Abstract: Objective To evaluate the combined effects of hypertension and central obesity on the risk of cardio-cerebrovascular diseases. Methods A total of 9 984 residents from Suzhou New District were recruited as study subjects in our cross-sectional study from March 2016 to April 2016. Demographic data, disease and lifestyle history were collected. Physical and biochemical indicators were examined for all individuals. Logistic regression model was used to analyze the association between central obesity combined with hypertension and cardio-cerebrovascular diseases. Results Among 9 984 participants, 396 people suffered from cardio-cerebrovascular diseases (period prevalence:3.97%), including 243 coronary heart disease patients (period prevalence:2.43%), and 178 stroke patients (period prevalence:1.78%). Compared with normotensives with non-central obesity, in a multivariate adjusted model, the OR and 95% CI of stroke, coronary heart disease and cardio-cerebrovascular diseases for hypertensives with central obesity were 3.10(1.78-5.40), 2.56(1.61-4.07) and 3.06(2.10-4.45), respectively (all P<0.05). Conclusion These results indicate that the coexistence of hypertension and central obesity may increase the risk of cardio-cerebrovascular diseases.