Association and interaction effect between lifestyle index and gene polymorphisms on hyperuricemia in Liangshan residents

LI Ting-ting; LI Shuang-jing; TIAN Tian; NIE Zhi-chao; XU Wang-dong; LIU Long-jian; JIA Hong

doi:10.16462/j.cnki.zhjbkz.2021.01.008

Volume 25 Issue 1

Jan. 2021

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LI Ting-ting, LI Shuang-jing, TIAN Tian, NIE Zhi-chao, XU Wang-dong, LIU Long-jian, JIA Hong. Association and interaction effect between lifestyle index and gene polymorphisms on hyperuricemia in Liangshan residents[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(1): 37-42. doi: 10.16462/j.cnki.zhjbkz.2021.01.008

Citation:

LI Ting-ting, LI Shuang-jing, TIAN Tian, NIE Zhi-chao, XU Wang-dong, LIU Long-jian, JIA Hong. Association and interaction effect between lifestyle index and gene polymorphisms on hyperuricemia in Liangshan residents[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(1): 37-42. doi: 10.16462/j.cnki.zhjbkz.2021.01.008

Citation:

LI Ting-ting, LI Shuang-jing, TIAN Tian, NIE Zhi-chao, XU Wang-dong, LIU Long-jian, JIA Hong. Association and interaction effect between lifestyle index and gene polymorphisms on hyperuricemia in Liangshan residents[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(1): 37-42. doi: 10.16462/j.cnki.zhjbkz.2021.01.008

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Association and interaction effect between lifestyle index and gene polymorphisms on hyperuricemia in Liangshan residents

doi: 10.16462/j.cnki.zhjbkz.2021.01.008

1.
School of Public Health, Southwest Medical University, Luzhou 646000, China
2.
Department of Epidemiology and Biostatistics, School of Public Health, Drexel University, Philadelphia, PA 19012, the United States

Funds:

Danone Nutrition Center Dietary Nutrition Research and Education Fund DIC2013-03

More Information

Corresponding author: JIA Hong, E-mail: jhong_lz@163.com
Received Date: 2020-07-23
Rev Recd Date: 2020-10-24
Publish Date: 2021-01-10

Abstract

Abstract

Objective To explore the impact of lifestyle index and gene interaction on hyperuricemia of residents in Liangshan area. Methods Questionnaire survey, physical measurement and blood sample were conducted from 2 646 residents in Liangshan area. Lifestyle index was constructed by using smoking, drinking, physical activity and body mass index (BMI). Logistic regression model was used to explore the relationship among lifestyle index, SNP locus and HUA. The additive and multiplication model were used to analyze the impact of lifestyle index-gene interaction on HUA. Results Logistic regression analysis showed that after adjusting for age, gender and ethnicity, a lifestyle index score of 3 reduces the risk of HUA by 63.7% compared with score of 0 (OR=0.363, 95% CI: 0.232-0.566, P < 0.001); The TT mutation genotype at rs2231142 had HUA 2.993 times than that of GG wild type (OR=2.993, 95% CI: 2.015-4.445, P < 0.001), the TT mutation genotype at rs11722228 increased the risk of HUA by 39.2% (OR=1.392, 95% CI: 1.029-1.884, P=0.032). The interaction analysis showed that there was a synergistic additive interaction between the lifestyle index and the ABCG2 gene rs2231142 locus on HUA (RERI=1.136, 95% CI:0.036-2.236; AP=0.311, 95% CI: 0.115-0.507; S=1.749, 95% CI: 1.168-2.620), but there was no multiplicative interaction between lifestyle index and rs2231142 and rs11722228. Conclusions There is a synergistic additive interaction between the lifestyle index and the ABCG2 gene rs2231142 locus on HUA. When an individual carries the T mutation genotype, adopting an unhealthy lifestyle will increase the risk of HUA.
- Hyperuricemia,
- Lifestyle index,
- Gene,
- Interaction

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References(27)

References

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