Relationship between creatinine clearance rate and simple renal cysts: a nested case-control study

MA Zhi-bin; QUAN Pei-qin; YANG Chao; DOU Feng; DU Hong-mei; LI Jian-jian; ZHAO Yi-ni; BAI Ya-na; REN Xiao-wei; HU Xiao-bin

doi:10.16462/j.cnki.zhjbkz.2022.11.013

Volume 26 Issue 11

Nov. 2022

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2022 > 26(11): 1315-1320

MA Zhi-bin, QUAN Pei-qin, YANG Chao, DOU Feng, DU Hong-mei, LI Jian-jian, ZHAO Yi-ni, BAI Ya-na, REN Xiao-wei, HU Xiao-bin. Relationship between creatinine clearance rate and simple renal cysts: a nested case-control study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(11): 1315-1320. doi: 10.16462/j.cnki.zhjbkz.2022.11.013

Citation:

MA Zhi-bin, QUAN Pei-qin, YANG Chao, DOU Feng, DU Hong-mei, LI Jian-jian, ZHAO Yi-ni, BAI Ya-na, REN Xiao-wei, HU Xiao-bin. Relationship between creatinine clearance rate and simple renal cysts: a nested case-control study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(11): 1315-1320. doi: 10.16462/j.cnki.zhjbkz.2022.11.013

Citation:

MA Zhi-bin, QUAN Pei-qin, YANG Chao, DOU Feng, DU Hong-mei, LI Jian-jian, ZHAO Yi-ni, BAI Ya-na, REN Xiao-wei, HU Xiao-bin. Relationship between creatinine clearance rate and simple renal cysts: a nested case-control study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(11): 1315-1320. doi: 10.16462/j.cnki.zhjbkz.2022.11.013

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Relationship between creatinine clearance rate and simple renal cysts: a nested case-control study

doi: 10.16462/j.cnki.zhjbkz.2022.11.013

Department of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou 730000, China

Funds:

Natural Science Foundation of Gansu Province 20JR10RA599

More Information

Corresponding author: HU Xiao-bin, E-mail: huxiaobin@lzu.edu.cn
Received Date: 2021-12-27
Rev Recd Date: 2022-03-23

Available Online: 2022-12-21

Publish Date: 2022-11-10

Abstract

Abstract

Objective To explore the correlation between baseline creatinine clearance rate (Ccr) and follow-up of simple renal cysts (SRCs) in Jinchang cohort population, and to provide a scientific basis for the prevention and treatment of SRCs. Methods Based on the Jinchang cohort, nested case control method was used in this study, the subjects included 859 cases of SRCs and 859 controls matched according to follow-up time, age, gender and hypertension. The association between baseline Ccr and follow-up of SRCs was analyzed by univariate and multivariate conditional logistic regression models respectively, and the OR with 95% CI values were calculated. Then the dose-response relationship between baseline Ccr and follow-up of SRCs was analyzed by using restrictive cubic spline. Results After adjusting for confounding variables, compared to the interval with baseline Ccr higher than 80.00 mL·min^-1·1.73m^-2, the result of multivariate conditional logistic regression showed that the risk of SRCs in the interval with baseline Ccr lower than 60.00 mL·min^-1·1.73m^-2 and interval with baseline Ccr between 60.00- < 70.00 mL·min^-1·1.73m^-2 was 2.10 times [95% CI: 1.13-3.89)], and 1.57 times [95% CI: 1.03-2.39)], respectively. The results of restricted cubic spline showed that there was an inverse nonlinear dose-response relationship between baseline Ccr and follow-up of SRCs in the Jinchang cohort population. Conclusions Low creatinine clearance is an independent risk factor for SRCs, and when the baseline Ccr was lower than 80.00 mL·min^-1·1.73m^-2, the risk of SRCs in the Jinchang cohort population increased with the decrease of Ccr.
- Creatinine clearance rate,
- Simple renal cysts,
- Nested case control study

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References(19)

References

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