Survey on hepatitis C infection among hospital patients in some counties and districts of Anhui Province
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摘要:
目的 了解安徽省医院就诊人群丙型病毒性肝炎(丙肝)感染状况及特征。 方法 采用分层随机抽样方法，选择安徽省6个县市区作为研究现场，采用连续抽样的方法，对调查期间符合纳入标准的就诊人群进行调查和HCV抗体、核酸检测。 结果 共调查7 052例医院就诊人群，HCV抗体阳性率为0.68%，核酸阳性率为0.31%。综合医院就诊人群HCV抗体阳性率高于妇幼保健院(P=0.004)，不同性别间HCV抗体和核酸阳性率差异均无统计学意义(均P>0.05)。不同年龄段间HCV抗体和核酸阳性率差异均有统计学意义(均P < 0.001)，其中≥20岁人群HCV抗体和核酸阳性率均随年龄增长而升高。不同科室送检的血样HCV抗体和核酸阳性率差异均有统计学意义(均P < 0.001)。 结论 安徽省医院就诊人群丙肝感染状况呈中等流行水平，应加强对感染/传染科、内镜室等重点科室就诊人群的丙肝筛查。 Abstract:Objective To understand the infection status and characteristics of hepatitis C infections among patients in various hospitals across Anhui. Methods We employed stratified random sampling to select patients from six counties or districts in Anhui Province. Patients meeting the inclusion criteria during the survey period were continuously sampled and tested for both HCV antibody and HCV RNA. Results A total of 7 052 cases were investigated, with a positive rate of 0.68% for HCV antibody and 0.31% for HCV RNA. The positive rate of HCV antibody in general hospitals was significantly higher than that in maternal and child health care hospitals, and the difference was statistically significant (P=0.004). There was no statistically significant difference in the positive rates of HCV antibody and HCV RNA between different genders (all P>0.05). The differences in the positive rates of HCV antibody and HCV RNA among different age groups was statistically significant (all P < 0.001), among which the positive rates of HCV antibody and HCV RNA in all age groups of respondents over 20 years old increased with age. The difference in blood-like HCV antibody and HCV RNA positive rates sent for examination from different departments were statistically significant (all P < 0.001). Conclusions The infection status of hepatitis C in Anhui provincial hospital patients is moderately prevalent, and the screening of hepatitis C for patients in key departments such as infection departments and endoscopic departments should be strengthened. -
Key words:
- Hepatitis C /
- Infection rate /
- Cross-sectional Survey
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表 1 医院就诊人群HCV抗体和HCV核酸阳性率分布情况
Table 1. The distribution situation of HCV antibody and HCV RNA positive rate among hospital patients
变量Variable 调查人数
NumberHCV抗体阳性人数
Number of people with HCV antibodyHCV抗体阳性率/%
Positive rate of HCV antibody/%核酸阳性人数
Number of people with positive HCV RNA核酸阳性率/%
Positive rate of HCV RNA/%年龄组/岁Age group/years 1~＜5 489 0 0 0 0 5~＜10 485 0 0 0 0 10~＜15 450 0 0 0 0 15~＜20 401 0 0 0 0 20~＜25 390 1 0.26 1 0.26 25~＜30 431 1 0.23 0 0 30~＜35 557 1 0.18 0 0 35~＜40 525 1 0.19 1 0.19 40~＜45 557 5 0.90 2 0.36 45~＜50 558 6 1.08 0 0 50~＜55 570 10 1.75 8 1.40 55~＜60 546 11 2.01 5 0.92 60~＜65 545 4 0.73 2 0.37 65~＜70 548 8 1.46 3 0.55 送检科室The department for blood testing 感染/传染科Infectious diseases department 115 10 8.70 7 6.09 消化科Gastroenterology 164 1 0.61 0 0 内科Internal medicine 928 10 1.08 6 0.65 外科Surgery 1 592 11 0.69 4 0.25 妇产科Obstetricsand gynecology 836 4 0.48 1 0.12 儿科Pediatrics 1 124 0 0 0 0 五官科Pentaphthaliaceae 372 2 0.54 0 0 皮肤性病科Dermatology department 70 0 0 0 0 急诊科Emergency department 33 0 0 0 0 重症监护室Intensive care unit 22 0 0 0 0 医疗整容美容科Medical plastic surgery and beauty department 17 0 0 0 0 内镜室Endoscopy department 49 1 2.04 1 2.04 其他Other 1 730 9 0.52 3 0.17 送检原因Reasons for blood testing 输血/血制品Blood transfusion/Blood products 175 3 1.71 2 1.14 手术前检查Preoperative examination 1 591 10 0.63 4 0.25 口腔诊疗Oral diagnosis and treatment 4 0 0 0 0 医疗美容整容Aesthetic medicine plastic surgery 16 0 0 0 0 内窥镜检查Endoscopy testing 165 1 0.61 1 0.61 孕检/产检Pregnancy/prenatal examination 211 0 0 0 0 侵入性诊疗Invasive diagnosis and treatment 327 2 0.61 有肝病临床症状Clinical symptoms of liver disease 48 1 2.08 1 2.08 有流行病学暴露史Have a history of epidemiological exposure 281 0 0 0 0 体检Physical examination 2 161 9 0.42 4 0.19 其他Other 2 073 22 1.06 10 0.48 
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