吉林省德惠市40岁及以上人群高TG血症-腰围表型与心血管危险因素聚集的关系

任远; 邱子涵; 张付良; 郭珍妮; 张鹏; 孙欣; 靳航; 李凤娥

doi:10.16462/j.cnki.zhjbkz.2023.08.016

吉林省德惠市40岁及以上人群高TG血症-腰围表型与心血管危险因素聚集的关系

doi: 10.16462/j.cnki.zhjbkz.2023.08.016

任远¹,
邱子涵¹,
张付良²,
郭珍妮²,
张鹏²,
孙欣²,
靳航²,
李凤娥^3, ,

1.
北华大学临床医学院研究生部，吉林 132013
2.
吉林大学第一医院神经内科，长春 130061
3.
北华大学附属医院神经内科，吉林 132011

基金项目:

国家卫生和计划生育委员会脑卒中高危人群筛查和干预项目 GN-2016R0010

吉林省教育厅科学技术研究项目 JJKH20210064KJ

详细信息

通讯作者:
李凤娥，E-mail: 1059250609@qq.com

中图分类号: R181.2
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出版历程
- 收稿日期: 2021-11-05
- 修回日期: 2022-04-08
- 网络出版日期: 2023-09-02
- 刊出日期: 2023-08-10

Relationship between hypertriglyceridemic-waist phenotype and clustering of cardiovascular risk factors among residents aged 40 and above in Dehui City, Jilin Province

1.
Department of Postgraduate Students, Clinical Medical College of Beihua University, Jilin 132013, China
2.
Department of Neurology, The First Hospital of Jilin University, Changchun 130061, China
3.
Department of Neurology, The Affiliated Hospital of Beihua University, Jilin 132011, China

Funds:

Project on research and application of effective intervention techniques for high risk population of stroke from the National Health and Family Planning Commission in China GN-2016R0010

Science and technology research project of the Education Department of Jilin Province JJKH20210064KJ

More Information

Corresponding author: LI Feng′e, E-mail: 1059250609@qq.com

摘要

摘要: 目的探讨吉林省德惠市≥40岁人群高三酰甘油血症-腰围表型(hypertriglyceridemic-waist phenotype, HTWP)与心血管危险因素(cardiovascular risk factors, CRFs)聚集的关系。方法采用多阶段分层随机整群抽样方法于2016年1―3月对吉林省德惠市≥40岁人群进行横断面调查。将HTWP定义为空腹血清三酰甘油(triglyceride, TG)≥1.7 mmol/L，男性腰围(waist circumference, WC)≥90 cm或女性WC≥80 cm。采用logistic回归分析模型评估该人群HTWP与CRFs聚集的相关性。结果吉林省德惠市40岁及以上人群HTWP检出率为33.98%。HTWP组和正常腰围-正常三酰甘油(normal waist-normal triglycerides, NWNT)组CRFs聚集检出率分别为71.68%和20.90%。多因素logistic回归分析模型分析结果显示HTWP组CRFs聚集检出风险为NWNT组的12.01倍(OR=12.01, 95% CI: 9.83~14.67, P < 0.001)。结论 HTWP与CRFs聚集密切相关，可用于≥40岁人群CRFs聚集的筛查。
- 高三酰甘油血症 /
- 腰围 /
- 心血管危险因素 /
- 横断面研究
Abstract: Objective This study aimed to explore the relationship between hypertriglyceridemic-waist phenotype (HTWP) and clustering of cardiovascular risk factors (CRFs) among residents aged 40 and above in Dehui City, Jilin Province. Methods A cross-sectional survey was conducted among residents aged 40 and above in Dehui City, Jilin Province, from January to March 2016, using a multistage stratified, random cluster sampling method. The HTWP was defined by serum triglyceride (TG) levels of ≥1.7 mmol/L and waist circumference (WC) of ≥90 cm in males or ≥80 cm in females. The logistic regression model was conducted to assess the relationship between the HTWP and the clustering of CRFs. Results The prevalence of HTWP was 33.98% among residents aged 40 and above in Dehui City, Jilin Province. The detection rates of CRFs clustering in the HTWP group and normal waist-normal triglycerides (NWNT) group were 71.68% and 20.90%, respectively. The multivariate logistic regression analysis indicated that the risk of detecting CRFs clustering in the HTWP group was 12.01 times greater than that in the NWNT group (OR=12.01, 95% CI: 9.83-14.67, P < 0.001). Conclusions The HTWP is strongly correlated with the clustering of CRFs, making it a convenient tool for screening CRFs clustering in residents aged 40 and above.
- Hypertriglyceridemia /
- Waist circumference /
- Cardiovascular risk factors /
- Cross-sectional study

