Analysis of neutralizing activity of antibody in serum and its influencing factors in natural population in high incidence areas of severe fever with thrombocytopenia syndrome in Anhui Province

GONG Lei; CHEN Qingqing; WANG Jinsheng; XU Pengpeng; CHENG Donglin; LIU Xuxiang; YANG Kun; SUN Yong; CHU Na; WU Jiabing

doi:10.16462/j.cnki.zhjbkz.2025.02.014

Volume 29 Issue 2

Feb. 2025

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2025 > 29(2): 211-216

GONG Lei, CHEN Qingqing, WANG Jinsheng, XU Pengpeng, CHENG Donglin, LIU Xuxiang, YANG Kun, SUN Yong, CHU Na, WU Jiabing. Analysis of neutralizing activity of antibody in serum and its influencing factors in natural population in high incidence areas of severe fever with thrombocytopenia syndrome in Anhui Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(2): 211-216. doi: 10.16462/j.cnki.zhjbkz.2025.02.014

Citation:

GONG Lei, CHEN Qingqing, WANG Jinsheng, XU Pengpeng, CHENG Donglin, LIU Xuxiang, YANG Kun, SUN Yong, CHU Na, WU Jiabing. Analysis of neutralizing activity of antibody in serum and its influencing factors in natural population in high incidence areas of severe fever with thrombocytopenia syndrome in Anhui Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(2): 211-216. doi: 10.16462/j.cnki.zhjbkz.2025.02.014

Citation:

GONG Lei, CHEN Qingqing, WANG Jinsheng, XU Pengpeng, CHENG Donglin, LIU Xuxiang, YANG Kun, SUN Yong, CHU Na, WU Jiabing. Analysis of neutralizing activity of antibody in serum and its influencing factors in natural population in high incidence areas of severe fever with thrombocytopenia syndrome in Anhui Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(2): 211-216. doi: 10.16462/j.cnki.zhjbkz.2025.02.014

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Analysis of neutralizing activity of antibody in serum and its influencing factors in natural population in high incidence areas of severe fever with thrombocytopenia syndrome in Anhui Province

doi: 10.16462/j.cnki.zhjbkz.2025.02.014

1.
Anhui Provincial Center for Disease Control and Prevention, Hefei 230601, China
2.
Anqing Municipal Center for Disease Control and Prevention, Anqing 246005, China
3.
Lu′an Municipal Center for Disease Control and Prevention, Lu′an 237010, China
4.
Chuzhou Municipal Center for Disease Control and Prevention, Chuzhou 239099, China
5.
Hefei Municipal Center for Disease Control and Prevention, Hefei 230022, China
6.
Maanshan Municipal Center for Disease Control and Prevention, Maanshan 243011, China

Funds:

Collaborative Education Innovation Project of School of Public Health, Anhui Medical University 2024GWXTYRZ002

More Information

Corresponding author: WU Jiabing, E-mail: wjb0386@163.com
Received Date: 2024-02-23
Rev Recd Date: 2024-11-20

Available Online: 2025-03-08

Publish Date: 2025-02-10

Abstract

Abstract

Objective The purpose of this study was to understand the level of IgG in serum of natural people in areas with high incidence of severe fever with thrombocytopenia syndrome (SFTS) in Anhui Province and its influencing factors, so as to provide basis for the prevention and control of SFTS. Methods The serum samples and epidemiological data of natural population in areas with high incidence of SFTS were collected in the year of 2021 and divided into immunoglobulin G (IgG) negative group and positive group according to the results of IgG antibody test, and compare the demographic characteristics, past health status, environmental and medium exposure between the two groups. χ² or Z test were used for univariate analysis, and logistic regression model was used for multivariate analysis. Results A total of 1 255 cases were included in this study, of which 174 cases (13.86%) were IgG antibody positive. The univariate analysis showed that there was a significant difference in the demographic characteristics of the two groups in terms of village type and age (all P < 0.05). There was a significant difference in the past health status of the two groups in terms of whether SFTS was diagnosed or not (χ² =13.678, P < 0.05). There was a significant difference in the environmental exposure of the two groups in terms of engaging in agricultural production, being bitten by ticks, living with weed and ticks around residential areas, and working in the field (P < 0.05). There was a significant difference in the medium exposure of the two groups in terms of sitting and lying near the rat hole (χ² =8.576, P < 0.05). The binary logistic regression analysis showed that the monitoring villages (OR=2.093, 95% CI: 1.489-2.941), high age (OR=1.028, 95% CI: 1.013-1.043), had been diagnosed with SFTS (OR=3.089, 95% CI: 1.021-9.346), engaged in agricultural production (OR=1.728, 95% CI: 1.090-2.741), and had been bitten by ticks (OR=1.990, 95% CI: 1.366-2.898) were the risk factors for IgG antibody positive (all P < 0.05). Conclusions This study finds that the IgG antibody positive rate is higher in natural populations in areas with high incidence of SFTS in Anhui province. Therefore, it is necessary to strengthen health interventions for populations in these areas to reduce the risk of infection.
- Severe fever with thrombocytopenia syndrome,
- Antibody,
- Emerging infectious disease

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References(20)

References

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