Study on the association between serum uric acid to creatinine ratio and metabolic syndrome and its components among aged 35-74 years Zhuang minority residents in Guangxi

WEI Yuxia; QIU Xiaoqiang; ZENG Xiaoyun; SU Li; HUANG Dongping; LIU Shun; XIE Yihong

doi:10.16462/j.cnki.zhjbkz.2025.04.007

Volume 29 Issue 4

Apr. 2025

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2025 > 29(4): 413-420

WEI Yuxia, QIU Xiaoqiang, ZENG Xiaoyun, SU Li, HUANG Dongping, LIU Shun, XIE Yihong. Study on the association between serum uric acid to creatinine ratio and metabolic syndrome and its components among aged 35-74 years Zhuang minority residents in Guangxi[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(4): 413-420. doi: 10.16462/j.cnki.zhjbkz.2025.04.007

Citation:

WEI Yuxia, QIU Xiaoqiang, ZENG Xiaoyun, SU Li, HUANG Dongping, LIU Shun, XIE Yihong. Study on the association between serum uric acid to creatinine ratio and metabolic syndrome and its components among aged 35-74 years Zhuang minority residents in Guangxi[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(4): 413-420. doi: 10.16462/j.cnki.zhjbkz.2025.04.007

Citation:

WEI Yuxia, QIU Xiaoqiang, ZENG Xiaoyun, SU Li, HUANG Dongping, LIU Shun, XIE Yihong. Study on the association between serum uric acid to creatinine ratio and metabolic syndrome and its components among aged 35-74 years Zhuang minority residents in Guangxi[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2025, 29(4): 413-420. doi: 10.16462/j.cnki.zhjbkz.2025.04.007

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Study on the association between serum uric acid to creatinine ratio and metabolic syndrome and its components among aged 35-74 years Zhuang minority residents in Guangxi

doi: 10.16462/j.cnki.zhjbkz.2025.04.007

1.
Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China
2.
Department of Health Chemistry, School of Public Health, Guangxi Medical University, Nanning 530021, China
3.
Department of Maternal & Child and Adolescent Health, School of Public Health, Guangxi Medical University, Nanning 530021, China

Funds:

National Key Research and Development Program of China 2017YFC0907103

National Natural Science Foundation of China 81960619

Natural Science Foundation of Guangxi 2022GXNSFAA035623

More Information

Corresponding author: XIE Yihong, E-mail: gxxieyihong@163.com
Received Date: 2024-09-26
Rev Recd Date: 2025-01-09
Publish Date: 2025-04-10

Abstract

Abstract

Objective To explore the association between serum uric acid to creatinine ratio (SUA/Cr) and metabolic syndrome (MS) and the number of its components among aged 35-74 years Zhuang residents in Guangxi, providing scientific evidences for the management and intervention of MS. Methods The baseline data of Guangxi ethnic minorities cohort of chronic diseases in 2018-2019 was collected using structure questionnaire, physical examination and biochemical test. Kruskal-Wallis rank sum test, binomial and multinomial logistic regression model were used in data analysis. The dose-response relationship between SUA level, SUA/Cr, and the risk of MS was evaluated using restricted cubic spline. Results A total of 11 134 Zhuang adults were included, with the mean age of 55.3 years, of which 55.3% were females. The prevalence rate of MS was 23.1%, with a significantly higher prevalence rate in females compared to males (25.4% vs 20.2%, P < 0.001). The prevalence rate of MS was 20.2%, 33.0%, 38.0%, and 46.3% in the SUA ≤420, > 420- < 480, 480- < 540、and ≥540 μmol/L groups, respectively. After controlling for potential confounding factors, there was a dose-response relationship between SUA level, SUA/Cr and the risk of MS. The effects of SUA, SUA/Cr on MS components increased with the level of SUA and SUA/Cr increased. In the group with a higher number of MS components, the same SUA or SUA/Cr had a more significant effect (P < 0.001). Conclusions The levels of SUA and SUA/Cr are important influencing factors of MS and its components in Zhuang residents. In the future, health education and management of hyperuricemia, MS and its components should be strengthened to control SUA at an ideal level.
- Serum uric acid level,
- Serum uric acid to creatinine ratio,
- Metabolic syndrome

