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山西省强制戒毒者HBV感染状况及影响因素分析

王君,  李春霞,  潘明虎,  程雁鹏,  苏通,  冯永亮,  王素萍

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文章导航 > 中华疾病控制杂志  > 2016 >  20(9): 876-879,884
王君, 李春霞, 潘明虎, 程雁鹏, 苏通, 冯永亮, 王素萍. 山西省强制戒毒者HBV感染状况及影响因素分析[J]. 中华疾病控制杂志, 2016, 20(9): 876-879,884. doi: 10.16462/j.cnki.zhjbkz.2016.09.004
引用本文: 王君, 李春霞, 潘明虎, 程雁鹏, 苏通, 冯永亮, 王素萍. 山西省强制戒毒者HBV感染状况及影响因素分析[J]. 中华疾病控制杂志, 2016, 20(9): 876-879,884. doi: 10.16462/j.cnki.zhjbkz.2016.09.004
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WANG Jun, LI Chun-xia, PAN Ming-hu, CHENG Yan-peng, SU Tong, FENG Yong-liang, WANG Su-ping. Study on HBV infection and related factors among drug users in compulsory detoxification centers in Shanxi Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(9): 876-879,884. doi: 10.16462/j.cnki.zhjbkz.2016.09.004
Citation: WANG Jun, LI Chun-xia, PAN Ming-hu, CHENG Yan-peng, SU Tong, FENG Yong-liang, WANG Su-ping. Study on HBV infection and related factors among drug users in compulsory detoxification centers in Shanxi Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(9): 876-879,884. doi: 10.16462/j.cnki.zhjbkz.2016.09.004
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山西省强制戒毒者HBV感染状况及影响因素分析

doi: 10.16462/j.cnki.zhjbkz.2016.09.004

  • 山西医科大学公共卫生学院流行病学教研室, 山西 太原 030001

基金项目: 

“十二五”国家科技重大专项（2012ZX10002001-003）；山西省普通高校特色重点学科建设项目（2011年）

详细信息
    作者简介:

    王君(1990-),男,山西长治人,在读硕士研究生。主要研究方向:传染病流行病学。

  • 中图分类号: R512.62;R181

Study on HBV infection and related factors among drug users in compulsory detoxification centers in Shanxi Province

  • Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China

    摘要
  • 摘要: 目的 了解山西省强制戒毒者乙型肝炎病毒（hepatitis B virus，HBV）感染状况，初步探讨强制戒毒者HBV感染的影响因素。方法 于2014年6月～12月对山西省3所强制戒毒所1 176名强制戒毒者进行面对面问卷调查，收集一般人口学特征、HBV感染的可能影响因素等资料；同时采集静脉血5 ml，采用酶联免疫吸附（enzyme linked immunosorbent assay，ELISA）法检测HBsAg和抗-HBs。用非条件Logistic回归模型分析HBV感染的影响因素，并对分析出的危险因素进行交互作用分析。结果 1 176名强制戒毒者年龄范围为18～65岁，年龄均数为（37.91±8.58）岁，其中男性1 118人，女性58人；HBsAg、抗-HBs的阳性率分别为4.68%（55/1 176）、34.69%（408/1 176）。Logistic回归分析显示，乙肝家族史（OR=6.654，95% CI: 2.550～17.364）、修脚史（OR=1.955，95% CI: 1.086～3.518）和丙型肝炎史（OR=7.935，95% CI: 1.496～42.098）是HBV感染的危险因素，血清抗-HBs阳性是HBV感染的保护因素（OR=0.125，95% CI: 0.044～0.359）。修脚史和乙肝家族史之间未发现相加及相乘交互作用（均有P>0.05）。结论 强制戒毒人群是HBV感染的高危人群，乙肝家族史、丙型肝炎史和修脚史是该人群HBV感染的危险因素，对该人群应加强乙肝疫苗接种，并采取针对性的干预措施。
    Abstract: Objective To understand the seroepidemiological status of hepatitis B virus (HBV) and its vaccination coverage, and to preliminarily explore the influencing factors of HBV infection among drug users in Shanxi province, China. Methods 1 176 drug users in three compulsory detoxification centers were included in the study, from June to December 2014.Information on the general demographic characteristics, the related factors of HBV infection and history of hepatitis B vaccination were collected through questionnaires at face-to-face interviews. Anticoagulant venous blood samples of 5 ml were also collected for HBsAg and anti-HBs testing, using the enzyme linked immunosorbent assay (ELISA) method. Unconditional logistic regression model was used to analyze the influencing factors of HBV infection. Results A total number of 1 176 drug users were included in the study, including 1 118 males and 58 females, with a mean age of (37.91±8.58) years. According to the laboratory results, HBsAg positive was defined as the case group (55), and HBsAg negative was defined as the control group (1 121).Age and gender differences between the two groups had no statistically significant differences. The positive rate of HBsAg and anti-HBs were 4.68% (55/1 176)and 34.69 %(408/1 176), respectively. 717 subjects (60.97%) were negative for both markers. The coverage rate of hepatitis B vaccination was low, only 22.62%(266/1 176) of the drug users had a clear history of hepatitis B vaccination. The logistic regression analysis showed that family history of HBV infection (OR=6.654, 95% CI:2.550-17.364), having pedicure(OR=1.955, 95% CI:1.086-3.518) and history of hepatitis C infection(OR=7.935,95% CI:1.496-42.098)were associated with HBsAg positive. Anti-HBs positive was a protective factor of HBsAg positive. Additive interaction and multiplication interaction were not found between pedicure history and family history of HBV infection(all P>0.05). Conclusions Drug users in compulsory detoxification centers were high-risk group of HBV infection, and their prior hepatitis B vaccination coverage rate and anti-HBs positive rate were low. Having family history of HBV infection, pedicure experiences and history of hepatitis C infection were risk factors of HBsAg positive. All above suggest the necessity and importance of the hepatitis B vaccination. Thus, the intervention of hepatitis B vaccination could reduce the risk of HBV infection among compulsory detoxification drug users.
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  • 收稿日期:  2016-02-05
  • 修回日期:  2016-06-20

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