A preliminary study on the dose-response relationship between egg consumption and cardiovascular diseases in the Bouyei ethnic group of Guizhou Province
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摘要:
目的 评估贵州省布依族蛋类摄入与心血管疾病患病风险之间的剂量-反应关系。 方法 基于"中国多民族队列研究"的横断面调查数据, 共纳入5 908名贵州省布依族30~79岁成年人。基于2010年中国人口普查数据计算心血管疾病的年龄标化患病率。基于多因素Logistic回归分析模型, 采用限制性立方样条模型分析剂量-反应关系。 结果 心血管疾病的年龄标化患病率为3.19%。蛋类每周摄入次数和摄入量与心血管疾病患病风险之间均存在非线性的剂量-反应关系(P非线性 < 0.001), 且每周蛋类摄入次数在7次以下、摄入量在500 g以下时心血管疾病患病风险较低。当蛋类每周摄入次数在4次以上7次以下、摄入量在200 g以上500 g以下时, 心血管疾病患病风险可降低60%左右。 结论 贵州省布依族成年人蛋类摄入与心血管疾病之间存在非线性剂量-反应关系, 适量的蛋类摄入可能对心血管疾病有保护作用。 Abstract:Objective The study aimed to evaluate the potential dose-response relationship between egg consumption and the risk of cardiovascular diseases among the Bouyei ethnic group in Guizhou Province. Methods Based on the China Multi-Ethnic Cohort Study, a cross-sectional assessment was conducted among 5 908 Bouyei adults aged 30-79 years from Guizhou Province. The age-standardized prevalence of cardiovascular diseases was calculated according to 2010 China Census data. A restricted cubic splines model based on a multivariable Logistic regression model was applied to assess the dose-response association. Results The age-standardized prevalence of cardiovascular diseases was 3.19%. There was a non-linear dose-response association between the frequency and amount of egg intake per week and the risk of cardiovascular diseases risk (Pnonlinearity < 0.001). Moreover, lower cardiovascular diseases risk was identified when the frequency of eggs consumed per week was less than 7 times and the intake was less than 500 grams. Our results also indicated that the risk of cardiovascular diseases can be decreased by 60% when the frequency of eggs consumed per week was between 4 and 7 times and the intake was between 200 and 500 grams. Conclusion A non-linear dose-response association of egg consumption with cardiovascular diseases was observed among Bouyei adults in Guizhou Province. These findings suggest that keeping optimal egg consumption may have a protective effect on cardiovascular diseases. -
Key words:
- Egg /
- Cardiovascular diseases /
- Dose-response association /
- Ethnic group /
- Risk factor
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表 1 研究对象基本特征
Table 1. Baseline characteristics of participants
变量 非心血管疾病组 心血管疾病组 χ2/Z值 P值 变量 非心血管疾病组 心血管疾病组 χ2/Z值 P值 人数 5 685 223 总体力活动(代谢当量-h/d) 23.80(13.14~37.10) 13.86(6.10~28.21) -7.000 <0.001 年龄(岁) 50.99(43.93~59.01) 60.38(53.02~66.96) 10.520 <0.001 新鲜蔬菜 5 661(99.86) 221(99.55) 1.340 0.247 性别 15.080 <0.001 新鲜水果 5 307(93.63) 209(94.14) 0.090 0.758 男性 1 726(30.36) 95(42.60) 乳类及制品(如牛奶、酸奶) 2 448(43.19) 103(46.40) 0.890 0.344 女性 3 959(69.64) 128(57.40) 总能量摄入(千卡/周) 10.64(8.15~13.81) 9.91(7.44~12.94) -2.810 0.005 吸烟状态 0.240 0.624 BMI(kg/m2) 23.83(21.58~26.24) 24.97(22.34~27.05) 4.080 <0.001 不吸烟 4 691(82.54) 179(80.27) 高血压 822(14.47) 117(52.47) 231.650 <0.001 已戒烟 167(2.94) 22(9.87) 糖尿病 144(2.53) 25(11.21) 58.100 <0.001 目前吸烟 825(14.52) 22(9.87) 高脂血症 121(2.13) 28(12.56) 94.830 <0.001 每周饮酒 0.800 0.372 心血管疾病家族史 225(3.96) 10(4.48) 0.160 0.693 是 5 515(97.01) 214(95.96) 否 170(2.99) 9(4.04) 注:连续型变量用[M(P25, P75)]表示;分类变量用频数[n(%)]表示;P值为非心血管疾病组和心血管疾病组的组间比较。 -
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