Health behavior models and relevant influencing factors related to medication adherence

LU Qiaoshan; MA Xiaohong; YE Junjie; ZHAO Lin; HU Xinxuan; CHEN Qiulan; QIN Huijie; TANG Xianyan

doi:10.16462/j.cnki.zhjbkz.2025.02.016

Volume 29 Issue 2

Feb. 2025

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2025 > 29(2): 224-230

LU Qiaoshan, MA Xiaohong, YE Junjie, ZHAO Lin, HU Xinxuan, CHEN Qiulan, QIN Huijie, TANG Xianyan. Health behavior models and relevant influencing factors related to medication adherence[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(2): 224-230. doi: 10.16462/j.cnki.zhjbkz.2025.02.016

Citation:

LU Qiaoshan, MA Xiaohong, YE Junjie, ZHAO Lin, HU Xinxuan, CHEN Qiulan, QIN Huijie, TANG Xianyan. Health behavior models and relevant influencing factors related to medication adherence[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(2): 224-230. doi: 10.16462/j.cnki.zhjbkz.2025.02.016

Citation:

LU Qiaoshan, MA Xiaohong, YE Junjie, ZHAO Lin, HU Xinxuan, CHEN Qiulan, QIN Huijie, TANG Xianyan. Health behavior models and relevant influencing factors related to medication adherence[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(2): 224-230. doi: 10.16462/j.cnki.zhjbkz.2025.02.016

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Health behavior models and relevant influencing factors related to medication adherence

doi: 10.16462/j.cnki.zhjbkz.2025.02.016

1.
Department of Epidemiology and Biostatistics, School of Public Health, Guangxi Medical University, Nanning 530021, China
2.
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center For Disease Control And Prevention, Beijing 102200, China

Funds:

National Natural Science Foundation of China 81960615

National Natural Science Foundation of China 82160646

National Natural Science Foundation of China 82360666

China Medical Board 14-202

China Medical Board 19-307

More Information

Corresponding author: TANG Xianyan, E-mail: tangxianyan0746@163.com
Received Date: 2024-08-27
Rev Recd Date: 2024-11-15

Available Online: 2025-03-08

Publish Date: 2025-02-10

Abstract

Abstract

Adherence is defined as the extent to which a patient′s or individual′s behavior aligns with the professional recommendation of the healthcare provider regarding medication, dietary modifications, and lifestyle alterations. Adherence is important to a patient′s or individual′s health status and treatment outcome. We summarized health behavior models of medication adherence and underlying principles. Furthermore, we systematically reviewed the relevant influencing factors regarding socio-economic status, the healthcare system, diseases, treatments, and patient characteristics that would affect patients′ medication adherence, based on the five dimensions of adherence proposed by the World Health Organization. Findings in this study would provide scientific evidence to improve patients′ medication adherence and prognosis outcomes.

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References(38)

