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CN 34-1304/R ISSN 1674-3679

2018 Vol. 22, No. 11

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Advance in epidemiologic studies on major autoimmune diseases
PAN Hai-feng, LENG Rui-xue, WU Guo-cui, YE Dong-qing
2018, 22(11): 1093-1095,1105. doi: 10.16462/j.cnki.zhjbkz.2018.11.001
Abstract(1775) PDF(275)
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The major spectrum of autoimmune diseases includes systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), etc. The exact etiology and pathogenesis of autoimmune diseases are still not fully elucidated, and the prevalence of autoimmune diseases are increasing in the recent years, greatly influencing the patient's labor and life quality, consuming a large amount of health resources and becoming an important public health problem. In the field of public health and preventive medicine, there are disproportionate attention to the tumor, diabetes and digestive diseases, whereas the studies on major autoimmune diseases are very limited. Therefore, prospective studies on autoimmune diseases should be carried out to elucidate the risk factors, assess the risk and promote the accurate prevention of diseases. The discovery of disease-causing genes, early warning and early diagnosis have become urgent problems for the prevention and control of autoimmune diseases. This article will provide a brief overview of the advance in epidemiological studies on two types of major autoimmune diseases, SLE and RA.
Analysis on dietary pattern and its influencing factors among residents in a district of Beijing
FAN Xin-yi, WEI Shao-ming, ZHANG Jian, ZHANG Yu-mei, SHI Yu-hui
2018, 22(11): 1096-1100. doi: 10.16462/j.cnki.zhjbkz.2018.11.002
Abstract(797) PDF(86)
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Objective To investigate the dietary pattern and its influencing factors among residents in a district of Beijing. Methods Using multi-stage stratified random sampling method, residents aged 18-79 years old were recruited in the survey. Food frequency questionnaire (FFQ) was used for dietary intake, and the dietary patterns were defined by factor analysis.Multinomial regression Logistic models were performed to determine the influencing factors of different dietary patterns. Results There were 5 dietary patterns derived from 3 624 residents, which were named as pattern of "meat", "juice and beverages", "alcohol and staple", tradition and "egg and diary". Single factor analysis showed that residents dietary patterns were associated with their educational level, gender, age and occupation (all P<0.05). Multinomial Logistic regression analysis results showed that "meat" pattern was positively associated with educational level(P=0.003, OR=1.841, 95% CI:1.234-2.748) while negatively with female(P<0.001, OR=0.428, 95% CI:0.315-0.582),"juice and beverages"pattern negatively with age (P<0.001, OR=0.946, 95% CI:0.932-0.961), female(P=0.020, OR=0.694, 95% CI:0.510-0.943) and diabetes patients (P=0.013, OR=0.456, 95% CI:0.246-0.846),"alcohol and staple" pattern negatively with female (P<0.001, OR=0.083, 95% CI:0.058-0.118) while positively with physical laborers (P=0.027, OR=1.529, 95% CI:1.050-2.228),traditional pattern negatively with students (P=0.027, OR=0.091, 95% CI:0.011-0.765) while positively with those who lived with other family members (P=0.005, OR=1.636, 95% CI:1.160-2.305),"egg and diary" pattern positively with age (P<0.001, OR=1.036, 95% CI:1.021-1.051), female (P<0.001, OR=1.922, 95% CI:1.414-2.612) and educational level (P<0.001, OR=2.598, 95% CI:1.759-3.837). Conclusions Dietary patterns of the residents were associated with age, gender, educational level and occupations. Targeted nutritional interventions should be provided based on their specific dietary behavior and patterns.
