Analysis of etiological characteristics of hand-foot-mouth disease (HFMD) in Lu'an City from 2010 to 2018

YANG Wei; LI Xiu-de; CHANG Hong-wei

doi:10.16462/j.cnki.zhjbkz.2021.03.022

Volume 25 Issue 3

Mar. 2021

Turn off MathJax

Article Contents

Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2021 > 25(3): 368-372

YANG Wei, LI Xiu-de, CHANG Hong-wei. Analysis of etiological characteristics of hand-foot-mouth disease (HFMD) in Lu'an City from 2010 to 2018[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(3): 368-372. doi: 10.16462/j.cnki.zhjbkz.2021.03.022

Citation:

YANG Wei, LI Xiu-de, CHANG Hong-wei. Analysis of etiological characteristics of hand-foot-mouth disease (HFMD) in Lu'an City from 2010 to 2018[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(3): 368-372. doi: 10.16462/j.cnki.zhjbkz.2021.03.022

Citation:

PDF( 797 KB)

Analysis of etiological characteristics of hand-foot-mouth disease (HFMD) in Lu'an City from 2010 to 2018

doi: 10.16462/j.cnki.zhjbkz.2021.03.022

Microbiological Laboratory, Lu'an Municipal Center for Disease Control and Prevention, Lu'an 237000, China

Funds:

Research Project of Preventive Medicine and Public Health in Anhui Province 2011Y0111

More Information

Corresponding author: CHANG Hong-wei, E-mail: 984368706@qq.com
Received Date: 2020-05-25
Rev Recd Date: 2020-07-01
Publish Date: 2021-03-10

Abstract

Abstract

Objective The etiogical characteristics of hand-foot-mouth disease (HFMD) in Lu'an City from 2010 to 2018 were analyzed to provide basis for the prevention and control of HFMD. Methods Pharyngeal swabs were collected from clinical-diagnosis-case of HFMD in all counties and districts of Lu'an City from 2010 to 2018. Quantitative real-time PCR was used to detect Enterovirus nucleic acid, and the detection results were analyzed. Results Among the 2 360 pharyngeal swabs collected from clinical-diagnosis-case of HFMD, 1 085 (45.97%) were positive from Enterovirus. There were 382 (35.21%) of Enterovirus 71 (EV71), 334 (30.78%) of Coxsackievirus A16 (COXA16), 169 (15.58%) of Coxsackievirus A6 (COXA6), 15 (1.38%) of Coxsackievirus A10 (COXA10), and 185 (17.05%) of other Enteroviruses. EV71 was the dominant strain from 2010 to 2014 and 2016 (χ²=188.555, P < 0.001), and COXA6 was the dominant strain in 2015 and 2017 (χ²=258.732, P < 0.001). The positive rate was significantly different in different counties (χ²=68.879, P < 0.001), with the highest rate in Yeji District (81.25%, 52/64), and the lowest rate in Huoqiu County (30.41%, 52/171). The number of patients in 1-3-year-old group was the highest, accounting for 68.11% (739/1 085) of the total positive cases in each age group. Among the 1 085 positive cases, 705 were male and 380 were female, but there was no statistical difference in the positive detection rate (χ²=1.354, P=0.245). Conclusions There are various types of HFMD pathogens in Lu'an City, and the dominant strains change every year. Factors such as season, age, region and gender can affect the prevalence of HFMD. Strengthening the monitoring of HFMD pathogen is helpful to prevent and control HFMD.
- Hand-foot-mouth disease (HFMD),
- Enterovirus,
- Etiology

FullText(HTML)

References(13)

