北京市人群骨退行性疾病患病及影响因素

王超; 王倩倩; 张砚卓; 陶剑锋; 王莹; 肖斌; 姜旭; 吴成爱

doi:10.16462/j.cnki.zhjbkz.2023.07.014

北京市人群骨退行性疾病患病及影响因素

doi: 10.16462/j.cnki.zhjbkz.2023.07.014

王超¹,
王倩倩¹,
张砚卓¹,
陶剑锋¹,
王莹¹,
肖斌²,
姜旭³,
吴成爱^1, ,

1.
首都医科大学附属北京积水潭医院，北京市创伤骨科研究所，国家骨科医学中心，北京 100035
2.
首都医科大学附属北京积水潭医院，脊柱外科，北京 100035
3.
首都医科大学附属北京积水潭医院，矫形骨科，北京 100035

基金项目:

北京市优秀人才培养资助青年骨干个人 2015000021469G178

北京市卫生健康委-改革与发展专项 BJRITO-RDP-2023

国家科技部，十二五支撑计划课题 2012BAI10B02

北京积水潭医院青年人才培养学科新星计划 XKXX201801

详细信息

通讯作者:
吴成爱，E-mail: wuchengai@jst-hosp.com.cn

中图分类号: R181.3
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出版历程
- 收稿日期: 2023-04-17
- 修回日期: 2023-07-11
- 网络出版日期: 2023-08-08
- 刊出日期: 2023-07-10

Prevalence and associated factors of bone degenerative diseases among Beijing residents

1.
National Center for Orthopaedics, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China
2.
Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China
3.
Department of Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China

Funds:

Beijing Talents Fund 2015000021469G178

Beijing Municipal Health Commission BJRITO-RDP-2023

Key Projects in the National Science & Technology Pillar Program during the Twelfth Five-year Plan Period 2012BAI10B02

Beijing Jishuitan Hospital Nova XKXX201801

More Information

Corresponding author: WU Chengai, E-mail: wuchengai@jst-hosp.com.cn

摘要

摘要: 目的在北京市人群中开展骨退行性疾病(bone degenerative diseases, BDD)研究, 以了解北京市BDD人群患病情况及影响因素。方法采用方便抽样, 招募自愿参与且年龄在18~ < 65岁的北京市常住人群进入北京BDD研究。采用问卷收集受试者的一般人口学资料, 同时对受试者进行体格检查、生化检查和骨科专科体检, 并开展影像学检查。运用多因素logistic回归模型分析BDD影响因素。结果共纳入879名研究对象, 年龄为(39.79±9.12)岁。共有697人患有BDD, 占总人数79.29%。多因素logistic回归模型分析显示, 高龄人群患BDD的风险较高。与18~ < 35岁组相比, 35~ < 50岁组与50~ < 65岁组BDD患病的OR值(95% CI)分别为2.684(1.845~3.904)与13.898(4.807~40.176)。超重和肥胖者与体质指数(body mass index, BMI)正常者相比, OR值(95% CI)分别为1.209(0.811~1.801)和1.768(1.030~3.035)。已婚者患病风险显著高于未婚/离异/丧偶者, 其OR值(95% CI)为1.924(1.271~2.912)。结论北京市18~ < 65岁人群BDD检出率较高。应加强在已婚、高年龄段、超重和肥胖者中BDD的宣传及体检。
- 横断面研究 /
- 流行病学研究设计 /
- 骨退行性疾病 /
- 膝骨关节炎 /
- 颈腰椎退行性疾病
Abstract: Objective The Beijing bone degenerative diseases (BDD) study aims to investigate the prevalence and factors associated with BDD among the population in the Beijing area. Methods We recruited the volunteers aged 18- < 65 years who were residents of Beijing using convenience sampling.Participants completed a questionnaire about demographic information, and underwent physical, biochemical examinations, orthopedic examinations and imagological examination.Multivariate logistic regression was used to identify the influencing factors associated with BDD. Results A total of 879 participants with an average age of (39.79±9.12) years were included in the BDD study.A total of 697 subjects had BDD, accounting for 79.29% of the whole participants.Multivariate logistic regression analysis showed that the risk of bone degenerative diseases was higher in older age groups.Compared to the 18- < 35 age group, the OR value (95% CI) for BDD were 2.684(1.845-3.904) for the 35- < 50 age group, and 13.898(4.807-40.176) for the 50- < 65 age group.The OR value (95% CI) of BDD in overweight and obesity participants, compared to normal BMI, were 1.209(0.811-1.801) and 1.768(1.030-3.035), respectively.Married participants had a significantly higher risk of BDD than unmarried/divorced/widowed participants, with an OR value (95% CI): 1.924(1.271-2.912). Conclusions The prevalence of BDD among Beijing residents aged 18- < 65 years is much higher.The promotion and physical examination of BDD should be strengthened for married, elderly, overweight and obese people.
- Cross-sectional study /
- Design of epidemiological study /
- Bone degenerative diseases /
- Knee osteoarthritis /
- Degenerative diseases of the cervical and lumbar spine

