<i>rs12252</i> polymorphism of IFITM3 gene and influenza susceptibility in Chinese population: a study-based sequential Meta-analysis

ZHANG Tian-chen; LIU Xiao-qing; PAN Huan-hong; ZHAO Yu-qin

doi:10.16462/j.cnki.zhjbkz.2019.10.021

Volume 23 Issue 10

Oct. 2019

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2019 > 23(10): 1265-1272

ZHANG Tian-chen, LIU Xiao-qing, PAN Huan-hong, ZHAO Yu-qin. rs12252 polymorphism of IFITM3 gene and influenza susceptibility in Chinese population: a study-based sequential Meta-analysis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(10): 1265-1272. doi: 10.16462/j.cnki.zhjbkz.2019.10.021

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ZHANG Tian-chen, LIU Xiao-qing, PAN Huan-hong, ZHAO Yu-qin. rs12252 polymorphism of IFITM3 gene and influenza susceptibility in Chinese population: a study-based sequential Meta-analysis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(10): 1265-1272. doi: 10.16462/j.cnki.zhjbkz.2019.10.021

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rs12252 polymorphism of IFITM3 gene and influenza susceptibility in Chinese population: a study-based sequential Meta-analysis

doi: 10.16462/j.cnki.zhjbkz.2019.10.021

1.
Emergency Office and Acute Infectious Disease Prevention Institute, JiangXi Province Center for Disease Control and Prevention, Nanchang 330029, China
2.
Department of Infectious Diseases Prevention and Control, Chinese Center for Disease Control and Prevention, Beijing 102206, China

Funds:

Science and Technology Plan of jiangxi Provincial Health and Family Planning Commission 20156031

Received Date: 2019-04-09
Rev Recd Date: 2019-06-10
Publish Date: 2019-10-10

Abstract

Abstract

Objective To systematically and quantitatively evaluate the relationship of rs12252 polymorphism in IFITM3 gene and susceptibility to influenza in Chinese population. Methods The databases of Medline, PubMed, Embase, Web of Science, China National knowledge infrastructure (CNKI), Wanfang and VIP were searched to retrieve the articles which focused on the topic of relationship between the rs12252 polymorphism and susceptibility to influenza in Chinese population. Meta-analysis method was used to comprehensively and quantitatively analyze the enrolled articles. Results Seven papers with a total of 919 influenza cases were involved in this article. Influenza virus involved influenza A (H7N9, H1N1 pmd09, H3N2) and influenza B. Study-based sequential meta-analysis of the study showed that the total sample size of this study have achieved the required sample size to obtain stable positive results. The results of this meta-analysis showed that the rs12252 polymorphism was associated with susceptibility to influenza in Chinese population and that the rs12252C polymorphism in IFITM3 gene was more susceptible to have influenza in Chinese people (C vs T: OR=1.67, 95% CI: 1.45-1.92; CC vs TT: OR=2.61, 95% CI: 1.97-3.46; TC vs TT: OR=1.55, 95% CI: 1.20-2.00; CC vs TC+TT: OR=2.01, 95% CI: 1.49-2.72; CC+TC vs TT: OR=8.90, 95% CI: 4.94-16.06). Conclusion the rs12252 polymorphism of IFITM3 gene was a risk factor for influenza in Chinese population.
- IFITM3,
- rs12252,
- Polymorphism,
- Influenza,
- Meta-analysis

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References(38)

References

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