen XD, et al. Acute health impacts of ozone exposure on daily mortality in Nanjing[J]. Jiangsu J Prev Med, 2017, 28(4): 366-368. DOI: 10.13668/j.issn.1006-9070.2017.04.02. [17] Yang G, Wang Y, Zeng Y, et al. Rapid health transition in China, 1990-2010: findings from the Global Burden of Disease Study 2010[J]. Lancet, 2013, 381(9882): 1987-2015. DOI: 10.1016/S0140-6736(13)61097-1. [18] Bowe B, Xie Y, Yan Y, et al. Burden of cause-specific mortality associated with PM2.5 air pollution in the United States[J]. JAMA Network Open, 2019, 2(11): e1915834. DOI: 10.1001/jamanetworkopen.2019.15834. [19] Burnett R, Chen H, Szyszkowicz M, et al. Global estimates of mortality associated with long term exposure to outdoor fine particulate matter[J]. Proc Natl Acad Sci U S A, 2018, 115(38): 9592-9597. DOI: 10.1073/pnas.1803222115. [20] 陈菁, 彭金龙, 徐彦森. 北京市2014~2020年PM2.5和O3时空分布与健康效应评估[J]. 环境科学, 2021, 42(9): 4071-4082.Chen J, Peng JL, Xu YS. Spatiotemporal distribution and health effects of PM2.5 and O3 in Beijing from 2014 to 2020[J/OL]. Environmental Science, 2021, 42(9): 4071-4082. [21] 崔永学, 彭秀苗, 曹萌, 等. 济南市在全国大气污染治理行动中的长期健康收益[J]. 环境卫生学杂志, 2019, 9(5): 467-471. DOI: 10.13421/j.cnki.hjwsxzz.2019.05.011.Cui YX, Peng XM, Cao M, et al. Long-term health benefits of Jinan City during National Air Pollution Control Action[J]. J Environ Hygiene, 2019, 9(5): 467-471. DOI: 10.13421/j.cnki.hjwsxzz.2019.05.011. [22] 南京市生态环境局. 南京市大气污染防治条例[EB/OL]. (2019-01-25)[2021-03-15]. http://hbj.nanjing.gov.cn/zwgk/flfg/201901/t20190125_1386220.html.Nanjing Ecological Environment Bureau. Nanjing Air Pollution Control Regulations[EB/OL]. (2019-01-25)[2021-03-15]. http://hbj.nanjing.gov.cn/zwgk/flfg/201901/t20190125_1386220.html.