Analysis of incidence and mortality rates of brain and nervous system cancer in registration areas of China from 2008 to 2012
ZHA Zhen-qiu, LIU Zhi-rong, ZHENG Rong-shou, CHEN Wan-qing, YE Dong-qing
2018, 22(11): 1101-1105. doi: 10.16462/j.cnki.zhjbkz.2018.11.003
Abstract(514) PDF(61)
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Objective To describe the incidence and mortality rates of brain and nervous system cancer in 135 cancer registration areas of China from 2008 to 2012. Methods The pooled data from 135 cancer registration areas in China from 2008 to 2012 were collected, and the incidence and mortality rates of brain and nervous system cancer were calculated. Results The overall incidence rate of brain and nervous system cancer in 135 registration areas was 6.21/100 000, and age-standardized rate by Chinese standard population (ASR China) and age-standardized rate by Segi's world population(ASR world) were 3.93/100 000 and 3.87/100 000 respectively, accounting for 2.19% of whole cancer and being ranked as the eleventh common cancer in China. The crude cancer incidence of brain and nervous system and ASR China were 9.45/100 000 and 6.31/100 000 for males compared with 2.88/100 000 and 1.72/100 000 for females, respectively. The brain and nervous system cancer incidence and ASR China were 7.59/100 000 and 4.60/100 000 in urban areas, while 4.07/100 000 and 2.78/100 000 in rural areas, respectively. The crude mortality in China was 2.48/100 000 (male 3.71/100 000, female 1.21/100 000), age-standardized mortality by Chinese standard population and by world standard population were both 1.40/100 000,and being ranked as the twelfth among the causes of death of various common cancer in China. The crude cancer mortality of brain and nervous system and ASR China were 2.91/100 000 and 1.53/100 000 in urban areas compared with 1.81/100 000 and 1.16/100 000 in rural areas, respectively. Conclusions Brain and nervous system cancer is one of the most common life-threatening cancers in China. The incidence rate of brain and nervous system cancer in urban areas is higher than that in rural areas of China, which is also higher in males than in females. The prevention and control for brain and nervous system cancer must be strengthened.
The trend of coronary heart disease mortality and disease burden among rural area of Liaoning Province from 2009 to 2015
AI Cong, LI Juan, ZHANG Shan-shan, LIU Xiao-bing, SUN Qiu-hong, SHI Jing-pu
2018, 22(11): 1106-1109. doi: 10.16462/j.cnki.zhjbkz.2018.11.004
Abstract(440) PDF(39)
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Objective To explore the trend of coronary heart disease(CHD) mortality and disease burden among Zhangwu and Fengcheng rural areas of Liaoning Province. Methods The all-cause mortality data and the demographic data of Zhangwu and Fengcheng areas in Liaoning Province from 2009 to 2015 were collected. Mortality, age standardized mortality, years of life lost (YLLs), YLL rate, age standardized YLL rate, average years of life lost (AYLLs), age standardized AYLLs and the change of all indexes with year were calculated. Results The maximum value of mortality was 159.34 per 100 000 among rural area of Liaoning Province in 2015. The mortality of CHD was positively correlated with time at a speed of 5.51% (rs=0.964, P<0.001). YLLs for male and population were positively correlated with time and increased with years at a speed of 5.15% and 4.25% respectively (all P<0.05), but age standardized YLL rate and AYLLs for female were negatively correlated with time and decreased with years at a speed of 5.66% and 1.65% respectively (all P<0.05). Conclusions There was a growing tendency of the mortality and YLL rate of CHD among rural areas of Liaoning from 2009 to 2015, and it brought burdens to people there. It is necessary to carry out health education about CHD and take further measures to prevent CHD.
A comparative analysis of disease burden among adolescents in Jiangsu in 2003 and 2016
FAN Zhou-quan, LUO Peng-fei, SU Jian, YU Hao, CHEN Yi-jia, HAN Ren-qiang, ZHOU Jin-yi, WU Ming
2018, 22(11): 1110-1114. doi: 10.16462/j.cnki.zhjbkz.2018.11.005
Abstract(437) PDF(46)
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Objective To analyze the disease burden and its changes of adolescents in Jiangsu Province in 2003 and 2016, and to provide scientific basis for the health promotion of adolescents. Methods Death data of 2013 and 2016 were collected from The Third Death Retrospective Survey and The Death Registration System in Jiangsu, respectively. Indicators of disease burden including mortality, years of life lost (YLL) etc. were calculated. Results In 2003 and 2016, the number of youth deaths in Jiangsu Province was 5 025 and 2 222, respectively, with age-standardized mortality rate decreased by 16.04%. Corresponding YLL was 357 461 person-years and 156 932 person-years respectively, and the age-standardized YLL rate decreased by 36.36%. In 2016, the top five causes of death among adolescents in Jiangsu Province were road injuries, drowning, suicide and its sequelae, leukemia, accidental fall, among which, accidental fall rose from the 9th in 2003 to the 5th in 2016. We also found that the proportion of youth deaths of chronic non-communicable diseases has rapidly increased, especially for female adolescents, the proportion has exceeded injury both in 2003 and 2016. The causes of death varied in different age groups, the first leading cause of deaths was drowning and road injuries in the age group of 10-14 and 15-24, respectively. Conclusions Compared with 2003, the disease burden of adolescents in Jiangsu Province has decreased significantly in 2016. While for health promotion among adolescents, relevant measures should be taken according to the disease burden among different genders and ages.
