Interaction between genetic variation and <i>Helicobacter pylori</i> infection in the occurrence of gastric cancer

REN Shuai; Li Qian; ZHU Meng-yi; ZHANG Yan; YAN Cai-wang; WEI Li-qin; JIN Guang-fu

doi:10.16462/j.cnki.zhjbkz.2021.09.008

Volume 25 Issue 9

Oct. 2021

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2021 > 25(9): 1034-1041

REN Shuai, Li Qian, ZHU Meng-yi, ZHANG Yan, YAN Cai-wang, WEI Li-qin, JIN Guang-fu. Interaction between genetic variation and Helicobacter pylori infection in the occurrence of gastric cancer[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(9): 1034-1041. doi: 10.16462/j.cnki.zhjbkz.2021.09.008

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REN Shuai, Li Qian, ZHU Meng-yi, ZHANG Yan, YAN Cai-wang, WEI Li-qin, JIN Guang-fu. Interaction between genetic variation and Helicobacter pylori infection in the occurrence of gastric cancer[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(9): 1034-1041. doi: 10.16462/j.cnki.zhjbkz.2021.09.008

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Interaction between genetic variation and Helicobacter pylori infection in the occurrence of gastric cancer

doi: 10.16462/j.cnki.zhjbkz.2021.09.008

1.
Department of Epidemiology, School of Public Health, Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014000, China
2.
Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China

Funds:

National Natural Science Foundation of China 81872702

National Natural Science Foundation of China 82003534

Natural Science Foundation of Jiangsu Province BK20200674

More Information

Corresponding author: WEI Li-qin,E-mail: wlqli1962@163.com; JIN Guang-fu,E-mail: guangfujin@njmu.edu.cn
Received Date: 2021-02-06
Rev Recd Date: 2021-03-23

Available Online: 2021-10-23

Publish Date: 2021-09-10

Abstract

Abstract

Objective To investigate the interaction between known genetic variation of gastric cancer and Helicobacter pylori (H. pylori) in the occurrence of gastric cancer, and its effect on tumor site and the age at onset of gastric cancer. Methods With a case-only design, the interaction between genetic variation and H. pylori was analyzed by binary Logistic regression analysis in 2 426 patients with gastric cancer. Results After adjusting confounding factors, the interactions of genetic variation NSUN 3 rs7624041 and DEFB rs 2376549 with H. pylori infection in gastric cancer were statistically significant (OR=1.257, 95% CI: 1.006-1.571, P=0.044; OR=0.845, 95% CI: 0.715-0.999, P=0.048). Based on the hierarchical analysis of tumor location, there was no interaction between genetic variation and H. pylori infection. Hierarchical analysis based on tumor stage showed that the interaction between lnc-POLR3G-4 rs7712641 and H. pylori infection was statistically significant in patient with early gastric cancer (OR=1.757, 95% CI: 1.060-2.915, P=0.029). The age-based stratified analysis results showed that the interactions between ASHIL rs80142782, NSUN 3 rs7624041, DEFB rs2376549 and H. pylori infection were statistically significant in people aged < 60 years (OR=1.602, 95% CI: 1.006-2.551, P=0.047; OR=1.811, 95% CI: 1.247-2.632, P=0.002; OR=0.688, 95% CI: 0.520-0.910, P=0.009). And the interactions between PSCA rs2294008, CUX 2 rs6490061 and H. pylori infection were statistically significant in people over 60 years old (OR=0.775, 95% CI: 0.630-0.954, P=0.016; OR=0.790, 95% CI: 0.635-0.982, P=0.034). Conclusions The occurrence and development of gastric cancer is complex. It is helpful to prevent the occurrence and development of gastric cancer by integrating genetic factors and environmental factors and taking targeted H. pylori eradication measures for susceptible and high-risk groups.
- Gastric cancer,
- Genetic variation,
- Helicobacter pylori,
- Case-only study,
- Interaction

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References(29)

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