References

[1]	Zhuang ZC, Kou ZQ, Bai YJ, et al. Epidemiological research on hand, foot, and mouth disease in mainland China[J]. Viruses, 2015, 7(12): 6400-6411. DOI: 10.3390/v7122947.
[2]	Kim BI, Ki H, Park S, et al. Effect of climatic factors on hand, foot, and mouth disease in South Korea, 2010-2013[J]. PLoS One, 2016, 11(6): e0157500. DOI: 10.1371/journal.pone.0157500.
[3]	中国疾病预防控制中心. 手足口病实验室手册(第4版)[EB/OL]. (2010-06-12)[2019-11-15]. http://cdcp.gd.gov.cn/func/content/post_1105740.html Chinese Center for Disease Control and Prevention. Laboratory manual for hand, foot and mouth disease (4th Edition)[EB/OL]. (2010-06-12)[2019-11-15]. http://cdcp.gd.gov.cn/func/content/post_1105740.html
[4]	王惠峰, 陶立新. 2009年－2015年上海市奉贤区手足口病病原检测结果分析[J]. 中国卫生检验杂志, 2017, 25(13): 2189-2191. Wang HF, Tao LX. Analysis of etiological detection results of hand-foot-mouth disease in Fengxian District of Shanghai from 2014 to 2015[J]. Chin J Health Lab Tec, 2017, 25(13): 2189-2191.
[5]	蒋露芳, 居丽雯, 杨吉星, 等. 2008年上海及周边地区婴幼儿手足口病病原学研究[J]. 中华传染病杂志, 2009, 27(7): 408-412. DOI: 10.3760/cma.j.issn.1000-6680.2009.07.006. Jiang LF, Ju LW, Yang JX, et al. Etiology of HFMD in Shanghai and its surrounding areas in 2008[J]. Chin J Infec Dis, 2009, 27(7): 408-412. DOI: 10.3760/cma.j.issn.1000-6680.2009.07.006.
[6]	叶建武, 李羽敏, 叶碧峰, 等. 莲都区2011年-2013年手足口病病原学特征分析[J]. 中国卫生检验杂志, 2015, 25(8): 1239-1241. Ye JW, Li YM, Ye BF, et al. Etiological analysis of HFMD features in Liandu district from 2011 to 2013[J]. Chin J Health Lab Tec, 2015, 25(8): 1239-1241.
[7]	曾汉日, 陆靖, 李晖, 等. 广东省2008－2013年柯萨奇A6型肠道病毒的流行及其基因特征分析[J]. 中华微生物和免疫学杂志, 2014, 34(10): 742-746. DOI: 10.3760/cma.j.issn.0254-5101.2014.10.003. Zeng HR, Lu J, Li H, et al. Epidemic and genetic characteristics of Coxsackievirus A6 strains isolated in Guangdong Province from year 2008 to 2013[J]. Chin J Microbiol Immunol, 2014, 34(10): 742-746. DOI: 10.3760/cma.j.issn.0254-5101.2014.10.003.
[8]	肖红, 管大伟, 曾汉日, 等. 2008-2009年广东手足口病非CA16非EV71肠道病毒株的鉴定及其VP1基因分型研究[J], 中华微生物和免疫学杂志, 2011, 31(9): 808- 812. DOI: 10.3760/cma.j.issn.0254-5101.2011.09.013 Xiao H, Guan DW, Zeng HR, et al. Genetic analysis of a partial VP1 region and molecular identification of non-EV71, non-CA16 virus strains of hand, foot and mouth disease(HFMD) in Guangdong Province between 2008 and 2009[J]. Chin J Microbiol Immunol, 2011, 31(9): 808- 812. DOI: 10.3760/cma.j.issn.0254-5101.2011.09.013
[9]	Osterback R, Vuorinen T, Linna M, et al. Coxsackievirus A6 and hand, foot, and mouth disease, Finland[J]. Emerg Infect Dis, 2009, 15(9): 1485-1488. DOI: 10.3201/eid1509.090438.
[10]	Mirand A, Henquell C, Archimbaud C, et al. Outbreak of hand, food and mouth disease/herpangina with Coxsackievirus A6 and A10 infections in 2010, France: a large citywide, prospective observational study[J]. Clin Microbiol Infect, 2012, 18(5): E110-E118. DOI: 10.1111/j.1469-0691.2012.03789.x.
[11]	蔡韵. 上海地区儿童手足口病流行与病原特征研究[D]. 上海: 复旦大学, 2013: 28-30. Cai Y. Epidemiology and etiology of HFMD in Shanghai[D]. Shanghai: Fudan university, 2013: 28-30.
[12]	Ooi EE, Phoon MC, Ishak B, et al. Seroepidemiology of Human Enterovirus 71, Singapore[J]. Emerg Infec Dis, 2002, 28(7): 37-42. DOI: 10.3201/eid0809.010397.
[13]	叶新, 何剑锋, 孙立梅, 等. 广州市3岁及以下儿童监护人肠道病毒71型认知及其灭活疫苗自费接种意愿调查[J]. 疾病监测, 2017, 32(3): 252-257. DOI: 10.3784/j.issn.1003-9961.2017.03.01. Ye X, He JF, Sun LM, et al. Awareness of Enterorirus 71 and willingness of self-paid Enterorirus type 71 in activated vaccine immunization inguardians of children aged ≤ 3 years in Guangzhou[J]. Dis Surveillance, 2017, 32(3): 252-257. DOI: 10.3784/j.issn.1003-9961.2017.03.01.