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表 1 研究对象BDD的单因素分析

Table 1. Univariate analysis of BDD among subjects

特征 Feature	合计(n=879) Total (n=879)	有BDD ^① (n=697) Subjects with BDD (n=697)	无BDD ^① (n=182) Subjects without BDD (n=182)	t/χ²值 t/χ² value	P值 P value
年龄组/岁, (x±s) Age group/years, (x±s)		41.34±8.82	33.86±7.73	-10.440	< 0.001
18~＜35	306	195(63.73)	111(36.27)	77.400	< 0.001
35~＜50	449	382(85.08) ^②	67(14.92)	74.510 ^③	< 0.001
50~＜65	124	120(96.77) ^②④	4(3.23)
性别 Sex
男 Male	379	307(81.00)	72(19.00)	1.184	0.277
女 Female	500	390(78.00)	110(22.00)
受教育程度/% Education level/%
初中及以下 Middle school or below	72	65(90.28)	7(9.72)	9.651	0.022
高中 Higher school	117	99(84.62)	18(15.38)	7.402 ^③	0.007
大专或本科 College or associates degree	530	407(76.79) ^②	123(23.21)
研究生及以上 Post-graduate or above	148	114(77.03)	34(22.97)
婚姻状况/% Marital status/%
未婚/离异/丧偶 Unmarried/Divorced/ Widowed	145	91(62.76)	54(37.24)	28.920	< 0.001
已婚 Married	734	606(82.56)	128(17.44)
吸烟/% Smoking status/%
否 No	674	524(77.74)	150(22.26)	3.157	0.076
是 Yes	190	159(83.68)	31(16.32)
饮酒/% Alcohol/%
否 No	539	422(78.29)	117(21.71)	0.497	0.481
是 Yes	325	261(80.31)	64(19.69)
BMI/(kg·m^-2)
< 24	389	291(74.81)	98(25.19)	10.003	0.007
24~ < 28	314	255(81.21)	59(18.79)	9.896 ^③	0.002
≥28	176	151(85.80) ^②	25(14.20)
高血压/% Hypertension/%
否 No	715	550(76.92)	165(23.08)	13.128	< 0.001
是 Yes	164	147(89.63)	17(10.37)
血脂异常/% Dyslipidemia/%
否 No	615	473(76.91)	142(23.09)	6.836	0.009
是 Yes	262	222(84.73)	40(15.27)
BDD家族史/% Family history of BDD/%
否 No	603	478(79.27)	125(20.73)	< 0.001	0.979
是 Yes	276	219(79.35)	57(20.65)
注：BDD，骨退行性疾病; BMI, 体质指数。 ①以[人数(占比/%)]表示。②与该指标第一分类差异有统计学意义(P < 0.017)。③趋势χ²检验。④与该指标第二分类差异有统计学意义(P < 0.017)。 Note: BDD, bone degenerative diseases; BMI, body mass index. ① [Number of people (proportion/%)]. ② There was a statistically significant difference with the first classification of the index (P < 0.017). ③ Chi-square test of trend. ④ There was a statistically significant difference with the second classification of the index (P < 0.017).

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表 2 影响BDD的多因素logistic回归分析模型

Table 2. Multivariable logistic regression analysis model of influencing factors for BDD

变量 Variable	β值 β value	Wald值 Wald value	OR值(95% CI) OR value(95% CI)	P值 P value
年龄组/岁 Age group/years
18~＜35			1.000
35~＜50	0.987	26.687	2.684(1.845~3.904)	< 0.001
50~＜65	2.632	23.610	13.898(4.807~40.176)	< 0.001
受教育程度 Education level
初中及以下 Middle school or below			1.000
高中 Higher school	-0.390	0.626	0.677(0.257~1.780)	0.429
大专或本科 College or associates degree	-0.283	0.425	0.754(0.322~1.763)	0.514
研究生及以上 Post-graduate or above	-0.240	0.261	0.787(0.314~1.973)	0.609
婚姻状况 Marital status
未婚/离异/丧偶 Unmarried/Divorced/ Widowed			1.000
已婚 Married	0.654	9.578	1.924(1.271~2.912)	0.002
BMI/(kg·m^-2)
< 24			1.000
24~ < 28	0.190	0.869	1.209(0.811~1.801)	0.351
≥28	0.570	4.279	1.768(1.030~3.035)	0.039
高血压 Hypertension
否 No			1.000
是 Yes	0.257	0.717	1.293(0.713~2.345)	0.397
血脂异常 Dyslipidemia
否 No			1.000
是 Yes	0.055	0.058	1.056(0.677~1.647)	0.810
注：BDD，骨退行性疾病; BMI, 体质指数。 Note: BDD, bone degenerative diseases; BMI, body mass index.