References

[1]	Geest DS, Sabaté E. Adherence to long-term therapies: evidence for action[J]. Eur J Cardiovasc Nurs, 2003, 2(4): 323-323. DOI: 10.1016/s1474-5151(03)00091-4.
[2]	Amico KR, Mugavero M, Krousel-Wood MA, et al. Advantages to using social-behavioral models of medication adherence in research and practice[J]. J Gen Intern Med, 2018, 33(2): 207-215. DOI: 10.1007/s11606-017-4197-5.
[3]	Lin CY, Updegraff JA, Pakpour AH. The relationship between the theory of planned behavior and medication adherence in patients with epilepsy[J]. Epilepsy Behav, 2016, 61: 231-236. DOI: 10.1016/j.yebeh.2016.05.030.
[4]	Beisel C, Poretta T, Sheppard VB, et al. Adherence to adjuvant therapy in patients with resected melanoma: an application of the theory of planned behavior[J]. Adv Ther, 2022, 39(9): 4061-4075. DOI: 10.1007/s12325-022-02221-2.
[5]	Kopelowicz A, Zarate R, Wallace CJ, et al. Using the theory of planned behavior to improve treatment adherence in Mexican Americans with schizophrenia[J]. J Consult Clin Psychol, 2015, 83(5): 985-993. DOI: 10.1037/a0039346.
[6]	Yang C, Hui ZZ, Zeng DJ, et al. Examining and adapting the information-motivation-behavioural skills model of medication adherence among community-dwelling older patients with multimorbidity: protocol for a cross-sectional study[J]. BMJ Open, 2020, 10(3): e033431. DOI: 10.1136/bmjopen-2019-033431.
[7]	Yang C, Lee DTF, Chair SY. Validation and adaption of an Information-Motivation-Behavioral Skills model of medication adherence in older patients with multimorbidity[J]. Patient Educ Couns, 2023, 113: 107756. DOI: 10.1016/j.pec.2023.107756.
[8]	张卉, 张腾, 李新, 等. 基于IMB技巧模型的COPD患者肺康复依从性影响因素的结构方程模型分析[J]. 护理实践与研究, 2022, 19(18): 2732-2735. DOI: 10.3969/j.issn.1672-9676.2022.18.011. Zhang H, Zhang T, Li X, et al. Structural equation of influencing factors of pulmonary rehabilitation adherence in patients with COPD based on information-motivation-behavioral skill model[J]. Nursing Practice and Research, 2022, 19(18): 2732-2735. DOI: 10.3969/j.issn.1672-9676.2022.18.011.
[9]	Lin MX, Chen TT, Fan GH. Current status and influential factors associated with adherence to self-monitoring of blood glucose with type 2 diabetes mellitus patients in grassroots communities: a cross-sectional survey based on information-motivation-behavior skills model in China[J]. Front Endocrinol, 2023, 14: 1111565. DOI: 10.3389/fendo.2023.1111565.
[10]	Du L, Chen X, Zhu XX, et al. Determinants of medication adherence for pulmonary tuberculosis patients during continuation phase in Dalian, NorthEast China[J]. Patient Prefer Adherence, 2020, 14: 1119-1128. DOI: 10.2147/PPA.S243734.eCollection2020.
[11]	Jones CJ, Smith H, Llewellyn C. Evaluating the effectiveness of health belief model interventions in improving adherence: a systematic review[J]. Health Psychol Rev, 2014, 8(3): 253-269. DOI: 10.1080/17437199.2013.802623.
[12]	傅华, 施榕, 张竞超, 等. 健康教育学[M]. 北京: 人民卫生出版社, 2017: 21-133. Fu H, Shi R, Zhang JC, et al. Science of health education[M]. Beijing: People's Medical Publishing House, 2017: 21-133.
[13]	Tareke KG, Tesfaye G, Koricha ZB. Development and validation of Health Belief Model based instrument to assess secondary school student's adherence to COVID-19 self-protective practices in Jimma, Oromia, Ethiopia[J]. PLoS One, 2022, 17(12): e0279440. DOI: 10.1371/journal.pone.0279440.
[14]	Clark NM, Becker MH. Theoretical models and strategies for improving adherence and disease management[M]. The handbook of health behavior change, 2nd ed. New York, NY, US: Springer Publishing Company, 1998: 5-32.
[15]	Rogers RW. A protection motivation theory of fear appeals and attitude change1[J]. J Psychol, 1975, 91(1): 93-114. DOI: 10.1080/00223980.1975.9915803.
[16]	Lahiri A, Jha SS, Chakraborty A, et al. Role of threat and coping appraisal in protection motivation for adoption of preventive behavior during COVID-19 pandemic[J]. Front Public Health, 2021, 9: 678566. DOI: 10.3389/fpubh.2021.678566.
[17]	Lee SY, Yang SS, Lwin MO. Are threat perceptions associated with patient adherence to antibiotics? Insights from a survey regarding antibiotics and antimicrobial resistance among the Singapore public[J]. BMC Public Health, 2023, 23(1): 532. DOI: 10.1186/s12889-023-15184-y.
[18]	Şanlitürk D, Ayaz-Alkaya S. The effect of a theory of planned behavior education program on asthma control and medication adherence: a randomized controlled trial[J]. J Allergy Clin Immunol Pract, 2021, 9(9): 3371-3379. DOI: 10.1016/j.jaip.2021.03.060.
[19]	谢传桃, 顾艳荭, 李玉梅, 等. 基于COM-B模型的老年慢性心力衰竭病人服药依从性影响因素[J]. 护理研究, 2024, 38(2): 246-251 DOI: 10.12102/j.issn.1009-6493.2024.02.009. Xie CT, Gu YH, Li YM, et al. Influencing factors of medication adherence among older patients with chronic heart failure: an analysis based on COM-B model[J]. Chinese Nursing Research, 2024, 38(2): 246-251. DOI: 10.12102/j.issn.1009-6493.2024.02.009.