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表 1 四组的基线特征

Table 1. Baseline characteristics of four groups

组别Group	NWNT(n=1 115)[人数(占比/%)] NWNT (n=1 115)[Number of people(proportion/%)]	NWET(n=462)[人数(占比/%)] NWET (n=462)[Number of people(proportion/%)]	EWNT(n=1 098)[人数(占比/%)] EWNT (n=1 098)[Number of people(proportion/%)]	HTWP(n=1 377)[人数(占比/%)] HTWP (n=1 377)[Number of people(proportion/%)]	H/χ²值value	P值value
年龄/岁, M(IQR) Age/years, M(IQR)	52(14.00)	50(12.00)	55(15.00) ^①	56(14.00) ^①	107.64	< 0.001
性别Sex					182.28	< 0.001
男Male	567(50.85)	265(57.36)	345(31.42) ^①	442(32.10) ^①	―
女Female	548(49.15)	197(42.64)	753(68.58) ^①	935(67.90) ^①	―
居住地Residence					29.53	< 0.001
城市Urban	576(51.66)	273(59.09) ^①	494(44.99) ^①	724(52.58)	―
农村Rural	539(48.34)	189(40.91) ^①	604(55.01) ^①	653(47.42)	―
受教育程度Education					31.94	< 0.001
高中及以下High school and below	825(73.99)	327(70.78)	886(80.69) ^①	1 104(80.17) ^①	―
高中以上Above high school	290(26.01)	135(29.22)	212(19.31) ^①	273(19.83) ^①	―
体力活动Physical activities	909(81.52)	344(74.46) ^①	875(79.69)	1 022(74.22) ^①	29.31	< 0.001
高血压Hypertension	428(38.39)	234(50.65) ^①	624(56.83) ^①	921(66.88) ^①	207.07	< 0.001
糖尿病Diabetes	31(2.78)	27(5.84) ^①	71(6.47) ^①	201(14.60) ^①	126.93	< 0.001
吸烟Smoking	308(27.62)	150(32.47)	415(37.80) ^①	500(36.31) ^①	31.04	< 0.001
饮酒Drinking	331(29.69	176(38.10) ^①	247(22.50) ^①	320(23.24) ^①	54.25	< 0.001
SBP/mmHg, M(IQR)	130.50(25.00)	134.00(26.60) ^①	138.75(28.10) ^①	145.00(28.50) ^①	274.35	< 0.001
DBP/mmHg, M(IQR)	84.00(14.00)	87.00(16.00) ^①	88.00(14.50) ^①	90.50(16.00) ^①	195.17	< 0.001
BMI/(kg·m^-2), M(IQR)	21.83(3.14)	22.89(3.43) ^①	25.20(3.91) ^①	26.23(3.90) ^①	1 446.68	< 0.001
WC/cm, M(IQR)	77(9.00)	79(10.00) ^①	90(10.00) ^①	90(10.00) ^①	2 008.39	< 0.001
FPG/(mmol·L^-1), M(IQR)	4.80(0.90)	4.90(1.00)	4.90(1.03) ^①	5.10(1.40) ^①	119.15	< 0.001
TG/(mmol·L^-1), M(IQR)	1.10(0.47)	2.32(1.18) ^①	1.25(0.48) ^①	2.56(1.45) ^①	2 965.31	< 0.001
TC/(mmol·L^-1), M(IQR)	4.99(1.29)	5.52(1.43) ^①	5.23(1.32) ^①	5.63(1.40) ^①	270.07	< 0.001
HDL-C/(mmol·L^-1), M(IQR)	1.27(0.26)	1.20(0.22) ^①	1.26(0.25)	1.20(0.24) ^①	190.30	< 0.001
LDL-C/(mmol·L^-1), M(IQR)	1.79(1.31)	1.87(1.14)	1.88(1.10)	1.96(1.07) ^①	22.01	< 0.001
注：1. HTWP：正常腰围-正常三酰甘油；NWET：单纯高三酰甘油；EWNT：单纯腹型肥胖；HTWP：高三酰甘油血症-腰围表型；SBP, 收缩压；DBP：舒张压；BMI：体质指数；FPG：空腹血糖；TG：三酰甘油；TC：总胆固醇；HDL-C：高密度脂蛋白胆固醇。LDL-C：低密度脂蛋白胆固醇； 2. “―”表示模型未提供数据。 ① P＜0.05。 Note: 1. NWNT: normal waist-normal triglycerides; NWET: normal waist-elevated triglycerides; EWNT: elevated waist-normal triglycerides; HTWP: hypertriglyceridemic-waist phenotype; SBP, systolic blood pressure; DBP: diastolic blood pressure; BMI: body mass index; FPG: fasting plasma glucose; TG: triglyceride; TC: total cholesterol; HDL-C: high density liptein cholesterol; LDL-C: low density lipoprotein cholesterol. 2. "―" indicates that the model did not provide data. ① P＜0.05.

