Epidemiological characteristics of high-risk population of cardiovascular disease in residents aged 35-75 years in Hunan Province
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摘要:
目的 了解湖南省35~75岁居民心血管病高危人群流行病学特征,为心血管病防治提供依据。 方法 利用湖南省心血管病高危人群早期筛查与综合干预项目数据分析心血管病高危人群流行病学特征,通过拟合多变量混合效应模型来评估个体特征与心血管病高危风险之间的关联。 结果 共纳入99 001名调查对象,平均年龄(56.6±9.7)岁,62.2%为女性。心血管病高危人群占比12.1%,高危人群中有96.4%患有高血压。生活在农村(r=0.036)、民族为汉族(r=0.012)、饮酒(r=0.041)、超重(r=0.110)和肥胖(r=0.086)都与心血管病高危风险呈正相关,而高学历(r=-0.040)、高家庭收入(r=-0.032)和已婚(r=-0.027)与心血管病高危风险呈负相关(均有P < 0.001)。 结论 湖南省筛查出心血管病高危人群的比例较高,应重点针对其采取健康教育和综合干预措施,以减少全省居民心血管病发病风险。 Abstract:Objective To understand epidemiological characteristics of high-risk population of cardiovascular disease in adults aged 35-75 years in Hunan Province, and to provide basis for prevention and treatment of cardiovascular diseases. Methods Epidemiological characteristics of high-risk population of cardiovascular disease were analyzed through the data from China Patient-Centered Evaluative Assessment of Cardiac Events (PEACE) Million Persons Project in Hunan Province. The mixed model was used to analyze the association between individual characteristics and high risk of cardiovascular disease. Results Totally, 99 001 participants were enrolled in this study, with an average age of (56.6±9.7) years. In both sexes, 62.2 % of participants were females and 37.8% were males. 12.1% of the participants were the high-risk population for cardiovascular diseases, and among these high-risk population, 96.4% people had been diagnosed with hypertension. Living in rural areas, Han nationality, drinkers and overweight/obesity were positively correlated with the risk of cardiovascular disease, while those with high education, high family income and married were negatively correlated with the risk of cardiovascular disease (all P < 0.001). Conclusions The proportion of high-risk population of cardiovascular disease screened in Hunan Province is high. Comprehensive intervention measures should be taken to reduce the risk of cardiovascular disease among high-risk population. -
Key words:
- Cardiovascular disease /
- High-risk population /
- Epidemic characteristics
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表 1 不同特征人群心血管病高危情况
Table 1. Characteristics of persons with high cardiovascular disease risk
特征 调查人数[n(%)] 高危人数(n) 高危检出率(%) χ2值 P值 合计 99 001(100.0) 11 954 12.1 性别 2 391.382 <0.001 男 37 448(37.8) 6 953 18.6 女 61 553(62.2) 5 001 8.1 年龄(岁) 9 925.700 <0.001 35~<40 4 393(4.4) 0 0.0 40~<45 7 716(7.8) 97 1.3 45~<50 13 256(13.4) 241 1.8 50~<55 18 802(19.0) 851 4.5 55~<60 12 677(12.8) 759 6.0 60~<65 16 774(16.9) 3 111 18.5 65~<70 15 898(16.1) 3 342 21.0 70~75 9 485(9.6) 3 553 37.5 城乡 409.967 <0.001 农村 77 540(78.3) 10 218 13.2 城市 21 461(21.7) 1 736 8.1 民族 88.506 <0.001 汉族 89 965(90.9) 11 067 12.3 非汉族 8 400(8.5) 774 9.2 不清楚 636(0.6) 113 17.8 教育程度 1 206.625 <0.001 小学及以下 54 399(54.9) 8 416 15.5 初中 28 485(28.8) 2 445 8.6 高中 11 784(11.9) 920 7.8 大学及以上 4 221(4.3) 156 3.7 不清楚 112(0.1) 17 15.2 职业 535.717 <0.001 农民 60 125(60.7) 8 416 14.0 非农民 37 997(38.4) 3 443 9.1 不清楚 879(0.9) 95 10.8 家庭年收入(元) 520.030 <0.001 < 10 000 12 008(12.1) 2 342 19.5 10 000~50 000 60 516(61.1) 7 192 11.9 >50 000 21 168(21.4) 1 779 8.4 不清楚 5 309(5.4) 641 12.1 婚姻状况 356.017 <0.001 已婚 90 987(91.9) 10 471 11.5 未婚 7 776(7.9) 1 459 18.8 不清楚 238(0.2) 24 10.1 医疗保险情况 0.469 0.791 无医疗保险 300(0.3) 40 13.3 有医疗保险 98 532(99.5) 11 893 12.1 不清楚 169(0.2) 21 12.4 BMI(kg/m2) 366.599 <0.001 低 22 638(22.9) 274 11.0 正常 8 236(8.3) 4 887 10.2 超重 46 230(46.7) 4 866 13.4 肥胖 13 736(13.9) 1 927 15.6 表 2 个体特征与心血管病高危相关情况
