广州市一起由新型冠状病毒Delta变异株引起的家庭聚集性疫情流行病学调查

何时雨; 苗宇田; 韩志刚; 罗业飞; 蔡衍珊; 马蒙蒙; 陈远源; 陈宗遒; 袁俊; 古羽舟

doi:10.16462/j.cnki.zhjbkz.2023.03.016

广州市一起由新型冠状病毒Delta变异株引起的家庭聚集性疫情流行病学调查

doi: 10.16462/j.cnki.zhjbkz.2023.03.016

何时雨^{1, 7},
苗宇田^{2, 7},
韩志刚^{3, 7},
罗业飞^{3, 7},
蔡衍珊^{3, 7},
马蒙蒙^{4, 7},
陈远源^{5, 7},
陈宗遒^{1, 7},
袁俊^{6, 7},
古羽舟^{3, 7, ,}

1.
510440 广州，广州市疾病预防控制中心消毒杀虫部
2.
510440 广州，广州市疾病预防控制中心环境卫生部
3.
510440 广州，广州市疾病预防控制中心艾滋病预防控制部
4.
510440 广州，广州市疾病预防控制中心传染病预防控制部
5.
510440 广州，广州市疾病预防控制中心慢性非传染性疾病预防控制部
6.
510440 广州，广州市疾病预防控制中心主任室
7.
510440 广州，广州市疾病预防控制中心广州医科大学公共卫生研究院

何时雨和苗宇田为共同第一作者

基金项目:

广州市医学重点学科建设项目 2021-2023-11

广州市医学重点学科建设项目 2021-2023-12

广州市重点实验室基础研究计划项目 2021BRP004

详细信息

通讯作者:
古羽舟，E-mail：yuchoukoo@foxmail.com

中图分类号: R184.6
计量
- 文章访问数: 295
- HTML全文浏览量: 150
- PDF下载量: 21
- 被引次数: 0
出版历程
- 收稿日期: 2021-10-08
- 修回日期: 2022-01-25
- 网络出版日期: 2023-04-04
- 刊出日期: 2023-03-10

Epidemiological investigation of a family clustering of COVID-19 caused by SARS-CoV-2 Delta variant in Guangzhou, China

HE Shi-yu^{1, 7},
MIAO Yu-tian^{2, 7},
HAN Zhi-gang^{3, 7},
LUO Ye-fei^{3, 7},
CAI Yan-shan^{3, 7},
MA Meng-meng^{4, 7},
CHEN Yuan-yuan^{5, 7},
CHEN Zong-qiu^{1, 7},
YUAN Jun^{6, 7},
GU Yu-zhou^{3, 7
, ,}

1.
Department of Disinfection and Vector Control, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
2.
Department of Environmental Health, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
3.
Department of AIDS Control and Prevention, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
4.
Department of Communicable Disease Control and Prevention, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
5.
Department of Chronic Non-communicable Disease Control and Prevention, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
6.
Department of Center Director, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
7.
Institute of Public Health, Guangzhou Medical University & Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China

HE Shi-yu and MIAO Yu-tian contributed equally to this article

Funds:

