Association between MHC region and gastric cancer susceptibility in Han Chinese

LI Qian; YAN Cai-wang; JIN Guang-fu

doi:10.16462/j.cnki.zhjbkz.2021.09.002

Volume 25 Issue 9

Oct. 2021

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LI Qian, YAN Cai-wang, JIN Guang-fu. Association between MHC region and gastric cancer susceptibility in Han Chinese[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(9): 998-1002,1019. doi: 10.16462/j.cnki.zhjbkz.2021.09.002

Citation:

LI Qian, YAN Cai-wang, JIN Guang-fu. Association between MHC region and gastric cancer susceptibility in Han Chinese[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(9): 998-1002,1019. doi: 10.16462/j.cnki.zhjbkz.2021.09.002

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Association between MHC region and gastric cancer susceptibility in Han Chinese

doi: 10.16462/j.cnki.zhjbkz.2021.09.002

Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China

Funds:

National Natural Science Foundation of China 81872702

National Natural Science Foundation of China 82003534

National Natural Science Foundation of Jiangsu Province BK20200674

More Information

Corresponding author: JIN Guang-fu, E-mail: guangfujin@njmu.edu.cn
Received Date: 2021-08-13
Rev Recd Date: 2021-08-25

Available Online: 2021-10-23

Publish Date: 2021-09-10

Abstract

Abstract

Objective To investigate the association between genetic variants in the major histocompatibility complex (MHC) region and gastric cancer (GC) susceptibility. Methods Based on a case-control study, MHC region was imputed with SNP2HLA v1.0.3 software by using the Han-MHC database as a reference panel. Logistic regression analysis model was used to identify the independent genetic loci associated with GC susceptibility in the MHC region. Functional annotation of the MHC region was based on online public databases and performed to find the susceptibility gene and potential functional variants. Results We found that rs2517714 was the only independent association signal associated with GC risk in the MHC region (OR=1.13, P=2.70×10^-8). The results of functional annotation showed that HLA amino acid polymorphisms and single nucleotide polymorphisms (SNPs) located in the exon region of HLA-A may affect the stability of HLA-A protein. The SNP rs9295829 located in a non-coding region could remotely regulate the expression of HLA-A by affecting enhancer activity. Conclusion Functional genetic variations in the MHC region may affect the function of the susceptibility gene HLA-A to modulate GC susceptibility.
- Gastric cancer,
- Genome-wide association study,
- Fine mapping,
- Major histocompatibility complex,
- HLA-A

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References(25)

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