Association between vaccination and thrombocytopenic purpura: a case study of 13 cases

ZHONG Zhi-lei; SU Ting; ZHANG Shi-hong; CHEN Qiu-yu; MA Rui-lan; LI Qian; LI Jia-xuan; DONG Shao-zhong

doi:10.16462/j.cnki.zhjbkz.2021.09.005

Volume 25 Issue 9

Oct. 2021

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2021 > 25(9): 1014-1019

ZHONG Zhi-lei, SU Ting, ZHANG Shi-hong, CHEN Qiu-yu, MA Rui-lan, LI Qian, LI Jia-xuan, DONG Shao-zhong. Association between vaccination and thrombocytopenic purpura: a case study of 13 cases[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(9): 1014-1019. doi: 10.16462/j.cnki.zhjbkz.2021.09.005

Citation:

ZHONG Zhi-lei, SU Ting, ZHANG Shi-hong, CHEN Qiu-yu, MA Rui-lan, LI Qian, LI Jia-xuan, DONG Shao-zhong. Association between vaccination and thrombocytopenic purpura: a case study of 13 cases[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(9): 1014-1019. doi: 10.16462/j.cnki.zhjbkz.2021.09.005

Citation:

ZHONG Zhi-lei, SU Ting, ZHANG Shi-hong, CHEN Qiu-yu, MA Rui-lan, LI Qian, LI Jia-xuan, DONG Shao-zhong. Association between vaccination and thrombocytopenic purpura: a case study of 13 cases[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(9): 1014-1019. doi: 10.16462/j.cnki.zhjbkz.2021.09.005

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Association between vaccination and thrombocytopenic purpura: a case study of 13 cases

doi: 10.16462/j.cnki.zhjbkz.2021.09.005

Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming 650118, China

ZHONG Zhi-lei and SU Ting who contributed equally to this article

More Information

Corresponding author: DONG Shao-zhong, E-mail: dsz@imbcams.com.cn
Received Date: 2021-08-12
Rev Recd Date: 2021-08-20

Available Online: 2021-10-23

Publish Date: 2021-09-10

Abstract

Abstract

Objective The paper provides an analysis of 13 idiapathic thrombocytopenic purpura (ITP) cases after vaccination to discuss the causal association between vaccination and ITP, and the relevant measures to reduce the coincidental cases. Methods The paper sorts, describes and analyzes 13 cases of ITP after vaccination from Institute of Medical Biology, Chinese Academy of Medical Sciences during 2017-2020. Results Among 13 cases, 6 cases were irrelevant, 1 case was not likely irrelevant, 2 cases were not excluded, and 4 cases were probably related. Conclusions If ITP occurs after vaccination, infection factors should be excluded, and the time correlation between them should be analyzed a fair judgment of the causal association. It is suggested that the diagnostic criteria of ITP should be issued in time; the vaccination doctors should do a good job in health screening, so as to reduce the coincidental cases after vaccination as far as possible.
- Vaccination,
- Idiapathic thrombocyocytopenic purpura,
- Causality

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References(14)

