The mediating effect of Th1/Th2 balance deviation in the association between B[a]P intrauterine exposure and embryonic arrest

LI Fuxing; LIU Sha; ZHANG Jiayu; JI Jingru; WU Yanfei; Cao Jiuru; WEI Junni

doi:10.16462/j.cnki.zhjbkz.2024.11.004

Volume 28 Issue 11

Nov. 2024

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LI Fuxing, LIU Sha, ZHANG Jiayu, JI Jingru, WU Yanfei, Cao Jiuru, WEI Junni. The mediating effect of Th1/Th2 balance deviation in the association between B[a]P intrauterine exposure and embryonic arrest[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(11): 1264-1269. doi: 10.16462/j.cnki.zhjbkz.2024.11.004

Citation:

LI Fuxing, LIU Sha, ZHANG Jiayu, JI Jingru, WU Yanfei, Cao Jiuru, WEI Junni. The mediating effect of Th1/Th2 balance deviation in the association between B[a]P intrauterine exposure and embryonic arrest[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(11): 1264-1269. doi: 10.16462/j.cnki.zhjbkz.2024.11.004

Citation:

LI Fuxing, LIU Sha, ZHANG Jiayu, JI Jingru, WU Yanfei, Cao Jiuru, WEI Junni. The mediating effect of Th1/Th2 balance deviation in the association between B[a]P intrauterine exposure and embryonic arrest[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(11): 1264-1269. doi: 10.16462/j.cnki.zhjbkz.2024.11.004

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The mediating effect of Th1/Th2 balance deviation in the association between B[a]P intrauterine exposure and embryonic arrest

doi: 10.16462/j.cnki.zhjbkz.2024.11.004

1.
Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China
2.
Department of Obstetrics, The First Hospital of Shanxi Medical University, Taiyuan 030001, China

Funds:

Shanxi Provincial Basic Research Project 201901D111206

Shanxi Provincial Health Commission Scientific Research Project 2020086

More Information

Corresponding author: WEI Junni, E-mail: junni.wei@sxmu.edu.cn
Received Date: 2023-11-03
Rev Recd Date: 2024-04-18

Available Online: 2024-12-23

Publish Date: 2024-11-10

Abstract

Abstract

Objective To investigate the association between exposure to benzo [a] pyrene (B[a]P) and embryonic arrest, and the mediating effects of helper T cell 1/helper T cell 2(Th1/Th2) balance deviation. Methods A total of 245 women with embryonic arrest and women with normal pregnancy who voluntarily induced abortion were selected as the study objects. The levels of 7, 8-dihydroxy-9, 10-epoxy-benzo [a] pyrene (BPDE)-DNA adducts and interleukin (IL)-2, interferon-γ(IFN-γ), IL-4, IL-10 in villus tissues were detected. Logistic regression model was used to analyze the correlation between B[a]P exposure and embryonic arrest, and Bootstrap method was used to analyze the mediating effect of Th1/Th2 balance deviation between them. Results After adjusting for covariates, it was found that the risk of embryonic arrest at medium-high exposure level and high exposure level of BPDE-DNA adducts was 5.66 times (aOR=5.66, 95% CI: 2.00-16.01, P < 0.001) and 5.63 times(aOR=5.63, 95% CI: 1.97-16.14, P < 0.001) higher than that at low exposure level, respectively; The results of mediating analysis showed that B[a]P had a total effect of 1.220 (0.501-1.939) on embryonic arrest, with a mediating effect caused by Th1/Th2 balance deviation of 0.328 (0.078-0.716), accounting for 26.89%. Conclusions B[a]P exposure is a risk factor for embryonic arrest, and Th1/Th2 imbalance occurring with a Th1-Type deviation is a mediating variable of embryonic arrest caused by B[a]P exposure.
- Benzo [a] pyrene,
- Embryonic arrest,
- Helper T cell 1/helper T cell 2,
- Balance deviation,
- Mediating effect

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References(18)

References

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