A prospective cohort study on the association of maternal perinatal cigarette smoking, alcohol consumption and their interactions with risk of neonatal low birth weight

PENG Yuan; LUO Manjun; RUAN Xiaorui; LI Liuxuan; LIU Hanjun; TANG Jiapeng; QIN Jiabi

doi:10.16462/j.cnki.zhjbkz.2024.11.003

Volume 28 Issue 11

Nov. 2024

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PENG Yuan, LUO Manjun, RUAN Xiaorui, LI Liuxuan, LIU Hanjun, TANG Jiapeng, QIN Jiabi. A prospective cohort study on the association of maternal perinatal cigarette smoking, alcohol consumption and their interactions with risk of neonatal low birth weight[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(11): 1257-1263. doi: 10.16462/j.cnki.zhjbkz.2024.11.003

Citation:

PENG Yuan, LUO Manjun, RUAN Xiaorui, LI Liuxuan, LIU Hanjun, TANG Jiapeng, QIN Jiabi. A prospective cohort study on the association of maternal perinatal cigarette smoking, alcohol consumption and their interactions with risk of neonatal low birth weight[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(11): 1257-1263. doi: 10.16462/j.cnki.zhjbkz.2024.11.003

Citation:

PENG Yuan, LUO Manjun, RUAN Xiaorui, LI Liuxuan, LIU Hanjun, TANG Jiapeng, QIN Jiabi. A prospective cohort study on the association of maternal perinatal cigarette smoking, alcohol consumption and their interactions with risk of neonatal low birth weight[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(11): 1257-1263. doi: 10.16462/j.cnki.zhjbkz.2024.11.003

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A prospective cohort study on the association of maternal perinatal cigarette smoking, alcohol consumption and their interactions with risk of neonatal low birth weight

doi: 10.16462/j.cnki.zhjbkz.2024.11.003

Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410013, China

Funds:

National Natural Science Foundation of China 82073653

National Natural Science Foundation of China 81803313

Hunan Provincial Foundation for Distinguished Young Scholars 2022JJ10087

More Information

Corresponding author: QIN Jiabi, E-mail: qinjiabi123@163.com
Received Date: 2024-04-26
Rev Recd Date: 2024-08-05

Available Online: 2024-12-23

Publish Date: 2024-11-10

Abstract

Abstract

Objective To assess the effects of maternal cigarette smoking and alcohol consumption and their interactions during periconceptional pregnancy on the risk of low birth weight (LBW) in newborns. Methods Pregnant women attending their initial early prenatal care in Hunan Province were recruited to establish a cohort. Information was collected through questionnaires and medical records, with telephone follow-ups to monitor pregnancy outcomes including LBW. The logistic regression analysis was applied to assess the associations of maternal periconceptional cigarette smoking, alcohol consumption, and their interactions with the risk of LBW. Meanwhile, stratified analysis was conducted to evaluate the stability of the associations. Results A total of 34 104 singleton pregnancies and newborns were included in this study. Among these newborns, 3 020 cases were diagnosed with LBW, with an incidence of 8.9% (95% CI: 8.6%-9.2%). The multivariate logistic regression analysis showed that maternal active smoking (OR=1.428, 95% CI: 1.147-1.777), passive smoking (OR=1.128, 95% CI: 1.031-1.235), and alcohol consumption (OR=2.297, 95% CI: 1.949-2.706) during periconceptional pregnancy were significantly associated with risk of LBW (all P < 0.05). Additionally, the interaction analysis revealed an antagonistic effect between active smoking and alcohol consumption (OR=0.117, 95% CI: 0.049-0.278). Conclusions Maternal periconceptional active smoking, passive smoking, alcohol consumption and their interactions are significantly associated with neonatal LBW, highlighting the importance of maintaining healthy behaviors during pregnancy to prevent LBW.
- Low birth weight,
- Cigarette smoking,
- Alcohol consumption,
- Interaction,
- Prospective cohort study

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References(23)

References

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