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浙江省台州市老年HIV感染者流感疫苗接种及抗体阳性率分析

李仕祯,  翁坚,  靳妍,  梁鸿镖,  汪剡灵,  沈伟伟,  胡雅飞,  林海江,  何纳,  陈潇潇

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文章导航 > 中华疾病控制杂志  > 2021 >  25(12): 1431-1435
李仕祯, 翁坚, 靳妍, 梁鸿镖, 汪剡灵, 沈伟伟, 胡雅飞, 林海江, 何纳, 陈潇潇. 浙江省台州市老年HIV感染者流感疫苗接种及抗体阳性率分析[J]. 中华疾病控制杂志, 2021, 25(12): 1431-1435. doi: 10.16462/j.cnki.zhjbkz.2021.12.013
引用本文: 李仕祯, 翁坚, 靳妍, 梁鸿镖, 汪剡灵, 沈伟伟, 胡雅飞, 林海江, 何纳, 陈潇潇. 浙江省台州市老年HIV感染者流感疫苗接种及抗体阳性率分析[J]. 中华疾病控制杂志, 2021, 25(12): 1431-1435. doi: 10.16462/j.cnki.zhjbkz.2021.12.013
shu
LI Shi-zhen, WENG Jian, JIN Yan, LIANG Hong-biao, WANG Shan-ling, SHEN Wei-wei, HU Ya-fei, LIN Hai-jiang, HE Na, CHEN Xiao-xiao. Influenza vaccination and seroepidemiological status in elderly HIV-infected patients in Taizhou, Zhejiang Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(12): 1431-1435. doi: 10.16462/j.cnki.zhjbkz.2021.12.013
Citation: LI Shi-zhen, WENG Jian, JIN Yan, LIANG Hong-biao, WANG Shan-ling, SHEN Wei-wei, HU Ya-fei, LIN Hai-jiang, HE Na, CHEN Xiao-xiao. Influenza vaccination and seroepidemiological status in elderly HIV-infected patients in Taizhou, Zhejiang Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(12): 1431-1435. doi: 10.16462/j.cnki.zhjbkz.2021.12.013
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浙江省台州市老年HIV感染者流感疫苗接种及抗体阳性率分析

doi: 10.16462/j.cnki.zhjbkz.2021.12.013
  • 1.

    200032 上海，复旦大学公共卫生学院流行病学教研室，公共卫生安全教育部重点实验室

  • 2.

    318000 台州，台州市疾病预防控制中心重点疾病防制科

基金项目: 

上海市公共卫生三年行动计划流行病学重点学科建设项目 GWV-10.1-XK-16

浙江省自然科学基金 LY19H260001

详细信息
    通讯作者:

    陈潇潇，E-mail：tzcdcxx@126.com

  • 中图分类号: R181; R512.91

Influenza vaccination and seroepidemiological status in elderly HIV-infected patients in Taizhou, Zhejiang Province

  • 1.

    Department of Public Health Epidemiology, Fudan University, Key Laboratory of Public Health and Safety Education, Shanghai 200032, China

  • 2.

    Department of Key Disease Prevention and Control, Taizhou Center for Disease Control and Prevention, Taizhou 318000, China

Funds: 

Shanghai Municipal Health Commission GWV-10.1-XK-16

Natural Science Basic Research Program of Zhejiang Province LY19H260001

More Information

    摘要
  • 摘要:   目的  对浙江省台州市2018―2019年老年HIV感染者流感疫苗接种特征及流感抗体阳性率进行分析。  方法  运用描述性流行病学方法，分析老年HIV感染者接种流感疫苗现状及接种疫苗后抗体水平，并应用Logistic回归分析模型进行影响因素分析。  结果  本研究共纳入台州市≥60岁HIV感染者749人，2018―2019年流感疫苗接种率为33.9%，其中2018年和2019年流感疫苗接种率分别为22.3%和23.6%，持续接种率为12.0%。老年HIV感染者的流感疫苗接种率在不同职业中差异有统计学意义(P < 0.001)。浙江省台州市老年HIV感染者年龄70~80岁(OR=1.84; 95% CI: 1.32~2.58)、职业为农民(OR=3.89; 95% CI: 1.69~8.98)是疫苗接种的影响因素。本研究老年HIV感染者的流感抗免疫球蛋白G(immunoglobulin G, IgG)的血清阳性率分别为21.2%(甲型H1N1流感)、18.1%(甲型H3N2流感)、8.8%(乙型流感)。  结论  浙江省台州市老年HIV感染者流感疫苗接种率与其年龄和职业存在关联，疫苗接种效果评价仍需要更多证据的支持。
    Abstract:   Objective  To elucidate the characteristics and influencing factors of influenza vaccination among elderly people infected with HIV and the positive rate of influenza antibodies from 2018 to 2019.  Methods  Epidemiological methods of description were used to analyze the current status of influenza vaccination and post-vaccination antibody levels in elderly HIV-infected patients, and Logistic regression models were applied to analyze the influencing factors.  Results  A total of 749 HIV-infected people over 60 years old in Taizhou were included in this study. The influenza vaccination rate from 2018 to 2019 was 33.9%, of which the vaccination rate in 2018 and 2019 was 22.3% and 23.6%, respectively, and the continuous vaccination rate was 12.0%. There were differences in age, occupation and education level among the elderly HIV-infected people with different vaccination choices. Age 70-80 years old (OR=1.84; 95% CI: 1.32-2.58), farmer (OR=3.89; 95% CI: 1.69-8.98) were factors influencing vaccination rates. In addition, the serological positive rates of influenza antibody immunoglobulin G (IgG) in elderly HIV-infected patients were 21.2% (Influenza A H1N1), 18.1% (Influenza A H3N2) and 8.8% (Influenza B).  Conclusions  Influenza vaccination rates among elderly HIV-infected patients in Taizhou, Zhejiang Province, were significantly associated with their age and occupation. More evidence is needed to evaluate the efficacy of vaccination.
    • HTML全文

