Analysis on clinical laboratory indicators of different prognostic patients with severe fever with thrombocytopenia syndrome

ZHANG Hong-yan; CHEN Gui-liu; LI Wen-ting; LENG Rui-xue; QIN Wei-zi

doi:10.16462/j.cnki.zhjbkz.2020.03.022

Volume 24 Issue 3

Jun. 2020

Turn off MathJax

Article Contents

Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2020 > 24(3): 365-368

ZHANG Hong-yan, CHEN Gui-liu, LI Wen-ting, LENG Rui-xue, QIN Wei-zi. Analysis on clinical laboratory indicators of different prognostic patients with severe fever with thrombocytopenia syndrome[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(3): 365-368. doi: 10.16462/j.cnki.zhjbkz.2020.03.022

Citation:

ZHANG Hong-yan, CHEN Gui-liu, LI Wen-ting, LENG Rui-xue, QIN Wei-zi. Analysis on clinical laboratory indicators of different prognostic patients with severe fever with thrombocytopenia syndrome[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(3): 365-368. doi: 10.16462/j.cnki.zhjbkz.2020.03.022

Citation:

ZHANG Hong-yan, CHEN Gui-liu, LI Wen-ting, LENG Rui-xue, QIN Wei-zi. Analysis on clinical laboratory indicators of different prognostic patients with severe fever with thrombocytopenia syndrome[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(3): 365-368. doi: 10.16462/j.cnki.zhjbkz.2020.03.022

PDF( 850 KB)

Analysis on clinical laboratory indicators of different prognostic patients with severe fever with thrombocytopenia syndrome

doi: 10.16462/j.cnki.zhjbkz.2020.03.022

ZHANG Hong-yan^{1, 2},
CHEN Gui-liu³,
LI Wen-ting⁴,
LENG Rui-xue^{1
,
,},
QIN Wei-zi^{3
,
,}

1.
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei 230032, China
2.
Propaganda Department of Party Committee, Chaohu Hospital of Anhui Medical University, Hefei 238000, China
3.
Department of Prevention and Health Protection, The First Affiliated Hospital of USTC, Hefei 230001, China
4.
Department of Infectious Diseases, The First Affiliated Hospital of USTC, Hefei 230001, China

Funds: Key Research and Development Plan of Anhui Province(1704e1002231)

More Information

Corresponding author: LENG Rui-xue, E-mail:lengruixue@ahmu.edu.cn; QIN Wei-zi, E-mail:463946031@qq.com
Received Date: 2019-09-20
Rev Recd Date: 2020-01-02
Publish Date: 2020-03-10

Abstract

Abstract

Objective To analyze the clinical laboratory indicators of severe fever with thrombocytopenia syndrome(SFTS) patients caused by novel Bunyavirus infection, and focus on comparing the indicators of severe patients with different prognosis. The findings may help to predict poor prognosis for severe patients in the early stage. Methods The clinical laboratory indicators of all diagnosed confirmedly patients in two Hospitals, from January 2011 to December 2018, and the differences between groups were analyzed. Results A total of 168 clinically diagnosed SFTS cases(117 cases of non-severe cases and 51 cases of severe cases) were included in this study. In the severe cases, the prognosis was improved in 30 cases and the prognosis was poor in 21 cases. The laboratory indicators of severe patients with different prognosis were compared. The data showed that the levels of several indicators in patients with poor prognosis were statistically different with these in patients with better prognosis. In addition, the proportion of coma, diffuse intravascular coagulation and heart failure in patients with poor prognosis was significantly higher than that in patients with improved prognosis(all P < 0.05). Conclusion Differentiated prevention and treatment strategies should be developed for severe patients with possible poor prognosis.
- Severe fever with thrombocytopenia syndrome,
- Novel Bunyavirus infections,
- Clinical laboratory features,
- Severe disease,
- Prognosis

FullText(HTML)

References(9)

References

[1]	Yu XJ, Liang MF, Zhang SY, et al. Fever with thrombocytopenia associated with a novel bunvavirus in China[J]. N Engl J Med, 2011, 364(16): 1523-1532. DOI: 10.1056/NEJMoa1010095.
[2]	Sun Y, Liang M, Qu J, et al. Early diagnosis of novel SFTS bunyavirus infection by quantitative real-time RT-PCR assay[J]. J Clin Virol, 2012, 53(1): 48-53. DOI: 10.1016/j.jcv.2011.09.031.
[3]	Cui F, Cao HX, Wang L, et al. Clinical and epidemiological study on severe fever with thrombocytopenia syndrome in Yiyuan County, Shandong Province, China[J]. Am J Trop Med Hyg, 2013, 88(3): 510-512. DOI: 10.4269/ajtmh.11-0760.11.
[4]	Cui N, Bao XL, Yang ZD, et al. Clinical progression and predictors of death in patients with severe fever with thrombocytopenia syndrome in China[J]. J Clin Virol, 2014, 59(1): 12-17. DOI: 10.1016/j.jcv.2013.10.024.
[5]	Deng B, Zhou B, Zhang S, et al. Clinical features and factors associated with severity and fatality among patients with severe fever with thrombocytopenia syndrome Bunyavirus infection in Northeast China[J]. PLoS One, 2013, 8(11): e80802. DOI: 10.1371/journal.pone.0080802.
[6]	Jia B, Yan X, Chen Y, et al. A scoring model for predicting prognosis of patients with severe fever with thrombocytopenia syndrome[J]. PLoS Negl Trop Dis, 2017, 11(9): e0005909. DOI: 10.1371/journal.pntd.0005909.
[7]	伍婷, 柳燕, 李鸿儒, 等.巢湖地区新布尼亚病毒感染患者的临床特点和病重相关危险因素分析[J].中华疾病控制杂志, 2017, 21(1): 56-60. DOI: 10.16462/j.cnki.zhjbkz.2017.01.013. Wu T, Liu Y, Li HR, et al. Clinical features and prognostic risk factors of novel Bunyavirus infection in Chaohu area[J]. Chin J Dis Control Prev, 2017, 21(1): 56-60. DOI: 10.16462/j.cnki.zhjbkz.2017.01.013.
[8]	曹琛, 吴家兵, 曹明华, 等.安徽省2011-2015年发热伴血小板减少综合征流行特征分析[J].中华疾病控制杂志, 2016, 20(8): 792-795. DOI: 10.16462/j.cnki.zhjbkz.2016.08.010. Cao C, Wu JB, Cao MH, et al. Epidemiological analysis on severe fever with thrombocytopenia syndrome in Anhui Province, 2011-2015[J]. Chin J Dis Control Prev, 2016, 20(8): 792-795. DOI: 10.16462/j.cnki.zhjbkz.2016.08.010.
[9]	毛雪兰, 邓宝成.重症发热伴血小板减少综合征临床特征分析[J].中国全科医学, 2019, 22(24): 2979-2984. DOI: 10.12114/j.issn.1007-9572.2018.00.432. Mao XL, Deng BC. Clinical features of critically ill patients with severe fever with thrombocytopenia syndrome[J]. Chin Gen Prac, 2019, 22(24): 2979-2984. DOI: 10.12114/j.issn.1007-9572.2018.00.432.