Effects of leucine intervention on body compositions, blood glucose and blood lipids in patients with type 2 diabetes mellitus with overweight/obesity
ZHANG Jian-wei, LI Wei, TONG Xing, CHEN Lei, WANG Li, XU Jia-ying, QIN Li-qiang
2018, 22(11): 1115-1118. doi: 10.16462/j.cnki.zhjbkz.2018.11.006
Abstract(436) PDF(35)
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Objective To investigate the effects of leucine on body compositions, blood glucose and blood lipids in overweight/obese adult with type 2 diabetes mellitus, so as to provide the evidence for diabetic dietary therapy. Methods Thirty-four patients without insulin therapy were randomly divided into leucine intervention group and control group. The participants in the intervention group received 3 g of leucine per day. The study was lasted 3 months and the participants maintained their therapy and life style. The relative parameters were determined before and after the study. Results Thirty participants (15 in the intervention group and 15 in the control group) completed the study. There was no significant difference in body compositions, blood glucose and lipids between two groups at baseline. After intervention, the body weight decreased by 0.91 kg and 0.83 kg, and body protein increased by 0.17 kg and 0.30 kg in intervention group and control group, respectively. On the other hand, the fasting blood glucose decreased by 0.37 mmol/L in the intervention group and increased by 0.12 mmol/L in the control group. However, there were no significant differences in body weight, fat mass, muscle mass between the control and intervention groups. In addition, the plasma levels of fasting blood glucose, glycosylated hemoglobin and blood lipids were similar between two groups. Little change of these parameters was observed before and after the study. Conclusion Leucine supplementation of 3 g/day for 3 months has no effects on body compositions, blood glucose and blood lipids in overweight/obese adult with type 2 diabetes mellitus.
The influence of the interaction of SLC2A9 gene and BMI on hyperuricemia by crossover analysis
ZHAO Yuan, REN Yang-jie, WEN Jing, ZHAO Li, ZHANG Ya-di, GUO Zhong-qin
2018, 22(11): 1119-1122,1133. doi: 10.16462/j.cnki.zhjbkz.2018.11.007
Abstract(515) PDF(51)
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Objective To explore the influence of interaction of SLC2A9 gene rs1014290 and rs7442295 and body mass index (BMI) on hyperuricemia in Ningxia so as to provide evidences for the etiology of hyperuricemia. Methods 366 subjects identified by regular physical examination in a certain medical institution were selected as case group,meanwhile, 366 subjects were selected as control group by 1:1 pairing according to gender, ethnicity and age. The crossover analysis was used to analyze the interaction relationship between genetic polymorphisms of rs1014290, rs7442295 and BMI in hyperuricemia population. Results The difference of creatinine, total cholesterol, triglyceride, BMI and systolic blood pressure between case group and control group were statistically significant (P<0.05), and the case group was slightly higher than the control. The genotypes of rs1014290 were statistically significant (χ2=13.117, P=0.004). The genotypes of different genetic models at rs1014290 were statistically significant (χ2=11.225, P=0.001). The morbidity of hyperuricemia in GG genotype was 47.4% of the cases with hyperuricemia in GA + AA genotype. In the crossover analysis of rs1014290 and BMI, the additive model had statistical significance (U=4.874, P=0.032), S=-2.022, AP=0.674, AP*=1.495, RERI=1.227. There was statistical significance based on the multiplicative model (P=0.017),ORint=4.123. Conclusion There is an additive interaction and multiplicative interaction between rs1014290 and BMI.
Dose-response relationship between shift work and hyperuricemia
ZHANG Sheng-kui, WANG Zhen-de, YANG Li, ZHANG Le-yan, WANG Yong-bin, YUAN Ju-xiang
2018, 22(11): 1123-1127. doi: 10.16462/j.cnki.zhjbkz.2018.11.008
Abstract(664) PDF(44)
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Objective To explore the dose-response relationship between weighted shift index (WSI) and hyperuricemia (HUA) in steel workers. Methods A total of 7 617 steel workers were interviewed with a standardized questionnaire and physically examined. We analyzed the cross-sectional relationship between WSI and HUA by restrictive cubic spline (RCS) model, and the potential confounders by multi-factor Logistic regression model. Results Among participants, 36.2% of the individuals had hyperuricemia (37.5% in males and 20.9% in females). After adjusting for age, gender, smoking, drinking, diet, physical activity, sleep duration, sleep quality, monthly family income per capita, education, and health status, RCS model illustrated a nonlinear dose-response relationship between WSI and HUA in steel workers (χ2=30.51, P<0.001 for overall association test and χ2=29.71, P<0.001 for nonlinear test). Conclusions There is a nonlinear dose-response relationship between WSI and HUA in steel workers.