The Key Project of Medicine Discipline of Guangzhou 2021-2023-11

The Key Project of Medicine Discipline of Guangzhou 2021-2023-12

Basic Research Project of Key Laboratory of Guangzhou 2021BRP004

More Information

Corresponding author: GU Yu-zhou, E-mail: yuchoukoo@foxmail.com

摘要

摘要: 目的分析广州市一起由Delta变异株(B.1.617.2)引起的COVID-19家庭聚集性疫情的流行病学特征，为相关疫情防控提供参考。方法从中国疾病预防控制中心传染病报告管理信息系统和流行病学调查资料获取病例信息，采用描述性流行病学方法对该起疫情的调查和特征进行分析描述。结果该起家庭聚集性疫情涉及6名确诊病例，其中男、女各3人，中位年龄为24.50岁，均无新型冠状病毒(简称新冠)疫苗接种史。病例1~4与确诊病例在某餐厅有同时段用餐史，在暴露后4~7 d陆续发病；家庭成员病例5、6则分别在病例1~4发病后2~5 d发病。除病例1、2是由社区集中核酸检测发现，其余4人均是作为病例1、2的密切接触者在集中隔离观察中检测发现。6名病例活动轨迹累计涉及24个重点场所，共甄别密切接触者427人，除病例3~6外无续发感染。结论结合疫苗接种和非药物类控制措施，重点关注和控制家庭聚集性发病，仍是阻断COVID-19疫情社区传播的重要策略。
- 新型冠状病毒肺炎 /
- 新型冠状病毒Delta变异株 /
- 家庭聚集性 /
- 流行病学调查
Abstract: Objective To investigate the epidemiological characteristics of a family clustering of COVID-19 caused by SARS-CoV-2 Delta (B.1.617.2) variant in Guangzhou, China. Methods The information of this case were extracted from Chinese CDC Infectious Disease Information System and epidemiological investigation. Demographic and epidemiological characteristics of this case were analyzed and described through descriptive epidemiological analysis. Results This family clustering included 6 cases, 3 of them were male, and the median age was 24.50 years. None of them accepted vaccination. 4 cases (case 1-4) of them developed symptoms successively 4-7 d after they had an exposure history in a restaurant with a confirmed case. Due to close contact, the other two family members (case 5, 6) developed symptoms 2-5 d after the onset of the 4 cases aforementioned. Case 1 and 2 were found after taking the centralized nucleic acid testing of SARS-CoV-2 in the community, case 3-6 were reported during the centralized health observation as the close contacts of case 1 and 2. A total of 24 key locations were involved in the activity trajectories of the 6 cases, and 427 close contacts were found. Except for other 4 cases, none of the close contacts were infected. Conclusions With vaccination and non-pharmaceutical interventions, focusing on stopping transmitting in family is still an important and useful strategy in preventing and controlling the community transmission of COVID-19 epidemic.
- COVID-19 /
- SARS-CoV-2 Delta variant /
- Family clustering /
- Epidemiological investigation

HTML全文

图 1 病例发病和报告时序图

Figure 1. Chronlogy of case onset and reporting

下载: 全尺寸图片幻灯片

图 2 病例传播关系图

Figure 2. Transmission relationship among the cases

下载: 全尺寸图片幻灯片

表 1 病例基本信息和临床特征

Table 1. Information and clinical characteristics of the cases

变量	病例1	病例2	病例3	病例4	病例5	病例6
年龄(岁)	51	58	24	22	21	25
性别	女	男	男	女	女	男
职业	无业	无业	电子商务	学生	学生	电子商务
病史	高血压	无	无	无	无	无
新冠疫苗接种史	无	无	无	无	无	无
发病日期	5月29日	5月31日	6月1日	5月30日	6月3日	6月3日
临床症状
发热	无	无	有	有	有	无
干咳	无	有	有	无	无	无
咳痰	有	无	无	无	无	无
头痛	无	有	有	无	无	有
肌肉疼痛	无	无	有	有	无	有
乏力	无	无	有	无	无	有
白细胞数量	无异常	升高	无异常	无异常	无异常	无异常
淋巴细胞数量	降低	无异常	无异常	降低	降低	无异常
淋巴细胞比例	降低	无异常	无异常	降低	降低	无异常
嗜中性粒细胞数量	无异常	升高	无异常	无异常	无异常	无异常
嗜中性粒细胞比例	升高	无异常	无异常	无异常	无异常	无异常
胸部CT扫描	双肺多发炎症，以双肺下叶为著	双肺多发炎症	右肺下叶小斑片状稍高密度影，虑局灶性炎症	无异常	无异常	左肺上叶前段胸膜下见小斑片状稍高密度影
首次核酸阳性采样日期	5月30日	5月30日	6月1日	6月1日	6月2日	6月3日
入院及报告日期	6月1日	6月1日	6月3日	6月3日	6月3日	6月4日
临床分型	重型	普通型	普通型	普通型	轻型	普通型
出院日期	6月21日	6月25日	6月24日	6月24日	6月26日	6月23日

下载: 导出CSV

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