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表 2 四组CRFs聚集的比较

Table 2. Comparison of clustering of CFRs among four groups

组别Group	CRFs聚集[人数(占比/%)] CRFs gathering [Number of people(proportion/%)]	模型1 Model 1		模型2 Model 2
组别Group		OR值(95% CI) OR value (95% CI)	P值 value	OR值(95% CI) OR value (95% CI)	P值 value
NWNT (n=1 115)	233(20.90)	1.00		1.00
NWET (n=462)	171(37.01)	2.22(1.75~2.82)	＜0.001	2.17(1.70~2.77)	＜0.001
EWNT (n=1 098)	632(57.56)	5.13(4.26~6.19)	＜0.001	6.43(5.26~7.86)	＜0.001
HTWP (n=1 377)	987(71.68)	9.58(7.95~11.54)	＜0.001	12.01(9.83~14.67)	＜0.001
注：1. HTWP：正常腰围-正常三酰甘油；NWET：单纯高三酰甘油；EWNT：单纯腹型肥胖；HTWP：高三酰甘油血症-腰围表型。 2. 模型1为单因素logistic回归分析模型；模型2为多因素logistic回归分析模型，校正了年龄、性别、居住地、教育程度、体力活动及饮酒。 Note: 1. NWNT: normal waist-normal triglycerides; NWET: normal waist-elevated triglycerides; EWNT: elevated waist-normal triglycerides; HTWP: hypertriglyceridemic-waist phenotype. 2. Model 1 was a single factor logistic regression analysis model; Model 2 was a multivariate logistic regression analysis model that adjusted for age, sex, place of residence, education, physical activity, and alcohol consumption.