Characterization of Mycobacterium tuberculosis isolates from Henan Province by genotyping and drug susceptibility tests
SHI Jie, ZHENG Dan-wei, ZHU Yan-kun, MA Xiao-guang, WANG Shao-hua, LI Hui, ZHANG Guo-long
2018, 22(11): 1128-1133. doi: 10.16462/j.cnki.zhjbkz.2018.11.009
Abstract(553) PDF(45)
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Objective To explore the genetic profile of tuberculosis from Henan. Methods 668 MTB isolates from various areas during 2015 were genotyped with spoligotyping and 26-locus mycobacterium interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) (classical 24-locus MIRU-VNTR and 2 other loci). The association between tuberculosis spoligotype signatures and drug-resistant profiles was analyzed. Results Spoligotyping data revealed 668 isolates were grouped into 10 different clusters. Beijing family was the most predominant genotype in Henan. There was no correlation between Beijing family and gender, age at diagnosis and treatment history, however, Beijing family had a higher proportion of resistance to all four first-line drug and multidrug-resistant phenotypes. 668 isolates were divided into 567 different types by 26-locus MIRU-VNTR analysis. For these samples, 15 of 26 MIRU-VNTR loci had highly or moderately discriminatory power according to the Hunter-Gaston discriminatory index. A combination of the 10 most polymorphic loci acquired similar discriminatory power to that of 26-locus set. Conclusions Beijing genotype is the most prevalent family. 10-locus MIRU-VNTR in combination with spoligotyping can efficiently investigate evolutionary genetics of MTB in Henan Province.
Study on epidemic characteristics, temporal and spatial variations of gonorrhea in one city in China from 2005 to 2016
ZHA Wen-ting, ZOU Xiang-yu, YI Shang-hui, HUANG Zhu-lin, HE Qi-can, LIU Ying, LÜ Yuan
2018, 22(11): 1134-1137,1159. doi: 10.16462/j.cnki.zhjbkz.2018.11.010
Abstract(435) PDF(28)
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Objective To explore the epidemic characteristics, along with the temporal and spatial variations of gonorrhea in one city in China from 2005 to 2016 so as to provide scientific basis for the optimal allocation of health resources and prevention of gonorrhea. Methods All data used was from the information reporting management system of the Chinese Center for Disease Control and Prevention. The data used included the incidence and three distribution features that were analyzed for the epidemic characteristics of gonorrhea, the dynamic sequence and estimating average percent change that were analyzed for temporal variations, along with the matic map and the hot spot map in GIS that were analyzed for spatial variation. Results There were 10 842 patients who contracted gonorrhea in one city in China from 2005 to 2016, while the average incidence rate was 13.80/100 000. In patients, the ratio of male to female was 2.12:1, 63.17% of them aged from 20 to 39 years, the major occupations of them were farmers (31.51%), unemployed (13.00%), business or service people(12.04%). The average development speed of gonorrhea was 97.86%, the average growth rate was -2.14%, and the annual estimated differentiation was -5.16%, the change was stable. The relatively high incidence of gonorrhea was observed in Yuelu District (22.65/100 000), Rainflower District (20.31/100 000) and Furong District (18.24/100 000), Ningxiang (24.33%), Liuyang (15.57%), Yuelu (14.57%) and Yuelu districts(12.99%) occupied a higher constituent ratio of patients, Ningxiang and Liuyang showed high incidence of gonorrhea from 2005 to 2016. Conclusion The average incidence of gonorrhea in the city was slightly higher than the average incidence in China, but showed a steady negative growth from the year 2005 to 2016, we should pay attention to the key areas (Ningxiang, Liuyang, Yuhua and Yuelu District), the key population(from 20 to 39 years old; male; farmer, housekeeping, business or service people), to create a social environment for the prevention of sexually transmitted diseases together.
