Joint effect of serum C-reactive protein and genetic risk in the pathogenesis of cancer

ZHU Meng-yi; WANG Tian-pei; YAN Cai-wang; ZHU Meng; JIN Guang-fu

doi:10.16462/j.cnki.zhjbkz.2021.09.004

Volume 25 Issue 9

Oct. 2021

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2021 > 25(9): 1008-1013

ZHU Meng-yi, WANG Tian-pei, YAN Cai-wang, ZHU Meng, JIN Guang-fu. Joint effect of serum C-reactive protein and genetic risk in the pathogenesis of cancer[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(9): 1008-1013. doi: 10.16462/j.cnki.zhjbkz.2021.09.004

Citation:

ZHU Meng-yi, WANG Tian-pei, YAN Cai-wang, ZHU Meng, JIN Guang-fu. Joint effect of serum C-reactive protein and genetic risk in the pathogenesis of cancer[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(9): 1008-1013. doi: 10.16462/j.cnki.zhjbkz.2021.09.004

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Joint effect of serum C-reactive protein and genetic risk in the pathogenesis of cancer

doi: 10.16462/j.cnki.zhjbkz.2021.09.004

Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China

Funds:

National Natural Science Foundation of China 81872702

National Natural Science Foundation of China 82003534

National Natural Science Foundation of Jiangsu Province BK20200674

More Information

Corresponding author: JIN Guang-fu, E-mail: guangfujin@njmu.edu.cn
Received Date: 2021-08-13
Rev Recd Date: 2021-08-24

Available Online: 2021-10-23

Publish Date: 2021-09-10

Abstract

Abstract

Objective To explore the joint effect of serum C-reactive protein (CRP) and genetic risk in the pathogenesis of cancer. Methods Based on UK Biobank data and the cancer polygenic risk score (CPRS) constructed previously, subjects were assigned into low, intermediate, and high genetic risk groups according to CPRS and were assigned into low, intermediate, and high groups based on natural logarithm of CRP. Cox proportional hazard model was used to test the association between serum CRP level and the risk of cancer in different genetic risk groups. Results A total of 420 940 subjects including 192 942 (45.84%) men and 227 998 (54.16%) women were included. The level of serum CRP was statistically associated with the risk of multiple cancers. High level of serum CRP was associated with an increased risk of overall cancer in male and female (male: HR=1.09, 95% CI: 1.07-1.11; female: HR=1.09, 95% CI: 1.07-1.11). The effect size of CRP on cancer risk was stronger in low genetic risk group (male: HR=1.38; female: HR=1.46) compared to that of high genetic risk group (male: HR=1.07; female: HR=1.17). There was a negative interaction between CRP and genetic risk in cancer. Conclusions High level of serum CRP can increase the cancer risk. Serum CRP level may have a stronger effect in low genetic risk population.
- Cancer,
- C-reactive protein,
- Polygenic risk score,
- Interaction

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References(19)

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