References

[1]	崔清彦, 颉迎新, 王文欣, 等. 免疫性血小板减少症发病机制的研究进展[J]. 山东医药, 2020, 60(4): 102-105. DOI: 10.3969/j.issn.1002-266X.2020.04.027. Cui QY, Xie YX, Wang WX, et al. Research progress in the pathogenesis of immune thrombocytopenia[J]. Shandong Med J, 2020, 60(4): 102-105. DOI: 10.3969/j.issn.1002-266X.2020.04.027.
[2]	周萍, 唐吉斌. 免疫性血小板减少性紫癜的研究与进展[J]. 安徽医药, 2019, 23(3): 430-433. DOI: 10.3969/j.issn.1009-6469.2019.03.002. Zhou P, Tang JB. The progress and study of immune thrombocytopenic purpura[J]. Anhui Medical and Pharmaceutical Journal, 2019, 23(3): 430-433. DOI: 10.3969/j.issn.1009-6469.2019.03.002.
[3]	Basant Kumar Sah, 谢晓恬. 儿童免疫性血小板减少症发病机制与诊治研究进展[J]. 中国小儿血液与肿瘤杂志, 2017, 22(1): 51-54. DOI: 10.3969/j.issn.1673-5323.2016.06.011. Basant KS, Xie XT. Research progress in pathogenesis, diagnosis and treatment of immunological thrombocytopenia in children[J]. J China Pediatr Blood Cancer, 2017, 22(1): 51-54. DOI: 10.3969/j.issn.1673-5323.2016.06.011.
[4]	张建会. 病毒感染与原发免疫性血小板减少症的临床研究进展[J]. 临床医药实践, 2019, 28(6): 463-465. https://www.cnki.com.cn/Article/CJFDTOTAL-SXLC201906023.htm Zhang JH. Clinical research progress of viral infection and primary immune thrombocytopenia[J]. Proc Clin Med, 2019, 28(6): 463-465. https://www.cnki.com.cn/Article/CJFDTOTAL-SXLC201906023.htm
[5]	惠跃龙, 李金铖. 1例疫苗接种偶合特发性血小板减少性紫癜的处置及建议[J]. 海峡预防医学杂志, 2019, 25(3): 64-66. https://www.cnki.com.cn/Article/CJFDTOTAL-HXYF201903028.htm Hui YL, Li JC. Management and recommendations of a case of vaccine-coupled idiopathic thrombocytopenic purpura[J]. Strait J Prevent Med, 2019, 25(3): 64-66. https://www.cnki.com.cn/Article/CJFDTOTAL-HXYF201903028.htm
[6]	钱晓华, 杨彦基, 李跃, 等. 虹口区预防接种后血小板减少性紫癜4例案例分析[J]. 中国生物制品学杂志, 2018, 31(1): 59-61, 66. https://www.cnki.com.cn/Article/CJFDTOTAL-SWZP201801014.htm Qian XH, Yang YJ, Li Y, et al. Analysis on 4 cases of idiapathic thrombocytopenic purpura after vaccination in Hongkou District, Shanghai, China[J]. Chin J Biologicals, 2018, 31(1): 59-61, 66. https://www.cnki.com.cn/Article/CJFDTOTAL-SWZP201801014.htm
[7]	陈胜玉, 董晓莲, 陈颖峰, 等. 1例联合疫苗接种后偶合特发性血小板减少性紫癜病例调查与思考[J]. 中国疫苗和免疫, 2016, 22(3): 350-352. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGJM201603025.htm Chen SY, Dong XL, Chen YF. Investigation and consideration of a case of incidental idiopathic thrombocytopenic purpura after combined vaccination[J]. Chin J Vaccines Immun, 2016, 22(3): 350-352. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGJM201603025.htm
[8]	中华人民共和国全国人民代表大会常务委员会. 中华人民共和国疫苗管理法[EB/OL]. (2019-06-30)[2021-04-30]. http://www.gov.cn/xinwen/2019-06/30/content_5404540.htm. Standing Committee of the National People's Congress of the people's Republic of China. The Vaccine Administration Law of the People's Republic of China[EB/OL]. (2019-06-30)[2021-04-30]. http://www.gov.cn/xinwen/2019-06/30/content_5404540.htm.
[9]	王君霞, 郭林梅. 儿童疫苗相关性血小板减少性紫癜临床特点分析[J]. 西北国防医学杂志, 2018, 39(12): 803-806. DOI: 10.16021/j.cnki.1007-8622.2018.12.008. Wang JX, Guo LM. Analysis of clinical characteristics of children' s vaccination - related idiopathic thrombocytopenic purpura[J]. Med J NDFNC, 2018, 39(12): 803-806. DOI: 10.16021/j.cnki.1007-8622.2018.12.008.
[10]	O'Leary ST, Glanz JM, McClure DL, et al. The risk of immune thrombocytopenic purpura after vaccination in children and adolescents[J]. Pediatrics, 2012, 129(2): 248-255. DOI: 10.1542/peds.2011-1111.
[11]	CDC. VAERS reportable events table[EB/OL]. (2017-04-21)[2021-04-30]. https://vaers.hhs.gov/docs/VAERS_Table_of_Reportable_Events_Following_Vaccination.pdf.
[12]	Cook KM, Evans G. The National Vaccine Injury Compensation Program[J]. Pediatrics, 2011, 127 Suppl 1: S74-S77. DOI: 10.1542/peds.2010-1722K.
[13]	World Health Organization Regional Office for the Western Pacific. Immunization safety surveillance: guidelines for managers of immunization programmes on reporting and investigating adverse events following immunization[M]. Manila: World Health Organization, 1999.
[14]	国家卫生健康委. 预防接种异常反应补偿范围参考目录及说明(2020年版)的通知[EB/OL]. (2020-12-07)[2021-04-30]. http://www.nhc.gov.cn/cms-search/xxgk/getManuscriptXxgk.htm?id=58eb4a4b47694e5b81248b29cc315feb. General Office of NHC. Notice of reference catalogue and Description of compensation scope for Abnormal reaction to vaccination (2020 edition)[EB/OL]. (2020-12-07)[2021-04-30]. http://www.nhc.gov.cn/cms-search/xxgk/getManuscriptXxgk.htm?id=58eb4a4b47694e5b81248b29cc315feb.