Epidemiological characteristics and temporal-spatial clustering analysis of severe hand-foot-mouth disease in Nanjing from 2009 to 2016
MA Tao, XIE Guo-xiang, SUN Hong-min, XU Qing, FENG Luo-ju, XU Yang-ting, SUI Hai-tian, LIN Dan, ZHANG Min
2018, 22(11): 1138-1143. doi: 10.16462/j.cnki.zhjbkz.2018.11.011
Abstract(420) PDF(57)
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Objective To analyze epidemiological characteristics of hand-foot-mouth disease (HFMD) in Nanjing, and to explore the temporal and spatial clustering, in order to provide decision making strategy for control and prevention of severe HFMD. Methods Descriptive epidemiologic methods were used to analyze severe HFMD data in Nanjing during 2009-2016 from the Chinese Disease Surveillance Information Reporting System. Time-space rescheduling scanning analysis was used to explore spatial characteristics. Results A total of 1 526 severe HFMD cases were reported in Nanjing from 2009 to 2016, the annual average cases was 191(93 to 284). The proportion of severe HFMD was 11‰ (6‰-20‰) and there was no significant change in the tendency (Z=-1.5, P=0.125). The reported incidence rate for population ≤ 5 years old was 53/100 000 (21/100 000 to 76/100 000). The peak time was April to July (54%) in each year. The proportion of male cases was 64%. The median age was 2 (0-13) years. The proportion of cases aged under 5 years was 97%, in which cases aged 1-3 years was 75%. The proportion for scattered children was 67% and for preschool children was 31%. The temporal and spatial clustering existed among severe HFMD cases between 2009 and 2016 except for 2013, which was shifting to the south of the city, including Jiangning, Yuhuatai and Lishui, from the centre. The temporal dimension of severe HFMD was from March to July in each year (all P<0.001). The positive rate of Enterovirus for severe HFMD cases was 39% (17%~70%). The proportion of EV71 and CoXA16 were 75% (54%-89%) and 5% (0-17%), respectively. Conclusions Epidemiological characteristics of severe HFMD cases were consistent with common cases in Nanjing. EV71 was the main pathogen which caused the severe cases. Monitoring among high risk areas and populations and the EV71 vaccination are essential measures.
Analysis of distribution characteristics and prediction model of hepatitis A incidence based on spatiotemporal big data
ZHU Jia-jia, HU Deng-li, HONG Xiu-qin, ZHA Wen-ting, LÜ Yuan
2018, 22(11): 1144-1147. doi: 10.16462/j.cnki.zhjbkz.2018.11.012
Abstract(720) PDF(46)
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Objective To understand the spatiotemporal distribution of hepatitis A incidence in China, and to assess the feasibility of ARIMA product season model in the prediction of hepatitis A incidence. Methods Data about hepatitis A incidence and demography from 2006 to 2017 were collected, spatiotemporal distribution diagram of hepatitis A incidence was drawn by using MapInfo 11.0, and ARIMA model for the 2006-2016 incidence series was established by using SPSS 23.0. Data of 2017 incidence were used to evaluate the prediction accuracy of the model. Results In 2006-2016, a total of 430 962 cases of hepatitis A were reported nationwide, the incidence declined with each passing year, and the western was significantly higher than the eastern region. The optimal model ARIMA(0, 2, 2)(0, 1, 1)12 was established after data smoothing, leveling, parameter estimation and model test.The prediction results of hepatitis A incidence were roughly consistent with the observations in 2017, and the relative error was between 2.0% and 39.7%. Conclusions The incidence of hepatitis A has been decreasing by years and shown significant differences between the eastern and western regions in China. The ARIMA product season model is suitable for forecasting the hepatitis Aincidence in short-term.
The sexual disparity and determinants of depressive symptoms among the rural elderly in China
WANG Li, ZHANG Xiao
2018, 22(11): 1148-1151. doi: 10.16462/j.cnki.zhjbkz.2018.11.013
Abstract(657) PDF(68)
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Objective To investigate the sexual disparity and determinants of depression among the rural elderly in China, so as to provide evidences narrowing the disparity of depression and promoting health equity in elderly population. Methods China health and retirement longitudinal study (CHARLS) dataset of 2015, Fairlie decomposition was adopted to analyze the disparity in depression between the male and femal elderly. Results The prevalence of depression among the rural elderly was 39.09%, and the prevalence of depression in women was higher than that in men (47.82% vs 32.43%, χ2=97.05,P<0.001). Logistic regression analyses demonstrated that region, sleep length,daily activity,self-rated health and pain were the common factors affecting the the prevalence of depression among men and women, while marital status and social activity were the factors affecting the prevalence of depression among men.Fairlie decomposition analysis revealed that 72.06% of the male-female disparity in depression could be explained by observable factors and 27.94% by gender. Conclusions The prevalence of depression in rural elderly men was lower than that in elderly women. Lifestyle, physical health and pain are the main factors causing gender differences in depressive symptoms in rural elderly people.
