Abstract: Objective To assess the effect of malaria control activities in China-Myanmar border areas and provide references for the following related work. Methods Data on the epidemic situation and malaria control activities was collected from 12 counties along China-Myanmar border, Yunnan Province during 2007 to 2013. And then the effect of prevention was evaluated. Results There were 915 270 febrile patients indentified through microscopy examination in twelve counties along China-Myanmar border, Yunnan Province, 13 146 malaria cases were treated, 121 894 cases were cured in the resting phase, and 292 720 received preventive medication. Meanwhile, 1 408 573 were protected by indoor residual spraying and 1 114 360 were protected by insecticide-treated nets. Malaria incidence decreased from 11.35/10 000 in 2007 to 0.88/10 000 in 2013, with a reduction rate of 92.24%. The total number of malaria cases decreased from 6 108 in 2007 to 290 in 2013, with a reduction rate of 95.25%. The total number of indigenous infection cases decreased from 3 546 in 2007 to 32 in 2013, with a reduction rate of 99.10%. The imported malaria cases proportion in total cases increased from 41.95% in 2007 to 88.97% in 2013. And they were mostly came from Myanmar. Conclusions The malaria burden in the China-Myanmar border area was dramatically reduced from 2007 to 2013. However, the surveillance on the transmission risk bought from imported malaria still needs to be reinforced. The mechanism for malaria joint prevention and control should be improved in the China-Myanmar border areas for continuous maintenance of malaria elimination.