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References(26)

References

[1]	Martin SS, Aday AW, Almarzooq ZI, et al. 2024 heart disease and stroke statistics: a report of US and global data from the American heart association [J]. Circulation, 2024, 149(8): e347-e913. DOI: 10.1161/CIR.0000000000001209.
[2]	Yao F, Bo YC, Zhao LY, et al. Prevalence and influencing factors of metabolic syndrome among adults in China from 2015 to 2017 [J]. Nutrients, 2021, 13(12): 4475. DOI: 10.3390/nu13124475.
[3]	Qin XZ, Qiu L, Tang GD, et al. Prevalence of metabolic syndrome among ethnic groups in China [J]. BMC Public Health, 2020, 20(1): 297. DOI: 10.1186/s12889-020-8393-6.
[4]	Ahmadi A, Esmaeili F, Hasheminia M, et al. The association between serum uric acid and metabolic syndrome and its components: a decade follow-up in the tehran lipid and glucose study [J]. Nutr Metab Cardiovasc Dis, 2025, 103847. DOI: 10.1016/J.NUMECD.2025.103847.
[5]	Li L, Song QF, Yang X. Lack of associations between elevated serum uric acid and components of metabolic syndrome such as hypertension, dyslipidemia, and T2DM in overweight and obese Chinese adults [J]. J Diabetes Res, 2019, 2019: 3175418. DOI: 10.1155/2019/3175418.
[6]	Kawamoto R, Ninomiya D, Akase T, et al. Serum uric acid to creatinine ratio independently predicts incident metabolic syndrome among community-dwelling persons [J]. Metab Syndr Relat Disord, 2019, 17(2): 81-89. DOI: 10.1089/met.2018.0055.
[7]	Grundy SM, Cleeman JI, Daniels SR, et al. Diagnosis and management of the metabolic syndrome: an American heart association/national heart, lung, and blood institute scientific statement: executive summary [J]. Crit Pathw Cardiol, 2005, 4(4): 198-203. DOI: 10.1097/00132577-200512000-00018.
[8]	中华医学会内分泌学分会. 中国高尿酸血症与痛风诊疗指南(2019) [J]. 中华内分泌代谢杂志, 2020, 36(1): 1-13. DOI: 10.3760/cma.j.issn.1000-6699.2020.01.001. Endocrinology Branch of Chinese Medical Association. Guideline for the diagnosis and management of hyperuricemia and gout in China(2019) [J]. Chin J Endocrinol Metab, 2020, 36(1): 1-13. DOI: 10.3760/cma.j.issn.1000-6699.2020.01.001.
[9]	韦玉霞, 仇小强, 曾小云, 等. 广西35~74岁壮族男性饮酒与尿酸水平的关系研究[J]. 中国慢性病预防与控制, 2024, 32(10): 762-767, 777. DOI: 10.16386/j.cjpccd.issn.1004-6194.2024.10.008. Wei YX, Qiu XQ, Zeng XY, et al. Study on the association between drinking and serum uric acid levels among aged 35-74 years Zhuang minority male residents in Guangxi [J]. Chin J Prev Contr Chron Dis, 2024, 32(10): 762-767, 777. DOI: 10.16386/j.cjpccd.issn.1004-6194.2024.10.008.
[10]	Zhao YL, Yan H, Yang RH, et al. Prevalence and determinants of metabolic syndrome among adults in a rural area of Northwest China [J]. PLoS One, 2014, 9(3): e91578. DOI: 10.1371/journal.pone.0091578.
[11]	闫慧敏, 张梅, 张笑, 等. 中国老年人代谢综合征流行特征及其影响因素研究[J]. 中华流行病学杂志, 2019, 40(3): 284-289. DOI: 10.3760/cma.j.issn.0254-6450.2019.03.006. Yan HM, Zhang M, Zhang X, et al. Study of epidemiological characteristics of metabolic syndrome and influencing factors in elderly people in China [J]. Chin J Epidemiol, 2019, 40(3): 284-289. DOI: 10.3760/cma.j.issn.0254-6450.2019.03.006.