Study on depression and its influencing factors among late pregnancy women
TIAN Yan-yan, HU Jin-Ping, LIU Xiu-ying, TA Ming-hua, ZHANG Yan-ting, NIU Jian-mei, SHANG Yu-xiu
2018, 22(11): 1152-1155. doi: 10.16462/j.cnki.zhjbkz.2018.11.014
Abstract(447) PDF(56)
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Objective To investigate the current status of depression among late pregnancy women and analyse its influencing factors. Methods Zung self-rating depression scale (SDS) was used to evaluate the depressive status in 1 202 late pregnant women from 6 hospitals in Ningxia. Multivariate Logistic regression model was used to explore the risk factors of depression. Results The prevalence rate of depression in 1 202 late pregnancy women was 51.41%. The scale of SDS was (52.01±10.18) points and higher than the normal score(41.88±10.57), the difference was significant (t=5.806, P<0.001). Multivariate logistic regression analysis showed that abortion, unfortunate marriage, early divorce of parents, low level of education, poor relationship between husband and wife, pregnancy complications and low social support were the risk factors of depressive symptoms in late pregnant women. Conclusion The prevalence rate of depression in late pregnant women was higher. Depression was associated with many factors.
Analysis on the correlation between internet dependence and mental health of medical college students
SHI Wei, DING Shu-shu, DING Lei, LIANG Ya-li, ZUO Ya-ting, YUAN Hui
2018, 22(11): 1156-1159. doi: 10.16462/j.cnki.zhjbkz.2018.11.015
Abstract(468) PDF(29)
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Objective To analyze the correlation between the degree of internet dependence and the state of mental health of medical college students. Methods The internet dependence of college students was investigated by internet addiction scale, and the mental health of college students was investigated by symptom checklist 90 (SCL-90). The differences between different groups of college students' internet dependence and mental health state were analyzed. And the relationship between internet dependence and mental health was studied. Results The internet addiction rate of college students reached 16.72%. There were differences in the degree of internet dependence among different genders, and the differences of abstinence among the factors were statistically significant (χ2=4.487,P=0.034). There were significant differences in tolerance, abstinence and time management among the internet dependence factors of different grades (all P<0.05). There were significant differences in mental health status among different genders and grades of college students (all P<0.05).There was a positive multiple linear regression relationship between compulsive, salience and interpersonal health academic of internet dependence factors and SCL-90 score (all P<0.05). Conclusions There is a correlation between internet dependence and mental health, and internet addiction may aggravate the mental health of college students.
A study on children's intelligence difference with different iodine concentration in drinking water and its influencing factors in Tianjin
CUI Yu-shan, YU Jing-wen, ZHAO Liang, NIE Jun-yan, ZHAO Yang, ZHANG Bin, HOU Chang-chun, LIU Hong-liang
2018, 22(11): 1160-1163. doi: 10.16462/j.cnki.zhjbkz.2018.11.016
Abstract(662) PDF(30)
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Objective To explore the effect of high iodine and other factors on children's intelligence. Methods A total of 399 children aged 7-12 years were randomly selected from the iodine-excess endemial area (water iodine>300 μg/L), iodine-excess area (150-300 μg/L) and non iodine-excess area (water iodine ≤ 100 μg/L). Questionnaire survey was used to collect the general situation of the population and the potential influencing factors of intelligence. Urine samples were tested for urinary iodine and urinary fluoride, and the combined Raven's test for rural China (CRT-RC) was used for intelligence test. Results The level of intelligence quotient (IQ) of 10-12 years old children in the iodine-excess endemial area(107.55±13.81) was significantly lower than that in the iodine-excess area (113.14±10.97) (P=0.019), and the distribulation of IQ was different from that in the control area(P=0.012).The ability of perceived distinguish ability, similarity ability, comparative reasoning ability, series relationship ability and abstract reasoning ability of children aged 10-12 years in the iodine-excess endemial area were lower than those of iodine-excess and non iodine-excess area(all P<0.05). Multivariate Logistic analysis showed that age was a risk factor for intellectual impairment(OR=1.590, 95% CI:1.273-1.986, P<0.001). Conclusion The intelligence level of children aged 10-12 in Tianjin in iodine-excess endemial area decreased. The relationship between iodine and children's intelligence was not found, and further study was needed.
