Continuous monitoring of evolution and variation of influenza A (H1N1) viruses in Guangzhou, 2017-2019

CAO Lan; LI Kui-biao; CHEN Yi-yun; WU Di; ZENG Qing; XIA Dan; LIU Yan-hui; DI Biao; ZHANG Zhou-bin

doi:10.16462/j.cnki.zhjbkz.2021.03.020

Volume 25 Issue 3

Mar. 2021

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2021 > 25(3): 359-362

CAO Lan, LI Kui-biao, CHEN Yi-yun, WU Di, ZENG Qing, XIA Dan, LIU Yan-hui, DI Biao, ZHANG Zhou-bin. Continuous monitoring of evolution and variation of influenza A (H1N1) viruses in Guangzhou, 2017-2019[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(3): 359-362. doi: 10.16462/j.cnki.zhjbkz.2021.03.020

Citation:

CAO Lan, LI Kui-biao, CHEN Yi-yun, WU Di, ZENG Qing, XIA Dan, LIU Yan-hui, DI Biao, ZHANG Zhou-bin. Continuous monitoring of evolution and variation of influenza A (H1N1) viruses in Guangzhou, 2017-2019[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(3): 359-362. doi: 10.16462/j.cnki.zhjbkz.2021.03.020

Citation:

CAO Lan, LI Kui-biao, CHEN Yi-yun, WU Di, ZENG Qing, XIA Dan, LIU Yan-hui, DI Biao, ZHANG Zhou-bin. Continuous monitoring of evolution and variation of influenza A (H1N1) viruses in Guangzhou, 2017-2019[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(3): 359-362. doi: 10.16462/j.cnki.zhjbkz.2021.03.020

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Continuous monitoring of evolution and variation of influenza A (H1N1) viruses in Guangzhou, 2017-2019

doi: 10.16462/j.cnki.zhjbkz.2021.03.020

1.
Department of Virology and Immunology, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
2.
Department of Infectious Disease Prevention and Control, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
3.
Office of the Director, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China

Funds:

Natural Science Foundation of Guangdong Province 2019A1515011510

Natural Science Foundation of Guangdong Province 2019A1515011407

Guangzhou Health and Family Planning Science and Technology Project 20201A011052

Project for Key Medicine Discipline Construction of Guangzhou Municipality 2021-2023-11

National Science and Technology Project 2017ZX10103011-005

More Information

Corresponding author: ZHANG Zhou-bin, E-mail: gzcdczzb@qq.com
Received Date: 2020-06-11
Rev Recd Date: 2020-08-12
Publish Date: 2021-03-10

Abstract

Abstract

Objective The characteristics of the evolution and variation of influenza A (H1N1) viruses in Guangzhou were monitored, which could provide research data for the scientific prevention and control of influenza A (H1N1). Methods The Hemagglutinin (HA) and Neuraminidase (NA) genes of 132 isolates of influenza A (H1N1) virus were sequenced isolated in Guangzhou from 2017 to 2019. The molecular characteristics of viruses in different epidemic years were analyzed. Results The HA and NA genes of H1N1 epidemic strains were clustered together, suggesting that they had the same evolutionary origin. The isolates in 2019 evolved from the isolates from 2017 to 2018 successively, which showed an obvious trend of evolution. The mutated antigenic sites of HA protein were at 91, 181 and 202 sites. Especially, the antigenic variations of HA protein of H1N1 epidemic strain in 2018 had diversities. In 2017 and 2019, three isolates were detected, which had H274Y resistance mutation of neuraminidase inhibitor. Conclusions The match between H1N1 epidemic strains from 2017 to 2019 and vaccine strains in the same year in Guangzhou was good. But, the HA and NA genes were evolving and mutating continuously. Gene polymorphisms were found at antigen sites and drug resistance sites.
- Influenza A (H1N1) virus,
- Gene evolution,
- Variation

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References(13)

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