Correlation analysis on trimethylamine N-oxide and its metabolites in early pregnancy with overweight

CAO Shu; LENG Jun-hong; LI Wei-qin; FANG Zhong-ze; YANG Xi-lin; HUO Xiao-xu

doi:10.16462/j.cnki.zhjbkz.2021.02.010

Volume 25 Issue 2

Feb. 2021

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CAO Shu, LENG Jun-hong, LI Wei-qin, FANG Zhong-ze, YANG Xi-lin, HUO Xiao-xu. Correlation analysis on trimethylamine N-oxide and its metabolites in early pregnancy with overweight[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(2): 171-175. doi: 10.16462/j.cnki.zhjbkz.2021.02.010

Citation:

CAO Shu, LENG Jun-hong, LI Wei-qin, FANG Zhong-ze, YANG Xi-lin, HUO Xiao-xu. Correlation analysis on trimethylamine N-oxide and its metabolites in early pregnancy with overweight[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(2): 171-175. doi: 10.16462/j.cnki.zhjbkz.2021.02.010

Citation:

CAO Shu, LENG Jun-hong, LI Wei-qin, FANG Zhong-ze, YANG Xi-lin, HUO Xiao-xu. Correlation analysis on trimethylamine N-oxide and its metabolites in early pregnancy with overweight[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(2): 171-175. doi: 10.16462/j.cnki.zhjbkz.2021.02.010

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Correlation analysis on trimethylamine N-oxide and its metabolites in early pregnancy with overweight

doi: 10.16462/j.cnki.zhjbkz.2021.02.010

1.
School of Public Health, Tianjin Medical University, Tianjin 300070, China
2.
Tianjin Women and Children Health Center, Tianjin 300070, China

Funds:

Project of Youth Science Foundation of National Natural Science Foundation of China 81900724

National Natural Science Foundation of China 81870549

More Information

Corresponding author: HUO Xiao-xu, E-mail: huoxiaoxu@tmu.edu.cn
Received Date: 2020-07-15
Rev Recd Date: 2020-11-08
Publish Date: 2021-02-10

Abstract

Abstract

Objective To explore the differences in the distribution of trimethylamine N-oxide (TMAO) and its metabolites in pregnant women under different weight status in early pregnancy, and analyze the relationship between TMAO and its metabolites and overweight. Methods A pregnancy cohort of 22 302 pregnant women was established in Tianjin from October 1 2010 to August 31 2012, and then gestational diabetes mellitus (GDM) was selected as the target disease. The nested case-control study included 243 pregnant women who developed GDM between 24 and 28 weeks of pregnancy. At the same time, a 1:1 match was made according to (age ±1) year. The final analysis included 486 subjects. The serum TMAO and its metabolites were determined by liquid chromatography-tandem mass spectrometry. Subjects were divided into overweight group and non-overweight group according to BMI≥24.0 kg/m² and BMI < 24.0 kg/m², TMAO and its metabolites were divided into high and low levels by percentile method, and binary logistic regression analysis was performed. Results The level of overweight group trimethylamine (TMA) was significantly higher than that of non-overweight group, the difference was statistically significant (Z=-2.747, P=0.006). Logistic regression analysis showed that when the confounding factors were not adjusted, compared with pregnant women with low TMA, the OR value of overweight at TMA≥264.5 nmol/mL was 1.771 (95% CI: 1.193-2.629, P=0.005); After adjusting for confounding factors, the OR value of overweight at TMA≥264.5 nmol/mL was 1.734 (95% CI: 1.063-2.827, P=0.027). Conclusions The level of TMA in early pregnancy is significantly related to the overweight of pregnant women. By adjusting the level of TMAO and its metabolites, it may provide new ideas for the control and treatment of metabolic syndromes such as obesity and diabetes.
- Early pregnancy,
- Trimethylamine oxide,
- Overweight

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References(19)

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