Pollution characteristics and health risk assessment of heavy metals in fine particles with different levels of air pollution in Tianjin
FENG Li-hong, ZHAO Yan, LI Jian-ping, YANG Guang, HAN Peng-hao, WANG Yu-wen, YU Hao, HOU Chang-chun, ZENG Qiang
2018, 22(11): 1164-1167,1172. doi: 10.16462/j.cnki.zhjbkz.2018.11.017
Abstract(363) PDF(30)
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Objective To explore the pollution levels and health effects of heavy metals in fine particulate matter under the weather conditions (air quality index,AQI> 200) of Tianjin in 2016. Methods Regular sampling of the atmosphere of the winter heating season was conducted in Heping District and Beichen District of Tianjin. A total of 159 samples were collected. Sb, As, Cd, Cr, Hg, Pb, Mn, Ni and Se were identified using a 7 500cx inductively coupled plasma mass spectrometer. Health risk of respiratory exposure to carcinogenic and non-carcinogenic heavy metal was assessed through the United States Environmental Protection Agency health risk assessment model. Results The amount of 41 samples was obtained in 21 days of AQI>200, and 118 samples in 59 days of AQI<200. The average value of the average mass concentration of 0.588 mg/m3 in December, which was 7.8 times of the national secondary standard concentration limited. The sequence of the concentrations of the nine heavy metals in the two weather lined from high to low was the constant ones:Pb, Mn, As, Sb, Se, Cd, Cr, Ni, Hg. When the AQI> 200, the excess carcinogenic risk of As for adults were 8.62×10-6 and 9.10×10-6 in urban and suburban respectively. The range of carcinogenic excess risk for children in urban areas and suburbs was from 3.40×10-8 to 4.09×10-6, The non-carcinogenic risk to adults ranged from 9.17×10-4 to 6.56×10-2, and the non-carcinogenic risk to children ranged from 1.49×10-4 to 8.85×10-2, both less than 1. Conclusion As has the highest health risk when AQI> 200. Relevant departments in the development of risk management policies should pay greater attention.
Analysis on the self-rated health of urban new immigrants and its influencing factors
XUE Li, MA Tian-pei, ZHANG Wen-jie, LI Ning-xiu
2018, 22(11): 1168-1172. doi: 10.16462/j.cnki.zhjbkz.2018.11.018
Abstract(460) PDF(22)
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Objective To understand the health status of self-rated health of urban new immigrants and its influencing factors, so as to provide evidence for enhancing the health status of urban new immigrants. Methods The chi-square test was used to compare the differences in demographic characteristics, lifestyles and health status among urban new immigrants in different self-rated health status. The ordinal Logistic regression was used to determine the influencing factors of urban new immigrant self-assessment health. Results A total of 3 247(71.8%) of urban new immigrants evaluated their health status as good, 1 092(24.2%) as general and 181(4.0%) as poor. Multi-factor analysis showed that urban new immigrants aged 18-, 30-, and 60-years old had better self-rated health than those aged 70 years and older; comparing with urban new immigrants with the academics, those with junior high school, high school and above had better self-rated health; urban new immigrants with no work or retirees had self-worse self-rated health; urban new immigrants who had no two weeks of illness, no chronic disease, no one-year hospitalization and no depression had better self-rated health; those who did not drink alcohol and drink occasionally had worse self-rated than those who drunk regularly; those who slept less than 6 hours had worse self-rated health than those who slept 9 hours and over. Conclusion More attention should be paid to the urban new immigrants who are the elderly, unemployed or retired, with high cultural level to promote the health of the urban new immigrants.
Analysis on the self-rated health status and influencing factors of Bengbu residents
ZHU Le-le, ZHU Gao-pei, MENG Ma-cheng, WU Xue-sen
2018, 22(11): 1173-1176,1200. doi: 10.16462/j.cnki.zhjbkz.2018.11.019
Abstract(496) PDF(34)
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Objective To explore the self-rated health status of Bengbu residents and their influencing factors, and provide basis for improving the health level of Bengbu residents. Methods The stratified random sampling method was used to extract the residents who are not less than 18 years old at Bengbu, which conduct the survey with self-designed questionnaire, the data were analysed by multinomial Logistic regression factors of impacting on the health of the residents of self-rated health. Results Among the 3 294 residents, 1 536 (46.6%) individuals evaluated their health status as good, 1 333 (40.5%) as general, and 425 (12.9%) as poor. Multifactor analysis showed that the factors associated with self-reported health have gender, education, income, family history of chronic conditions, suffering from chronic conditions, reporting illness within 2 week, health care costs accounted for earning ratio, alcohol consumption, physical exercise, mental health status (all P<0.05). Conclusions Focus on the health of key groups, such as male, poor education, low income group, etc. Through health education, psychological intervention, residents can improve their self-evaluation of health.
