贵州省布依族蛋类摄入与心血管疾病的剂量-反应关系

王乔荣; 刘磊磊; 马娜娜; 徐子轩; 彭莲; 张林源; 洪峰

doi:10.16462/j.cnki.zhjbkz.2022.06.007

贵州省布依族蛋类摄入与心血管疾病的剂量-反应关系

doi: 10.16462/j.cnki.zhjbkz.2022.06.007

1.
550025 贵阳，贵州医科大学大学城医院
2.
550025 贵阳，贵州医科大学公共卫生与健康学院，环境污染与疾病监控教育部重点实验室

基金项目:

国家重点研发计划课题 2017YFC0907301

详细信息

通讯作者:
洪峰，E-mail: fhong@gmc.edu.cn

中图分类号: R195.4;R181.3
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- 被引次数: 0
出版历程
- 收稿日期: 2021-08-12
- 修回日期: 2022-01-18
- 网络出版日期: 2022-06-16
- 刊出日期: 2022-06-10

A preliminary study on the dose-response relationship between egg consumption and cardiovascular diseases in the Bouyei ethnic group of Guizhou Province

1.
The Higher Education Mega Center Hospital, Guizhou Medical University, Guiyang 550025, China
2.
School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 550025, China

Funds:

The National Key R&D Program of China 2017YFC0907301

More Information

Corresponding author: HONG Feng, E-mail: fhong@gmc.edu.cn

摘要

摘要: 目的评估贵州省布依族蛋类摄入与心血管疾病患病风险之间的剂量-反应关系。方法基于"中国多民族队列研究"的横断面调查数据, 共纳入5 908名贵州省布依族30~79岁成年人。基于2010年中国人口普查数据计算心血管疾病的年龄标化患病率。基于多因素Logistic回归分析模型, 采用限制性立方样条模型分析剂量-反应关系。结果心血管疾病的年龄标化患病率为3.19%。蛋类每周摄入次数和摄入量与心血管疾病患病风险之间均存在非线性的剂量-反应关系(P_非线性 < 0.001), 且每周蛋类摄入次数在7次以下、摄入量在500 g以下时心血管疾病患病风险较低。当蛋类每周摄入次数在4次以上7次以下、摄入量在200 g以上500 g以下时, 心血管疾病患病风险可降低60%左右。结论贵州省布依族成年人蛋类摄入与心血管疾病之间存在非线性剂量-反应关系, 适量的蛋类摄入可能对心血管疾病有保护作用。
- 蛋类 /
- 心血管疾病 /
- 剂量-反应关系 /
- 少数民族 /
- 危险因素
Abstract: Objective The study aimed to evaluate the potential dose-response relationship between egg consumption and the risk of cardiovascular diseases among the Bouyei ethnic group in Guizhou Province. Methods Based on the China Multi-Ethnic Cohort Study, a cross-sectional assessment was conducted among 5 908 Bouyei adults aged 30-79 years from Guizhou Province. The age-standardized prevalence of cardiovascular diseases was calculated according to 2010 China Census data. A restricted cubic splines model based on a multivariable Logistic regression model was applied to assess the dose-response association. Results The age-standardized prevalence of cardiovascular diseases was 3.19%. There was a non-linear dose-response association between the frequency and amount of egg intake per week and the risk of cardiovascular diseases risk (P_nonlinearity < 0.001). Moreover, lower cardiovascular diseases risk was identified when the frequency of eggs consumed per week was less than 7 times and the intake was less than 500 grams. Our results also indicated that the risk of cardiovascular diseases can be decreased by 60% when the frequency of eggs consumed per week was between 4 and 7 times and the intake was between 200 and 500 grams. Conclusion A non-linear dose-response association of egg consumption with cardiovascular diseases was observed among Bouyei adults in Guizhou Province. These findings suggest that keeping optimal egg consumption may have a protective effect on cardiovascular diseases.
- Egg /
- Cardiovascular diseases /
- Dose-response association /
- Ethnic group /
- Risk factor

HTML全文

图 1 蛋类每周摄入次数与心血管疾病的剂量-反应关系

(A，未调整模型；B，调整年龄和性别；C，调整表 1中P＜0.05的协变量；D，全部调整模型)

Figure 1. Dose-response association between the times of egg consumption and cardiovascular diseases

(A, unadjusted model; B, adjusted age and sex; C, adjusted covariates P < 0.05 in Table 1; D, multi-adjusted model)

下载: 全尺寸图片幻灯片

图 2 蛋类每周摄入量与心血管疾病的剂量-反应关系

(A，未调整模型；B，调整年龄和性别；C，调整表 1中P＜0.05的协变量；D，全部调整模型)

Figure 2. Dose-response association between the intakes of egg consumption and cardiovascular diseases

(A, unadjusted model; B, adjusted age and sex; C, adjusted covariates P < 0.05 in Table 1; D, multi-adjusted model)

下载: 全尺寸图片幻灯片

表 1 研究对象基本特征

Table 1. Baseline characteristics of participants

变量	非心血管疾病组	心血管疾病组	χ²/Z值	P值	变量	非心血管疾病组	心血管疾病组	χ²/Z值	P值
人数	5 685	223			总体力活动(代谢当量-h/d)	23.80(13.14~37.10)	13.86(6.10~28.21)	-7.000	＜0.001
年龄(岁)	50.99(43.93~59.01)	60.38(53.02~66.96)	10.520	＜0.001	新鲜蔬菜	5 661(99.86)	221(99.55)	1.340	0.247
性别			15.080	＜0.001	新鲜水果	5 307(93.63)	209(94.14)	0.090	0.758
男性	1 726(30.36)	95(42.60)			乳类及制品(如牛奶、酸奶)	2 448(43.19)	103(46.40)	0.890	0.344
女性	3 959(69.64)	128(57.40)			总能量摄入(千卡/周)	10.64(8.15~13.81)	9.91(7.44~12.94)	-2.810	0.005
吸烟状态			0.240	0.624	BMI(kg/m²)	23.83(21.58~26.24)	24.97(22.34~27.05)	4.080	＜0.001
不吸烟	4 691(82.54)	179(80.27)			高血压	822(14.47)	117(52.47)	231.650	＜0.001
已戒烟	167(2.94)	22(9.87)			糖尿病	144(2.53)	25(11.21)	58.100	＜0.001
目前吸烟	825(14.52)	22(9.87)			高脂血症	121(2.13)	28(12.56)	94.830	＜0.001
每周饮酒			0.800	0.372	心血管疾病家族史	225(3.96)	10(4.48)	0.160	0.693
是	5 515(97.01)	214(95.96)
否	170(2.99)	9(4.04)
注：连续型变量用[M(P₂₅, P₇₅)]表示；分类变量用频数[n(%)]表示；P值为非心血管疾病组和心血管疾病组的组间比较。

下载: 导出CSV

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