  • 表  1  2018―2019年台州市老年HIV感染者流感疫苗接种情况[n(%)]

    Table  1.   Influenza vaccination in the elderly infected with HIV in Taizhou from 2018 to 2019 [n(%)]

    变量 接种率(%) 合计 接种组 未接种组
    年龄(岁)
        60~ < 70 28.9 439(58.6) 127(50.0) 312(63.0)
        70~ < 80 42.4 257(34.3) 109(42.9) 148(29.9)
        ≥80 34.0 53(7.1) 18(7.1) 35(7.1)
    性别
        男 33.5 571(76.2) 191(75.2) 380(76.8)
        女 35.4 178(23.8) 63(24.8) 115(23.2)
    职业
        单位退休人员 15.2 46(6.1) 7(2.8) 39(7.9)
        农民 38.9 525(70.1) 204(80.3) 321(64.8)
        其他 24.2 178(23.8) 43(16.9) 135(27.3)
    文化程度
        小学及以下 36.4 552(73.7) 201(79.1) 351(70.9)
        初中 29.3 150(20.0) 44(17.3) 106(21.4)
        中专及以上 19.1 47(6.3) 9(3.5) 38(7.7)
    婚姻
        已婚有配偶 36.5 485(64.8) 177(69.7) 308(62.2)
        未婚 15.0 20(2.7) 3(1.2) 17(3.4)
        离婚或丧偶 30.3 244(32.6) 74(29.1) 170(34.3)
    感染途径
        异性传播 34.5 658(87.9) 227(89.4) 431(87.1)
        同性传播 29.1 79(10.5) 23(9.1) 56(11.3)
        血液传播及其他 44.4 12(1.6) 4(1.6) 8(1.6)
    性病史
        有 33.3 96(12.8) 32(12.6) 64(12.9)
        无/不详 36.9 601(80.2) 222(87.4) 431(87.1)
    CD4+T淋巴细胞水平(个/μl)
        0~ < 200 30.8 120(16) 37(14.6) 83(16.8)
        200~ < 350 35.3 224(29.9) 79(31.1) 145(29.3)
        350~ < 500 31.0 213(28.4) 66(26.0) 147(29.7)
        ≥500 37.5 192(25.6) 72(28.3) 120(24.2)
    下载: 导出CSV

    表  2  台州市老年HIV感染者疫苗接种影响因素分析

    Table  2.   Analysis of factors influencing vaccination of elderly HIV-infected patients in Taizhou City

    变量 接种率(%) 单因素分析 多因素分析
    OR(95% CI)值 P值 OR(95% CI)值 P值
    年龄(岁)
        60~ < 70 28.9 1.00
        70~ < 80 42.4 1.81(1.31~2.5) 0.017 1.84(1.32~2.58) 0.037
        ≥80 34.0 1.26(0.69~2.31) 0.835 1.45(0.77~2.73) 0.832
    性别
        男 33.5 1.00
        女 35.4 1.09(0.77~1.55) 0.633 1.13(0.78~1.63) 0.526
    职业
        单位退休人员 15.2 1.00
        农民 38.9 3.54(1.55~8.07) < 0.001 3.89(1.69~8.98) < 0.001
        其他 24.2 1.77(0.74~4.26) 0.830 2.10(0.86~5.14) 0.822
    文化程度
        小学及以下 36.4 1.00
        初中 29.3 0.73(0.49~1.07) 0.647
        中专及以上 19.1 0.41(0.2~0.87) 0.060
    婚姻
        已婚有配偶 36.5 1.00
        未婚 15.0 0.31(0.09~1.06) 0.099 0.32(0.09~1.14) 0.127
        离婚或丧偶 30.3 0.76(0.55~1.05) 0.366 0.74(0.52~1.04) 0.465
    感染途径
        异性传播 34.5 1.00
        同性传播 29.1 0.78(0.47~1.30) 0.574
        血液传播及其他 44.4 0.95(0.28~3.19) 0.908
    性病史
        有 33.3 1.00
        无/不详 36.9 1.03(0.65~1.62) 0.898
    CD4+T淋巴细胞水平(个/μl)
        0~ < 200 30.8 1.00
        200~ < 350 35.3 1.22(0.76~1.96) 0.589
        350~ < 500 31.0 1.01(0.62~1.63) 0.367
        ≥500 37.5 1.35(0.83~2.19) 0.197
    下载: 导出CSV

    表  3  2020年台州市老年HIV感染者随访血清流感抗体IgG阳性率[n(%)]

    Table  3.   Serum IgG positive rate of influenza antibody in elderly HIV-infected patients in follow-up visits in Taizhou City in 2020 [n(%)]

    变量 合计 接种组 未接种组 χ2值 P值
    甲型H1N1流感病毒 96(21.2) 35(21.0) 61(21.3) 0.01 0.926
    甲型H3N2流感病毒 82(18.1) 34(20.4) 48(16.8) 0.91 0.340
    乙型流感病毒 40(8.8) 13(7.8) 27(9.4) 0.36 0.549
    下载: 导出CSV
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  • 收稿日期:  2021-02-04
  • 修回日期:  2021-05-24
  • 网络出版日期:  2021-12-27
  • 刊出日期:  2021-12-10

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