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组别Group	NWNT(n=1 115)[人数(占比/%)] NWNT (n=1 115)[Number of people(proportion/%)]	NWET(n=462)[人数(占比/%)] NWET (n=462)[Number of people(proportion/%)]	EWNT(n=1 098)[人数(占比/%)] EWNT (n=1 098)[Number of people(proportion/%)]	HTWP(n=1 377)[人数(占比/%)] HTWP (n=1 377)[Number of people(proportion/%)]	H/χ²值value	P值value
年龄/岁, M(IQR) Age/years, M(IQR)	52(14.00)	50(12.00)	55(15.00) ^①	56(14.00) ^①	107.64	< 0.001
性别Sex					182.28	< 0.001
男Male	567(50.85)	265(57.36)	345(31.42) ^①	442(32.10) ^①	―
女Female	548(49.15)	197(42.64)	753(68.58) ^①	935(67.90) ^①	―
居住地Residence					29.53	< 0.001
城市Urban	576(51.66)	273(59.09) ^①	494(44.99) ^①	724(52.58)	―
农村Rural	539(48.34)	189(40.91) ^①	604(55.01) ^①	653(47.42)	―
受教育程度Education					31.94	< 0.001
高中及以下High school and below	825(73.99)	327(70.78)	886(80.69) ^①	1 104(80.17) ^①	―
高中以上Above high school	290(26.01)	135(29.22)	212(19.31) ^①	273(19.83) ^①	―
体力活动Physical activities	909(81.52)	344(74.46) ^①	875(79.69)	1 022(74.22) ^①	29.31	< 0.001
高血压Hypertension	428(38.39)	234(50.65) ^①	624(56.83) ^①	921(66.88) ^①	207.07	< 0.001
糖尿病Diabetes	31(2.78)	27(5.84) ^①	71(6.47) ^①	201(14.60) ^①	126.93	< 0.001
吸烟Smoking	308(27.62)	150(32.47)	415(37.80) ^①	500(36.31) ^①	31.04	< 0.001
饮酒Drinking	331(29.69	176(38.10) ^①	247(22.50) ^①	320(23.24) ^①	54.25	< 0.001
SBP/mmHg, M(IQR)	130.50(25.00)	134.00(26.60) ^①	138.75(28.10) ^①	145.00(28.50) ^①	274.35	< 0.001
DBP/mmHg, M(IQR)	84.00(14.00)	87.00(16.00) ^①	88.00(14.50) ^①	90.50(16.00) ^①	195.17	< 0.001
BMI/(kg·m^-2), M(IQR)	21.83(3.14)	22.89(3.43) ^①	25.20(3.91) ^①	26.23(3.90) ^①	1 446.68	< 0.001
WC/cm, M(IQR)	77(9.00)	79(10.00) ^①	90(10.00) ^①	90(10.00) ^①	2 008.39	< 0.001
FPG/(mmol·L^-1), M(IQR)	4.80(0.90)	4.90(1.00)	4.90(1.03) ^①	5.10(1.40) ^①	119.15	< 0.001
TG/(mmol·L^-1), M(IQR)	1.10(0.47)	2.32(1.18) ^①	1.25(0.48) ^①	2.56(1.45) ^①	2 965.31	< 0.001
TC/(mmol·L^-1), M(IQR)	4.99(1.29)	5.52(1.43) ^①	5.23(1.32) ^①	5.63(1.40) ^①	270.07	< 0.001
HDL-C/(mmol·L^-1), M(IQR)	1.27(0.26)	1.20(0.22) ^①	1.26(0.25)	1.20(0.24) ^①	190.30	< 0.001
LDL-C/(mmol·L^-1), M(IQR)	1.79(1.31)	1.87(1.14)	1.88(1.10)	1.96(1.07) ^①	22.01	< 0.001
注：1. HTWP：正常腰围-正常三酰甘油；NWET：单纯高三酰甘油；EWNT：单纯腹型肥胖；HTWP：高三酰甘油血症-腰围表型；SBP, 收缩压；DBP：舒张压；BMI：体质指数；FPG：空腹血糖；TG：三酰甘油；TC：总胆固醇；HDL-C：高密度脂蛋白胆固醇。LDL-C：低密度脂蛋白胆固醇； 2. “―”表示模型未提供数据。 ① P＜0.05。 Note: 1. NWNT: normal waist-normal triglycerides; NWET: normal waist-elevated triglycerides; EWNT: elevated waist-normal triglycerides; HTWP: hypertriglyceridemic-waist phenotype; SBP, systolic blood pressure; DBP: diastolic blood pressure; BMI: body mass index; FPG: fasting plasma glucose; TG: triglyceride; TC: total cholesterol; HDL-C: high density liptein cholesterol; LDL-C: low density lipoprotein cholesterol. 2. "―" indicates that the model did not provide data. ① P＜0.05.

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吉林省德惠市40岁及以上人群高TG血症-腰围表型与心血管危险因素聚集的关系

doi: 10.16462/j.cnki.zhjbkz.2023.08.016

通讯作者:
李凤娥，E-mail: 1059250609@qq.com

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Relationship between hypertriglyceridemic-waist phenotype and clustering of cardiovascular risk factors among residents aged 40 and above in Dehui City, Jilin Province

Corresponding author: LI Feng′e, E-mail: 1059250609@qq.com

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留言板

吉林省德惠市40岁及以上人群高TG血症-腰围表型与心血管危险因素聚集的关系

doi: 10.16462/j.cnki.zhjbkz.2023.08.016

通讯作者: 李凤娥，E-mail: 1059250609@qq.com

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出版历程

Relationship between hypertriglyceridemic-waist phenotype and clustering of cardiovascular risk factors among residents aged 40 and above in Dehui City, Jilin Province

Corresponding author: LI Feng′e, E-mail: 1059250609@qq.com

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出版历程

目录

通讯作者:
李凤娥，E-mail: 1059250609@qq.com