A systematic review and Meta-analysis on the carcinogenic risk difference of HBV subtypes

WU Ming-shan; LIU Zhen-qiu; WU Xue-fu; SHI Ting-ting; ZHANG Xin; ZHANG Tie-jun

doi:10.16462/j.cnki.zhjbkz.2021.03.014

Volume 25 Issue 3

Mar. 2021

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2021 > 25(3): 323-328

WU Ming-shan, LIU Zhen-qiu, WU Xue-fu, SHI Ting-ting, ZHANG Xin, ZHANG Tie-jun. A systematic review and Meta-analysis on the carcinogenic risk difference of HBV subtypes[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(3): 323-328. doi: 10.16462/j.cnki.zhjbkz.2021.03.014

Citation:

WU Ming-shan, LIU Zhen-qiu, WU Xue-fu, SHI Ting-ting, ZHANG Xin, ZHANG Tie-jun. A systematic review and Meta-analysis on the carcinogenic risk difference of HBV subtypes[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(3): 323-328. doi: 10.16462/j.cnki.zhjbkz.2021.03.014

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A systematic review and Meta-analysis on the carcinogenic risk difference of HBV subtypes

doi: 10.16462/j.cnki.zhjbkz.2021.03.014

Department of Epidemiology, School of Public Health, Fudan University, China and Key Laboratory of Public Health Safety (Fudan University), Ministry of Education, Shanghai 200032, China

Funds:

National Natural Science Foundation of China 81772170

More Information

Corresponding author: ZHANG Tie-jun, E-mail: tjzhang@shmu.edu.cn
Received Date: 2020-09-14
Rev Recd Date: 2021-01-04
Publish Date: 2021-03-10

Abstract

Abstract

Objective To explore the risk difference and potential mechanisms on the hepatocellular carcinogenesis of different HBV genotypes. Methods Literatures were retrieved from PubMed, Web of Science, Embase databases Wanfang data and CNKI. Data were synthesized by meta-analysis methods. HBV sequences were obtained from NCBI-GenBank and the mutation frequency of different HBV genotypes were calculated. Results A total of 1 066 studies were retrieved via literature search. Finally, 17 studies were included in the Meta-analysis after eligibility screening. The total number of study subjects was 16 288, including 3 613 liver cancer patients. Patients with HBV C genotype had a higher risk of liver cancer than genotypes A, B, and D. While no significant difference in the risk of liver cancer across genotypes A, B and D was observed. The frequency of mutations indicated that most mutations were more frequently occurred in genotype C compared with other genotypes. Conclusions HBV genotype C is associated with a higher risk of hepatocellular carcinoma than other genotypes, which might due to more risk mutations genotype C HBV possessed.
- HBV,
- Genotype,
- Liver cancer,
- Meta-analysis

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References(29)

References

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