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特征 Feature	合计(n=879) Total (n=879)	有BDD ^① (n=697) Subjects with BDD (n=697)	无BDD ^① (n=182) Subjects without BDD (n=182)	t/χ²值 t/χ² value	P值 P value
年龄组/岁, (x±s) Age group/years, (x±s)		41.34±8.82	33.86±7.73	-10.440	< 0.001
18~＜35	306	195(63.73)	111(36.27)	77.400	< 0.001
35~＜50	449	382(85.08) ^②	67(14.92)	74.510 ^③	< 0.001
50~＜65	124	120(96.77) ^②④	4(3.23)
性别 Sex
男 Male	379	307(81.00)	72(19.00)	1.184	0.277
女 Female	500	390(78.00)	110(22.00)
受教育程度/% Education level/%
初中及以下 Middle school or below	72	65(90.28)	7(9.72)	9.651	0.022
高中 Higher school	117	99(84.62)	18(15.38)	7.402 ^③	0.007
大专或本科 College or associates degree	530	407(76.79) ^②	123(23.21)
研究生及以上 Post-graduate or above	148	114(77.03)	34(22.97)
婚姻状况/% Marital status/%
未婚/离异/丧偶 Unmarried/Divorced/ Widowed	145	91(62.76)	54(37.24)	28.920	< 0.001
已婚 Married	734	606(82.56)	128(17.44)
吸烟/% Smoking status/%
否 No	674	524(77.74)	150(22.26)	3.157	0.076
是 Yes	190	159(83.68)	31(16.32)
饮酒/% Alcohol/%
否 No	539	422(78.29)	117(21.71)	0.497	0.481
是 Yes	325	261(80.31)	64(19.69)
BMI/(kg·m^-2)
< 24	389	291(74.81)	98(25.19)	10.003	0.007
24~ < 28	314	255(81.21)	59(18.79)	9.896 ^③	0.002
≥28	176	151(85.80) ^②	25(14.20)
高血压/% Hypertension/%
否 No	715	550(76.92)	165(23.08)	13.128	< 0.001
是 Yes	164	147(89.63)	17(10.37)
血脂异常/% Dyslipidemia/%
否 No	615	473(76.91)	142(23.09)	6.836	0.009
是 Yes	262	222(84.73)	40(15.27)
BDD家族史/% Family history of BDD/%
否 No	603	478(79.27)	125(20.73)	< 0.001	0.979
是 Yes	276	219(79.35)	57(20.65)
注：BDD，骨退行性疾病; BMI, 体质指数。 ①以[人数(占比/%)]表示。②与该指标第一分类差异有统计学意义(P < 0.017)。③趋势χ²检验。④与该指标第二分类差异有统计学意义(P < 0.017)。 Note: BDD, bone degenerative diseases; BMI, body mass index. ① [Number of people (proportion/%)]. ② There was a statistically significant difference with the first classification of the index (P < 0.017). ③ Chi-square test of trend. ④ There was a statistically significant difference with the second classification of the index (P < 0.017).

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北京市人群骨退行性疾病患病及影响因素

doi: 10.16462/j.cnki.zhjbkz.2023.07.014

通讯作者:
吴成爱，E-mail: wuchengai@jst-hosp.com.cn

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Prevalence and associated factors of bone degenerative diseases among Beijing residents

Corresponding author: WU Chengai, E-mail: wuchengai@jst-hosp.com.cn

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留言板

北京市人群骨退行性疾病患病及影响因素

doi: 10.16462/j.cnki.zhjbkz.2023.07.014

通讯作者: 吴成爱，E-mail: wuchengai@jst-hosp.com.cn

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出版历程

Prevalence and associated factors of bone degenerative diseases among Beijing residents

Corresponding author: WU Chengai, E-mail: wuchengai@jst-hosp.com.cn

计量

出版历程

目录

通讯作者:
吴成爱，E-mail: wuchengai@jst-hosp.com.cn