Table 2. The characteristics of participants and their correlations with cardiovascular diseases
特征 男性 女性 合计 OR(95% CI)值 P值 OR(95% CI)值 P值 OR(95% CI)值 P值 城乡 城市 1.00 1.00 1.00 农村 1.45(1.34~1.58) < 0.001 1.39(1.26~1.52) < 0.001 1.46(1.37~1.55) < 0.001 民族 非汉族 1.00 1.00 1.00 汉族 1.49(1.33~1.66) < 0.001 1.87(1.65~2.12) < 0.001 1.63(1.50~1.77) < 0.001 教育程度 小学及以下 1.00 1.00 1.00 初中 0.54(0.50~0.58) < 0.001 0.52(0.47~0.56) < 0.001 0.57(0.54~0.60) < 0.001 高中 0.52(0.47~0.58) < 0.001 0.47(0.40~0.54) < 0.001 0.57(0.53~0.62) < 0.001 大学及以上 0.26(0.21~0.31) < 0.001 0.13(0.08~0.19) < 0.001 0.27(0.23~0.32) < 0.001 职业 非农民 1.00 1.00 1.00 农民 0.91(0.84~0.98) 0.014 0.92(0.85~0.99) 0.043 0.97(0.92~1.03) 0.347 家庭年收入(元) < 10 000 1.00 1.00 1.00 10 000~50 000 0.65(0.60~0.70) < 0.001 0.66(0.61~0.72) < 0.001 0.67(0.63~0.71) < 0.001 >50 000 0.53(0.47~0.58) < 0.001 0.56(0.50~0.62) < 0.001 0.56(0.52~0.60) < 0.001 婚姻状况 未婚 1.00 1.00 1.00 已婚 0.77(0.69~0.85) < 0.001 0.55(0.51~0.60) < 0.001 0.69(0.64~0.73) < 0.001 医疗保险情况 无医疗保险 1.00 1.00 1.00 有医疗保险 1.08(0.67~1.74) 0.763 1.00(0.57~1.75) 0.995 1.04(0.72~1.48) 0.849 饮酒 无 1.00 1.00 1.00 有 1.72(1.61~1.84) < 0.001 1.30(1.03~1.64) 0.025 2.70(2.54~2.86) < 0.001 BMI(kg/m2) 正常 1.00 1.00 1.00 超重 1.29(1.21~1.37) < 0.001 1.56(1.45~1.67) < 0.001 1.38(1.32~1.45) < 0.001 肥胖 1.53(1.41~1.67) < 0.001 1.97(1.81~2.15) < 0.001 1.66(1.56~1.76) < 0.001 -
[1] 中国心血管健康与疾病报告编写组. 中国心血管健康与疾病报告2019概要[J]. 中国循环杂志, 2020, 35(9): 833-854. DOI: 10.3969/j.issn.1000-3614.2020.09.001.The Writing Committee of the Report on Cardiovascular Health and Diseases in China. Report on cardiovascular health and diseases in China 2019: an updated summary[J]. Chinese Circulation Journal, 2020, 35(9): 833-854. DOI: 10.3969/j.issn.1000-3614.2020.09.001. [2] Lu J, Xuan S, Downing N S, et al. Protocol for the China PEACE (Patient-centered Evaluative Assessment of Cardiac Events) Million Persons Project pilot[J]. BMJ Open, 2016, 6(1): e10200. DOI: 10.1136/bmjopen-2013-004595. [3] 中国心血管病预防指南(2017)写作组, 中华心血管病杂志编辑委员会. 中国心血管病预防指南(2017)[J]. 中华心血管病杂志, 2018, 46(1): 10-25. DOI: 10.3760/cma.j.issn.0253-3758.2018.01.004.Chinese cardiovascular disease prevention guidelines writing group(2017), Editorial board of Chinese Journal of cardiovascular disease. Guidelines for prevention of cardiovascular diseases in China[J]. Chin J Cardiol, 2018, 46(1): 10-25. DOI: 10.3760/cma.j.issn.0253-3758.2018.01.004. [4] World Health Organization. Prevention of cardiovascular disease: guidelines for assessment and management of cardiovascular risk[M]. Geneva: World Health Organization, 2007. [5] 2010 Chinese guidelines for the management of hypertension Writing group. 2010 Chinese guidelines for the management of hypertension[J]. Chin J Cardiol, 2011, 39(7): 579-616. DOI: 10.3760/cma.j.issn.0253-3758.2011.07.002. [6] 中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2013年版)[J]. 中国糖尿病杂志, 2014, 22(8): 2-42. DOI: 10.3760/cma.j.issn.1674-5809.2014.07.004.Chinese diabetes society. Guidelines for the prevention and treatment of type 2 diabetes in China[J]. Chin J Diabetes Mellitus, 2014, 22(8): 2-42. DOI: 10.3760/cma.j.issn.1674-5809.2014.07.004. [7] Lu J, Lu Y, Yang H, et al. Characteristics of high cardiovascular risk in 1.7 million chinese adults[J]. Ann Intern Med, 2019, 170(5): 298-308. DOI: 10.7326/M18-1932. [8] 黄裕立. 高血压前期和心脑肾血管风险相关性的研究[D]. 广州: 南方医科大学, 2014.Huang YL. The association of cardiovascular and Renal risk with prehypertension[D]. Guangzhou: Southern Medical University, 2014. [9] Ettehad D, Emdin CA, Kiran A, et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis[J]. Lancet, 2016, 387(10022): 957-967. DOI: 10.1016/S0140-6736(15)01225-8.