Prevalence and associated factors of bone degenerative diseases among Beijing residents
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摘要:
目的 在北京市人群中开展骨退行性疾病(bone degenerative diseases, BDD)研究, 以了解北京市BDD人群患病情况及影响因素。 方法 采用方便抽样, 招募自愿参与且年龄在18~ < 65岁的北京市常住人群进入北京BDD研究。采用问卷收集受试者的一般人口学资料, 同时对受试者进行体格检查、生化检查和骨科专科体检, 并开展影像学检查。运用多因素logistic回归模型分析BDD影响因素。 结果 共纳入879名研究对象, 年龄为(39.79±9.12)岁。共有697人患有BDD, 占总人数79.29%。多因素logistic回归模型分析显示, 高龄人群患BDD的风险较高。与18~ < 35岁组相比, 35~ < 50岁组与50~ < 65岁组BDD患病的OR值(95% CI)分别为2.684(1.845~3.904)与13.898(4.807~40.176)。超重和肥胖者与体质指数(body mass index, BMI)正常者相比, OR值(95% CI)分别为1.209(0.811~1.801)和1.768(1.030~3.035)。已婚者患病风险显著高于未婚/离异/丧偶者, 其OR值(95% CI)为1.924(1.271~2.912)。 结论 北京市18~ < 65岁人群BDD检出率较高。应加强在已婚、高年龄段、超重和肥胖者中BDD的宣传及体检。 Abstract:Objective The Beijing bone degenerative diseases (BDD) study aims to investigate the prevalence and factors associated with BDD among the population in the Beijing area. Methods We recruited the volunteers aged 18- < 65 years who were residents of Beijing using convenience sampling.Participants completed a questionnaire about demographic information, and underwent physical, biochemical examinations, orthopedic examinations and imagological examination.Multivariate logistic regression was used to identify the influencing factors associated with BDD. Results A total of 879 participants with an average age of (39.79±9.12) years were included in the BDD study.A total of 697 subjects had BDD, accounting for 79.29% of the whole participants.Multivariate logistic regression analysis showed that the risk of bone degenerative diseases was higher in older age groups.Compared to the 18- < 35 age group, the OR value (95% CI) for BDD were 2.684(1.845-3.904) for the 35- < 50 age group, and 13.898(4.807-40.176) for the 50- < 65 age group.The OR value (95% CI) of BDD in overweight and obesity participants, compared to normal BMI, were 1.209(0.811-1.801) and 1.768(1.030-3.035), respectively.Married participants had a significantly higher risk of BDD than unmarried/divorced/widowed participants, with an OR value (95% CI): 1.924(1.271-2.912). Conclusions The prevalence of BDD among Beijing residents aged 18- < 65 years is much higher.The promotion and physical examination of BDD should be strengthened for married, elderly, overweight and obese people. -
表 1 研究对象BDD的单因素分析
Table 1. Univariate analysis of BDD among subjects
特征 Feature 合计(n=879)
Total (n=879)有BDD ① (n=697)
Subjects with BDD (n=697)无BDD ① (n=182)
Subjects without BDD (n=182)t/χ2值
t/χ2 valueP值
P value年龄组/岁, (x±s) Age group/years, (x±s) 41.34±8.82 33.86±7.73 -10.440 < 0.001 18~＜35 306 195(63.73) 111(36.27) 77.400 < 0.001 35~＜50 449 382(85.08) ② 67(14.92) 74.510 ③ < 0.001 50~＜65 124 120(96.77) ②④ 4(3.23) 性别 Sex 男 Male 379 307(81.00) 72(19.00) 1.184 0.277 女 Female 500 390(78.00) 110(22.00) 受教育程度/% Education level/% 初中及以下 Middle school or below 72 65(90.28) 7(9.72) 9.651 0.022 高中 Higher school 117 99(84.62) 18(15.38) 7.402 ③ 0.007 大专或本科 College or associates degree 530 407(76.79) ② 123(23.21) 研究生及以上 Post-graduate or above 148 114(77.03) 34(22.97) 婚姻状况/% Marital status/% 未婚/离异/丧偶 Unmarried/Divorced/ Widowed 145 91(62.76) 54(37.24) 28.920 < 0.001 已婚 Married 734 606(82.56) 128(17.44) 吸烟/% Smoking status/% 否 No 674 524(77.74) 150(22.26) 3.157 0.076 是 Yes 190 159(83.68) 31(16.32) 饮酒/% Alcohol/% 否 No 539 422(78.29) 117(21.71) 0.497 0.481 是 Yes 325 261(80.31) 64(19.69) BMI/(kg·m-2) < 24 389 291(74.81) 98(25.19) 10.003 0.007 24~ < 28 314 255(81.21) 59(18.79) 9.896 ③ 0.002 ≥28 176 151(85.80) ② 25(14.20) 高血压/% Hypertension/% 否 No 715 550(76.92) 165(23.08) 13.128 < 0.001 是 Yes 164 147(89.63) 17(10.37) 血脂异常/% Dyslipidemia/% 否 No 615 473(76.91) 142(23.09) 6.836 0.009 是 Yes 262 222(84.73) 40(15.27) BDD家族史/% Family history of BDD/% 否 No 603 478(79.27) 125(20.73) < 0.001 0.979 是 Yes 276 219(79.35) 57(20.65) 注：BDD，骨退行性疾病; BMI, 体质指数。
①以[人数(占比/%)]表示。②与该指标第一分类差异有统计学意义(P < 0.017)。③趋势χ2检验。④与该指标第二分类差异有统计学意义(P < 0.017)。
Note: BDD, bone degenerative diseases; BMI, body mass index.
① [Number of people (proportion/%)]. ② There was a statistically significant difference with the first classification of the index (P < 0.017). ③ Chi-square test of trend. ④ There was a statistically significant difference with the second classification of the index (P < 0.017).
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表 2 影响BDD的多因素logistic回归分析模型
Table 2. Multivariable logistic regression analysis model of influencing factors for BDD
变量
Variableβ值
β valueWald值
Wald valueOR值(95% CI)
OR value(95% CI)P值
P value年龄组/岁 Age group/years 18~＜35 1.000 35~＜50 0.987 26.687 2.684(1.845~3.904) < 0.001 50~＜65 2.632 23.610 13.898(4.807~40.176) < 0.001 受教育程度 Education level 初中及以下 Middle school or below 1.000 高中 Higher school -0.390 0.626 0.677(0.257~1.780) 0.429 大专或本科 College or associates degree -0.283 0.425 0.754(0.322~1.763) 0.514 研究生及以上 Post-graduate or above -0.240 0.261 0.787(0.314~1.973) 0.609 婚姻状况 Marital status 未婚/离异/丧偶 Unmarried/Divorced/ Widowed 1.000 已婚 Married 0.654 9.578 1.924(1.271~2.912) 0.002 BMI/(kg·m-2) < 24 1.000 24~ < 28 0.190 0.869 1.209(0.811~1.801) 0.351 ≥28 0.570 4.279 1.768(1.030~3.035) 0.039 高血压 Hypertension 否 No 1.000 是 Yes 0.257 0.717 1.293(0.713~2.345) 0.397 血脂异常 Dyslipidemia 否 No 1.000 是 Yes 0.055 0.058 1.056(0.677~1.647) 0.810 注：BDD，骨退行性疾病; BMI, 体质指数。
Note: BDD, bone degenerative diseases; BMI, body mass index.
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