[20]	Bandura A. Health promotion by social cognitive means[J]. Health Educ Behav, 2004, 31(2): 143-164. DOI: 10.1177/1090198104263660.
[21]	Farhangian ME, Huang WW, Feldman SR. Adherence to oral and topical medications in cutaneous lupus erythematosus is not well characterized[J]. Dermatol Ther, 2015, 5(2): 91-105. DOI: 10.1007/s13555-015-0075-4.
[22]	Boukhechba M, Baee S, Nobles AL, et al. A social cognitive theory-based framework for monitoring medication adherence applied to endocrine therapy in breast cancer survivors[J]. IEEE EMBS Int Conf Biomed Health Inform, 2018, 2018: 275-278. DOI: 10.1109/BHI.2018.8333422.
[23]	McAuley E, Mullen SP, Szabo AN, et al. Self-regulatory processes and exercise adherence in older adults: executive function and self-efficacy effects[J]. Am J Prev Med, 2011, 41(3): 284-290. DOI: 10.1016/j.amepre.2011.04.014.
[24]	Ewulu AR, Singh R, Roberson KB, et al. Toward a better understanding of treatment adherence: incorporating accountability explicitly into the social cognitive theory of adherence behavior[J]. J Dermatolog Treat, 2024, 35(1): 2351493. DOI: 10.1080/09546634.2024.2351493.
[25]	Berben L, Dobbels F, Engberg S, et al. An ecological perspective on medication adherence[J]. West J Nurs Res, 2012, 34(5): 635-653. DOI: 10.1177/0193945911434518.
[26]	Oori MJ, Mohammadi F, Norouzi K, et al. Conceptual model of medication adherence in older adults with high blood pressure-an integrative review of the literature[J]. Curr Hypertens Rev, 2019, 15(2): 85-92. DOI: 10.2174/1573402114666181022152313.
[27]	Gabster A, Socha E, Pascale JM, et al. Barriers and facilitators to antiretroviral adherence and retention in HIV care among people living with HIV in the Comarca Ngäbe-Buglé, Panama[J]. PLoS One, 2022, 17(6): e0270044. DOI: 10.1371/journal.pone.0270044.
[28]	Saran R, Bragg-Gresham JL, Rayner HC, et al. Nonadherence in hemodialysis: associations with mortality, hospitalization, and practice patterns in the DOPPS[J]. Kidney Int, 2003, 64(1): 254-262. DOI: 10.1046/j.1523-1755.2003.00064.x.
[29]	Liu FY, Chang HJ, Liu XJ. Adherence behaviors and related factors among elderly hypertensive patients in China: evidence from the china health and retirement longitudinal study[J]. Patient Prefer Adherence, 2023, 17: 3539-3553. DOI: 10.2147/PPA.S445789.
[30]	Damschroder LJ, Reardon CM, Opra Widerquist MA, et al. Conceptualizing outcomes for use with the consolidated framework for implementation research (CFIR): the CFIR outcomes addendum[J]. Implement Sci, 2022, 17(1): 7. DOI: 10.1186/s13012-021-01181-5.
[31]	Haberer JE, Garrison L, Tumuhairwe JB, et al. Factors affecting the implementation of electronic antiretroviral therapy adherence monitoring and associated interventions for routine hiv care in uganda: qualitative study[J]. J Med Internet Res, 2020, 22(9): e18038. DOI: 10.2196/18038.
[32]	Garrido MA, Alvarez EA, Ponce DP, et al. Consolidated framework for advancing implementation science for the implementation process and adherence assessment of a non-pharmacological delirium prevention program[J]. Int J Geriatr Psychiatry, 2021, 36(2): 302-313. DOI: 10.1002/gps.5425.
[33]	Habte BM, Kebede T, Fenta TG, et al. Barriers and facilitators to adherence to anti-diabetic medications: Ethiopian patients' perspectives[J]. Afr J Prim Health Care Fam Med, 2017, 9(1): e1-e9. DOI: 10.4102/phcfm.v9i1.1411.
[34]	Zolnierek KB, Dimatteo MR. Physician communication and patient adherence to treatment: a Meta-analysis[J]. Med Care, 2009, 47(8): 826-834. DOI: 10.1097/MLR.0b013e31819a5acc.
[35]	Sloan M, Lever E, Gordon C, et al. Medication decision-making and adherence in lupus: patient-physician discordance and the impact of previous 'adverse medical experiences'[J]. Rheumatology, 2022, 61(4): 1417-1429. DOI: 10.1093/rheumatology/keab534.
[36]	Li HY, Jia XN, Min H, et al. Relationships between beliefs about statins and non-adherence in inpatients from Northwestern China: a cross-sectional survey[J]. Front Pharmacol, 2023, 14: 1078215. DOI: 10.3389/fphar.2023.1078215.
[37]	Easthall C, Taylor N, Bhattacharya D. Barriers to medication adherence in patients prescribed medicines for the prevention of cardiovascular disease: a conceptual framework[J]. Int J Pharm Pract, 2019, 27(3): 223-231. DOI: 10.1111/ijpp.12491.
[38]	Sweileh WM, Zyoud SH, Abu Nab'a RJ, et al. Influence of patients' disease knowledge and beliefs about medicines on medication adherence: findings from a cross-sectional survey among patients with type 2 diabetes mellitus in Palestine[J]. BMC Public Health, 2014, 14: 94. DOI: 10.1186/1471-2458-14-94.