Correlation between metabolic syndrome component aggregation and nonalcoholic fatty liver disease in a certain district of Urumqi's check-up population

GULISIYA Hailili; YAO Hua; WANG Shu-xia; WANG Yu-shan; LIU Tao; CHEN Zhen; LUO Tao; DAI Jiang-hong

doi:10.16462/j.cnki.zhjbkz.2019.11.012

Volume 23 Issue 11

Nov. 2019

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GULISIYA Hailili, YAO Hua, WANG Shu-xia, WANG Yu-shan, LIU Tao, CHEN Zhen, LUO Tao, DAI Jiang-hong. Correlation between metabolic syndrome component aggregation and nonalcoholic fatty liver disease in a certain district of Urumqi's check-up population[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(11): 1358-1363. doi: 10.16462/j.cnki.zhjbkz.2019.11.012

Citation:

GULISIYA Hailili, YAO Hua, WANG Shu-xia, WANG Yu-shan, LIU Tao, CHEN Zhen, LUO Tao, DAI Jiang-hong. Correlation between metabolic syndrome component aggregation and nonalcoholic fatty liver disease in a certain district of Urumqi's check-up population[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(11): 1358-1363. doi: 10.16462/j.cnki.zhjbkz.2019.11.012

Citation:

GULISIYA Hailili, YAO Hua, WANG Shu-xia, WANG Yu-shan, LIU Tao, CHEN Zhen, LUO Tao, DAI Jiang-hong. Correlation between metabolic syndrome component aggregation and nonalcoholic fatty liver disease in a certain district of Urumqi's check-up population[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(11): 1358-1363. doi: 10.16462/j.cnki.zhjbkz.2019.11.012

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Correlation between metabolic syndrome component aggregation and nonalcoholic fatty liver disease in a certain district of Urumqi's check-up population

doi: 10.16462/j.cnki.zhjbkz.2019.11.012

1.
School of Public Health, Xinjiang Medical University, 830011, Urumqi, China
2.
Health Management Center, the First Affiliated Hospital of Xinjiang Medical University, 830000, Urumqi, China

Funds:

National key research and development plan project: Xinjiang multi-ethnic cohort study 2017YFC0907203

Xinjiang Uygur autonomous region natural science foundation project 2017D01C425

More Information

Corresponding author: DAI Jiang-hong, E-mail: epi102@sina.com
Received Date: 2019-07-07
Rev Recd Date: 2019-10-05
Publish Date: 2019-11-10

Abstract

Abstract

Objective The relationship between metabolic syndrome(MetS), metabolic syndrome score (MSS) and non-alcoholic fatty liver disease(NAFLD) in Urumqi was investigated by the MSS, reflecting the aggregation of MetS components. Methods The subjects were divided into non-NAFLD and NAFLD group by abdominal B ultrasound. The results of physical examination and blood biochemical examination were analyzed. The MSS was calculated and the relationship between the different aggregation of MSS and NAFLD was analyzed by Log-binomial regression. Results A total of 20 569 subjects were included in the study. The detection rate of MetS was 16.7%, the detection rate of NAFLD was 32.4%. Compared with non-NAFLD group, the systolic blood pressure, diastolic blood pressure, body mass index (BMI), waist circumference, fasting plasma glucose, triglyceride, total cholesterol, and low-density lipoprotein cholesterol were all increased in the NAFLD group, and the difference was statistically significant (P < 0.05). After adjusting for gender, age, ethnicity and education level, Log-binomial regression analysis showed high BMI, hypertension and hyperglycemia. High triglycerides and low-density lipoproteins are the main risk factors for NAFLD (PR values were 3.194, 1.331, 1.623, 1.981, 1.254, respectively); the risk of NAFLD increased corresondingly when MSS, MSS0, MSS1, MSS2, MSS3, and MSS4 increased. The PR were 3.127, 4.983, 6.437, and 7.331, respectively. Conclusions The formation of NAFLD is not a single accumulation of liver fat, combined with abnormalities such as blood lipids, blood pressure, and blood sugar. The detection rate of male MetS and NAFLD was higher than that of female, but women with two abnormal metabolic indicators were more likely to develop into NAFLD. BMI as the obesity index has the strongest relationship with NAFLD, and NAFLD prevention should focus on obese people.
- Metabolic syndrome,
- Metabolic syndrome score,
- Nonalcoholic fatty liver disease

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志谢: 感谢新疆医科大学健康管理院、新疆维吾尔自治区卫生健康委员会提供数据支持

References(12)

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