Interaction between family history of diabetes and dyslipidemia on risk of diabetes

LI Min; QI Zhi-gang; GU Yun-juan; ZHENG Hui-yan; GE Qi-wei; QIN Gang; WANG Yin-chu; WANG Yu-qi; CHU Min-jie; ZHUANG Xun

doi:10.16462/j.cnki.zhjbkz.2021.03.010

Volume 25 Issue 3

Mar. 2021

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2021 > 25(3): 300-305

LI Min, QI Zhi-gang, GU Yun-juan, ZHENG Hui-yan, GE Qi-wei, QIN Gang, WANG Yin-chu, WANG Yu-qi, CHU Min-jie, ZHUANG Xun. Interaction between family history of diabetes and dyslipidemia on risk of diabetes[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(3): 300-305. doi: 10.16462/j.cnki.zhjbkz.2021.03.010

Citation:

LI Min, QI Zhi-gang, GU Yun-juan, ZHENG Hui-yan, GE Qi-wei, QIN Gang, WANG Yin-chu, WANG Yu-qi, CHU Min-jie, ZHUANG Xun. Interaction between family history of diabetes and dyslipidemia on risk of diabetes[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(3): 300-305. doi: 10.16462/j.cnki.zhjbkz.2021.03.010

Citation:

LI Min, QI Zhi-gang, GU Yun-juan, ZHENG Hui-yan, GE Qi-wei, QIN Gang, WANG Yin-chu, WANG Yu-qi, CHU Min-jie, ZHUANG Xun. Interaction between family history of diabetes and dyslipidemia on risk of diabetes[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(3): 300-305. doi: 10.16462/j.cnki.zhjbkz.2021.03.010

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Interaction between family history of diabetes and dyslipidemia on risk of diabetes

doi: 10.16462/j.cnki.zhjbkz.2021.03.010

1.
School of Public Health, Nantong University, Nantong 226019, China
2.
Center for Disease Control and Prevention, Chongchuan District, Nantong 226000, China
3.
Affiliated Hospital of Nantong University, Nantong 226001, China
4.
The Third Hospital affiliated to Nantong University, Nantong 226000, China

Funds:

Key Project of People's Livelihood Science and Technology of Nantong Municipal Science and Technology Bureau MS22019005

More Information

Corresponding author: ZHUANG Xun, E-mail: xzhuang@ntu.edu.cn
Received Date: 2020-09-24
Rev Recd Date: 2020-12-17
Publish Date: 2021-03-10

Abstract

Abstract

Objective To explore the interaction between family history of diabetes and dyslipidemia on the risk of diabetes. Methods Based on the data of 13 382 residents surveyed by the project "National Demonstration Zone for Comprehensive Prevention and Control of Chronic Diseases" in Chongchuan District, Nantong City, Jiangsu Province in 2018, 3 209 blood glucose information were obtained. Logistic regression analysis was utilized to analyze the correlation of family history and dyslipidemia on the risk of diabetes, and an additive model was conducted to evaluate the impact of their interaction effect on diabetes. The gender difference of their interaction was also explored. Results The prevalence of diabetes was 17.3%, the standardized prevalence was 12.9%. The proportion of individuals who had family history and dyslipidemia was 8.8% and 7.6% respectively. After adjusting confounding factors such as age, smoking, alcohol consumption and high fat diet, it showed that family history and dyslipidemia had synergistic effects on the risk of diabetes. When family history and dyslipidemia existed concurrently, the risk of diabetes for males and females was 15.24 times (95% CI: 4.57-50.82) and 9.84 times (95% CI: 4.58-21.12) higher than normal. In male, the RERI, AP%, S, AP×(AB)% was 6.59, 43.2%, 1.86 and 46.3% respectively; In female, the RERI, AP%, S, AP×(AB)% was 4.22, 42.9%, 1.91, and 47.7% respectively. Conclusions Family history of diabetes and dyslipidemia has synergistic impact on risk of diabetes, and the interaction effect among males may be stronger than females.
- Diabetes mellitus,
- Family history,
- Dyslipidemia,
- Interaction

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References(21)

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