The effects of arsenic exposure on the expression of Nrf2 inhibition cells Keap1 and N6AMT
TU Kai-rong, ZHAO Yu-xin, MENG Hao-xiao, MA Yao, BAI Xue, WU Jun
2018, 22(11): 1177-1180. doi: 10.16462/j.cnki.zhjbkz.2018.11.020
Abstract(312) PDF(22)
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Objective To explore the effects of mixed arsenic exposure on the expression of the Kelch-like epichlorohydrin-related protein 1 (Keap1) and N-6-adenine DNA methyltransferase 1 (N6AMT1) in the cytokines cells (HaCaT cells) inhibited by the nuclear transcription factor red cell-2p45(NF-E2) correlation factor-2(Nrf2). Methods Cells were cultured for 72 hours and divided into four groups:blank control group, Keap-1 inhibitory control group, Nrf-2 inhibitory control group and three Nrf-2 inhibitory mixed arsenic groups. The concentrations of mixed arsenic were 2.1 μmol/L, 4.2 μmol/L and 21.0 μmol/L, respectively. The mRNA and protein levels of N6AMT1 and Keap1 were measured by real-time fluorescence quantitative PCR and western blot. Results Compared with Nrf2 control group, Keap1 and N6AMT1 mRNA expression was not all equal (all P<0.05). Compared with Nrf2 inhibitory control group, the expression of Keap1 protein in low, medium and high doses was increased (all P<0.05), while the expression of N6AMT1 protein was increased in low doses (t=-3.18,P=0.034), and inhibited in medium and high doses (all P<0.05). Conclusions Nrf2 inhibitory condition, the N6AMT1 gene may be related to the regulation of Keap1-Nrf2 pathway. Low dose arsenic exposure, keap1 activation can promote N6AMT1 gene expression and promote arsenic metabolism. High dose arsenic exposure, the down-regulation of N6AMT1 protein expression, inhibit the metabolism of arsenic. The Keap1-Nrf2 pathway may be involved in the regulation of N6AMT1 expression and affect arsenic toxicity.
Rehabilitation effect of hand training on language function of patients with aphasia
YANG Xin-yu, ZHANG Juan-juan, DAI Chen-yang, LI Ying, CAO Shan-shan, WANG Kai
2018, 22(11): 1181-1184. doi: 10.16462/j.cnki.zhjbkz.2018.11.021
Abstract(315) PDF(23)
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Objective To investigate rehabilitation effect of hand training on language function of patients with aphasia. Methods A total of 40 patients with aphasia were randomly divided into control group (n=20) and experimental group (n=20). Both groups received routine drug treatment and rehabilitation, and the experimental group was given additional hand training for 6 weeks. Aphasia battery of Chinese (ABC) was used to evaluate the patients' language function before and after 6 weeks of training respectively. Results The ABC scores of the two groups were significantly improved after 6 weeks (tcon=-10.184, P<0.001;texp=-13.158, P<0.001). There was no statistically significant difference between the two groups before hand training (t=-0.725, P=0.473). After 6 weeks of hand training, the ABC score of the experimental group was significantly higher than that of the control group (t=4.425, P<0.001). There was no significant difference in the ABC scores between the two groups of sensory aphasia (t=-0.171, P=0.872). The ABC scores of patients with motor and mixed aphasia in experimental group were significantly higher than those in the control group (t=5.187, P<0.001; t=4.108, P=0.003). Conclusion Hand training can effectively improve the language function of patients with aphasia.
Drug-resistance and epidemiological characteristics of avian influenza A(H7N9) virus infections in Suzhou City from 2013 to 2017
DONG Ze-feng, XIA Yu, WANG Di, SHEN Qiang, YA Xue-rong
2018, 22(11): 1185-1188. doi: 10.16462/j.cnki.zhjbkz.2018.11.022
Abstract(328) PDF(20)
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Analysis on Clonorchis sinensis infection and related factors among residents in Zhongshan,China
WANG Man, LUO Le, LI Lei, FANG Yue-yi
2018, 22(11): 1189-1191. doi: 10.16462/j.cnki.zhjbkz.2018.11.023
Abstract(502) PDF(25)
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Analysis of current situation and influencing factors of basic public health service in patients with hypertension and type 2 diabetes mellitus in Gansu
WANG Lei-xia, CHEN Yi-jun, LI Jie, CAO Wen-pei, YAN Chun-sheng
2018, 22(11): 1192-1194. doi: 10.16462/j.cnki.zhjbkz.2018.11.024
Abstract(411) PDF(27)
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Survey on the healthy lifestyle of residents in Gangzha District, Nantong
LU Jun-hua, LIN Ling
2018, 22(11): 1195-1197. doi: 10.16462/j.cnki.zhjbkz.2018.11.025
Abstract(231) PDF(18)
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Relationship between physical activity social support and depression symptoms in community elderly
WANG Hong-yu, WEI Wei
2018, 22(11): 1198-1200. doi: 10.16462/j.cnki.zhjbkz.2018.11.026
Abstract(547) PDF(24)
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2018, 22(11): 1201-1201.
Abstract(387) PDF(9)
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