A retrospective study of hepatic carcinoma in Guangxi Long'an County:from 2006 to 2014
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摘要: 目的 探讨广西隆安县原发性肝癌流行病学特征及危险因素。方法 回顾性调查隆安县2006-2014年发病的原发性肝癌患者共2 170例，通过查阅纸质报告表、病案、肿瘤直报系统等方法收集其基本人口学资料、诊断与报告情况、乙肝病毒和丙肝病毒感染以及免疫接种情况，并对上述资料进行统计分析。结果 病例以35岁以上中老年男性为主，平均年龄（57.22±14.61）岁，男女性别比为3.50：1，壮族占绝大多数。2 170名研究对象中，457例（21.06%）患者乙型肝炎病毒表面抗原（hepatitis B surface antigen，HBsAg）阳性，10例（0.46%）抗-丙肝病毒抗体（anti-hepatitis C virus IgG，anti-HCV IgG）阳性，3例HBsAg和抗-HCV IgG均为阳性。HBsAg感染率为65.76%（457/695），丙肝病毒（hepatitis C virus，HCV）感染率为1.79%（10/558）。除24例研究对象乙肝疫苗接种史不详以外，其余均无乙肝疫苗接种史。2006-2014年粗发病率为60.50/10万，中国人口标化发病率为32.11/10万，世界人口标化发病率为43.60/10万。2012-2014年发病率出现逐年上升趋势。结论 隆安县是肝癌高发区，且近年发病上升。乙肝病毒感染是隆安县肝癌发病主要危险因素之一。Abstract: Objective To investigate epidemiological characteristics and risk factors of primary hepatic carcinoma (PHC) in Guangxi Long'an County. Methods 2 170 PHC cases in Long'an County were retrospectively investigated by looking up to report forms on paper, medical record, and cancer direct report system. Information of basic demographic, diagnosis and report, infection of hepatitis B virus and hepatitis C virus, and status of immunization were collected and analyzed. Results Most of the study subjects were men over the age of 35. The mean age was 57.22±14.61 years. Male-female sex ratio was 3.50:1. Among the 2 170 study objects, 457 (21.06%) cases were HBsAg positive; 10 (0.46%) cases were anti-HCV IgG positive; 3 cases were both HBsAg and anti-HCV IgG positive. Most of the patients were Zhuang. Infection rates of HBV and HCV were 65.76% (457/695) and 1.79% (10/558) respectively. Except twenty four study subjects with unknown history of hepatitis B vaccination, there was no history of hepatitis B vaccination in other cases. Crude incidence rate during 2006-2014 was 60.50 per 100 000. Population of China standardized morbidity was 32.11 per 100 000. World population standardized morbidity was 43.60 per 100 000. Morbidity in 2012-2014 demonstrated a trend of rising year by year. Conclusions Long'an County is a PHC high incidence region and the incidence rate increased considerably in recent years. HBV infection is one of the major PHC risk factors in Long'an County.
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Key words:
- Liver neoplasms /
- Retrospective study /
- Morbidity /
- Risk factors
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Schinzari V, Barnaba V, Piconese S. Chronic Hepatitis B virus and Hepatitis C virus infections and cancer:synergy between viral and host factors [J]. Clin Microbiol Infect, 2015,21(11):969-974. 陈钦艳,董柏青,谭明杰,等. 隆安县乙型肝炎病毒感染的分子流行病学研究 [J]. 应用预防医学, 2007,13(3):142-145. 陆新蕾. 从筹备到实施:现代人口普查在中国(1936-1964) [D]. 上海:复旦大学, 2009. 郭志勇. 中国历史人口之数量分析 [J]. 华北水利水电学院学报(社科版), 2012,28(2):36-39. 陈琼,刘志才,程兰平,等. 2003-2007年中国结直肠癌发病与死亡分析 [J]. 中国肿瘤, 2012,(3):179-182. 陈万青,张思维,曾红梅,等. 中国2010年恶性肿瘤发病与死亡 [J]. 中国肿瘤, 2014,(1):1-10. 陈建国. 中国肝癌发病趋势和一级预防 [J]. 临床肝胆病杂志, 2012,28(4):256-260. Fitzmaurice C, Dicker D, Pain A, et al. The global burden of cancer 2013 [J]. JAMA Oncol, 2015,1(4):505-527. 韦忠亮,李云西,何明荣. 扶绥县2004-2008年肝癌发病率分析 [J]. 中国癌症防治杂志, 2011,3(2):137-138. 陈建国,朱健,张永辉,等. 肝癌流行趋势的改变:基于启东40年癌症登记资料的分析 [J]. 中国肿瘤, 2014,(8):621-628. Bergquist A, von Seth E. Epidemiology of cholangiocarcinoma [J]. Best Pract Res Clin Gastroenterol, 2015,29(2):221-232. Kar P. Risk factors for hepatocellular carcinoma in India [J]. J Clin Exp Hepatol, 2014,4(Suppl 3):S34-42. Waghray A, Murali AR, Menon KN. Hepatocellular carcinoma: From diagnosis to treatment [J]. World J Hepatol, 2015,7(8):1020-1029. Yang Y, Wu QJ, Xie L, et al. Prospective cohort studies of association between family history of liver cancer and risk of liver cancer [J]. Int J Cancer, 2014, 135(7):1605-1614. Yeh MM, Yeung RS, Apisarnthanarax S, et al. Multidisciplinary perspective of hepatocellular carcinoma: A Pacific Northwest experience [J]. World J Hepatol, 2015,7(11):1460-1483. Guidotti LG, Isogawa M, Chisari FV. Host-virus interactions in hepatitis B virus infection [J]. Curr Opin Immunol, 2015,36:61-66. Lamontagne J, Steel LF, Bouchard MJ. Hepatitis B virus and microRNAs:complex interactions affecting hepatitis B virus replication and hepatitis B virus-associated diseases [J]. World J Gastroenterol, 2015, 21(24):7375-7399. Goossens N, Hoshida Y. Hepatitis C virus-induced hepatocellular carcinoma [J]. Clin Mol Hepatol, 2015,21(2):105-114. 朱渭萍,王远萍,费怡,等. 上海市浦东新区不同人群乙肝病毒感染现状与免疫策略研究 [J]. 中华疾病控制杂志, 2014,18(2):112-116. 张艳彪,程锦泉,郝元涛,等. 深圳市流动人口与户籍居民乙肝感染情况比较分析 [J]. 中华疾病控制杂志, 2012,16(5):424-427. 付朝伟,王学才,王法弟,等. 浙江省德清县农村社区成人HBsAg阳性率调查 [J]. 复旦学报(医学版), 2008,35(4):556-559. 李杰,陈杰,庄辉. 丙型肝炎的流行病学 [J]. 实用肝脏病杂志, 2012,15(5):379-383. 张思维,郑荣寿,曾红梅,等. 1989-2008年中国肝癌发病性别、地区及年龄变化分析 [J]. 中华预防医学杂志, 2014,48(5):355-360. -
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