Association between maternal exposure to phosphate fertilizers during pregnancy and the risk of preterm birth

ZHANG Yuan; LI Jia-jia; LIN Shi-qi; WU Ji-lei; PEI Li-jun

doi:10.16462/j.cnki.zhjbkz.2021.10.018

Volume 25 Issue 10

Nov. 2021

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ZHANG Yuan, LI Jia-jia, LIN Shi-qi, WU Ji-lei, PEI Li-jun. Association between maternal exposure to phosphate fertilizers during pregnancy and the risk of preterm birth[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(10): 1214-1219. doi: 10.16462/j.cnki.zhjbkz.2021.10.018

Citation:

ZHANG Yuan, LI Jia-jia, LIN Shi-qi, WU Ji-lei, PEI Li-jun. Association between maternal exposure to phosphate fertilizers during pregnancy and the risk of preterm birth[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(10): 1214-1219. doi: 10.16462/j.cnki.zhjbkz.2021.10.018

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Association between maternal exposure to phosphate fertilizers during pregnancy and the risk of preterm birth

doi: 10.16462/j.cnki.zhjbkz.2021.10.018

ZHANG Yuan^{1, 2},
LI Jia-jia¹,
LIN Shi-qi¹,
WU Ji-lei¹,
PEI Li-jun^{1
,
,}

1.
Institute of Population Research, Peking University, Center for Population Health and Development, Peking University, Beijing 100871, China
2.
National Research Institute for Health and Family Planning, Beijing 100081, China

Funds:

National Key Research and Development Program of China 2018YFC1004303

National Natural Science Foundation of China 41871360

Open Project of Key Laboratory of Birth Defect Prevention of National Health Commission, Henan ZD202002

More Information

Corresponding author: PEI Li-jun, E-mail: peilj@pku.edu.cn
Received Date: 2020-10-24
Rev Recd Date: 2021-01-28

Available Online: 2021-11-17

Publish Date: 2021-10-10

Abstract

Abstract

Objective To explore the association between consumption of chemical fertilizers and the risk of preterm birth, to provide references for improvement of birth outcomes. Methods Using the birth population monitoring data from October 1, 2007 to September 30, 2012 in Pingding County, Shanxi Province, 155 cases of preterm birth were followed up, and 204 newborns with normal birth weight (2 500~4 000 g) born at the same time without any surface defects and gestational age ≥37 weeks were randomly selected as the control group. Stratified multivariate Logistic regression model and structural equation model were used to investigate the associations between the risk of preterm birth and maternal exposure to chemical fertilizers during pregnancy. Results The results of the stratified multivariate Logistic regression analysis model showed that after adjusting for confounding factors, women exposed to village-level fertilizer application ≥100 t had a higher risk of preterm birth than women who had village-level fertilizer application < 50 t (aOR=2.51, 95% CI: 1.23-5.12). Household consumption of phosphorus fertilizer was a risk factor for premature birth (aOR=2.54, 95% CI: 1.23-5.22). The findings of structural equation model indicated that maternal exposure to phosphate fertilizer during pregnancy may be an important environmental factor for the risk of premature birth. Conclusions Women's exposure to chemical fertilizers during pregnancy, especially phosphate fertilizers, is associated with the risk of preterm birth, so it is recommended that rural women should try to avoid exposure to chemical fertilizers during pregnancy.
- Preterm birth,
- Chemical fertilizer,
- Phosphate,
- Pregnancy,
- Women,
- Association

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References(15)

References

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