[12]	Yao SL, Zhou Y, Xu L, et al. Association between hyperuricemia and metabolic syndrome: a cross-sectional study in Tibetan adults on the Tibetan Plateau [J]. Front Endocrinol, 2022, 13: 964872. DOI: 10.3389/fendo.2022.964872.
[13]	Kim ES, Kwon HS, Ahn CW, et al. Serum uric acid level is associated with metabolic syndrome and microalbuminuria in Korean patients with type 2 diabetes mellitus [J]. J Diabetes Complications, 2011, 25(5): 309-313. DOI: 10.1016/j.jdiacomp.2010.09.004.
[14]	Cao TR, Tong C, Halengbieke A, et al. Serum uric acid to creatinine ratio and metabolic syndrome in middle-aged and elderly population: Based on the 2015 CHARLS [J]. Nutr Metab Cardiovasc Dis, 2023, 33(7): 1339-1348. DOI: 10.1016/j.numecd.2023.05.004.
[15]	Saito Y, Kitahara H, Nakayama T, et al. Relation of elevated serum uric acid level to endothelial dysfunction in patients with acute coronary syndrome [J]. J Atheroscler Thromb, 2019, 26(4): 362-367. DOI: 10.5551/jat.45179.
[16]	Choi Y, Yang H, Jeon S, et al. Prediction of insulin resistance and elevated liver transaminases using serum uric acid and derived markers in children and adolescents [J]. Eur J Clin Nutr, 2024, 78(10): 864-871. DOI: 10.1038/s41430-024-01475-z.
[17]	Ndrepepa G. Uric acid and cardiovascular disease [J]. Clin Chim Acta, 2018, 484: 150-163. DOI: 10.1016/j.cca.2018.05.046.
[18]	Shahid R, Hussain M, Ghori MU, et al. Association of hyperuricemia with metabolic syndrome and its components in an adult population of Faisalabad, Pakistan [J]. Nutr Metab Cardiovasc Dis, 2024, 34(6): 1554-1558. DOI: 10.1016/j.numecd.2024.03.017.
[19]	Al-Daghri NM, Al-Attas OS, Wani K, et al. Serum uric acid to creatinine ratio and risk of metabolic syndrome in Saudi type 2 diabetic patients [J]. Sci Rep, 2017, 7(1): 12104. DOI: 10.1038/s41598-017-12085-0.
[20]	Tao J, Shen X, Li J, et al. Serum uric acid to creatinine ratio and metabolic syndrome in postmenopausal Chinese women [J]. Medicine, 2020, 99(17): e19959. DOI: 10.1097/MD.0000000000019959.
[21]	Jia ZT, Zhang XQ, Kang S, et al. Serum uric acid levels and incidence of impaired fasting glucose and type 2 diabetes mellitus: a Meta-analysis of cohort studies [J]. Diabetes Res Clin Pract, 2013, 101(1): 88-96. DOI: 10.1016/j.diabres.2013.03.026.
[22]	Martinelli I, Tomassoni D, Moruzzi M, et al. Cardiovascular changes related to metabolic syndrome: evidence in obese zucker rats [J]. Int J Mol Sci, 2020, 21(6): 2035. DOI: 10.3390/ijms21062035.
[23]	Jang KW, Hur J, Lee DW, et al. Metabolic syndrome, kidney-related adiposity, and kidney microcirculation: unraveling the damage [J]. Biomedicines, 2024, 12(12): 2706. DOI: 10.3390/biomedicines12122706.
[24]	Liu N, Xu H, Sun QQ, et al. The role of oxidative stress in hyperuricemia and xanthine oxidoreductase (XOR) inhibitors [J]. Oxid Med Cell Longev, 2021, 2021: 1470380. DOI: 10.1155/2021/1470380.
[25]	Kim GH, Jun JB. Altered serum uric acid levels in kidney disorders [J]. Life, 2022, 12(11): 1891. DOI: 10.3390/life12111891.
[26]	Sun HL, Chang XN, Bian NN, et al. Adipose tissue insulin resistance is positively associated with serum uric acid levels and hyperuricemia in northern Chinese adults [J]. Front Endocrinol, 2022, 13: 835154. DOI: 10.3389/fendo.2022.835154.